Lung Cancer Clinical Trial
Study Evaluating MAC-321 in Non-small Cell Lung Cancer Refractory to Platinum-based Therapy
Summary
This non-randomized, open-label clinical trial is designed to determine safety and clinical activity of a new chemotherapeutic agent, MAC-321, when given intravenously to patients with non-small cell lung cancer. Clinical activity will be evaluated by determining the percentage of patients with an objective tumor response after treatment with MAC-321. Patients must have been previously treated with a platinum-containing chemotherapy regimen.
A total of 96 patients will be enrolled in this trial. Eligible patients will receive MAC-321 intravenously every 3 weeks for up to a total of 6 courses of treatment. All patients will receive MAC-321 at the same dose. MAC-321 is an experimental drug, and is not offered outside of this research trial.
Eligibility Criteria
Inclusion Criteria:
Recurrence of non-small cell lung cancer after at least 1 prior chemotherapy regimen containing a platinum agent
Recovery from all acute side effects of prior therapies (with the exception of hair loss)
Adequate bone marrow, liver, and kidney function
Exclusion Criteria:
More than 2 prior chemotherapy regimens for treatment of advanced or metastatic non-small cell lung cancer. (Treatment given in conjunction with surgery will not be included in the maximum of 2 prior regimens)
Radiation therapy, chemotherapy or any other anticancer therapy within 28 days of beginning study
Symptomatic brain metastases
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There are 13 Locations for this study
Los Angeles California, 90033, United States
Lexington Kentucky, 40536, United States
Baltimore Maryland, 21231, United States
Worcester Massachusetts, 01655, United States
Minneapolis Minnesota, 55455, United States
St. Louis Missouri, 63110, United States
New York New York, 10032, United States
Charlotte North Carolina, 28203, United States
Cleveland Ohio, 44195, United States
Philadelphia Pennsylvania, 19140, United States
Pittsburgh Pennsylvania, 15213, United States
Charleston South Carolina, 29425, United States
Nashville Tennessee, 37232, United States
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