Lung Cancer Clinical Trial

Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010]

Summary

This is a Phase III, global, multicenter, open-label, randomized study to compare the efficacy and safety of 16 cycles (1 cycle duration=21 days) of atezolizumab (MPDL3280A) treatment compared with best supportive care (BSC) in participants with Stage IB-Stage IIIA non-small cell lung cancer (NSCLC) following resection and adjuvant chemotherapy, as measured by disease-free survival (DFS) as assessed by the investigator and overall survival (OS). Participants, after completing up to 4 cycles of adjuvant cisplatin-based chemotherapy, will be randomized in a 1:1 ratio to receive atezolizumab for 16 cycles or BSC.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Inclusion Criteria for Enrollment Phase

Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
Histological or cytological diagnosis of Stage IB (tumors greater than or equal to [>/=] 4 centimeters [cm])-IIIA (T2-3 N0, T1-3 N1, T1-3 N2, T4 N0-1) NSCLC (per the Union Internationale Contre le Cancer staging system (UICC)/American Joint Committee on Cancer staging system (AJCC) staging system, 7th edition; Detterbeck et al. 2009)
Participants must have had complete resection of NSCLC 4-12 weeks (>/=28 days and less than or equal to [surgery
If mediastinoscopy was not performed preoperatively, it is required that, at a minimum, mediastinal lymph node systematic sampling will have occurred. Systematic sampling is defined as removal of at least one representative lymph node at specified levels. MLND entails resection of all lymph nodes at those same levels. For a right thoracotomy, sampling or MLND is required at levels 4 and 7 and for a left thoracotomy, levels 5 and/or 6 and 7. Exceptions will be granted if there is clear documentation in the operative report or in a separately submitted addendum by the surgeon of exploration of the required lymph node areas, the participant will be considered eligible if no lymph nodes are found in those areas; if participants have documented N2 disease in one level (per the UICC/AJCC staging system, 7th edition; Detterbeck et al. 2009), not all levels need to be sampled; if the preoperative staging imaging results (contrast computed tomography [CT] and positron emission tomography [PET] scans) do not suggest evidence of disease in the mediastinum, the participant will be considered eligible if N2 nodal sampling is not performed per surgeon's decision
Eligible to receive a cisplatin-based chemotherapy regimen
Adequate hematologic and end-organ function
Women who are not postmenopausal (>/=12 months of non-therapy-induced amenorrhea) or surgically sterile must have a negative serum pregnancy test result within 14 days prior to initiation of cisplatin-based chemotherapy

Inclusion Criteria for Randomized Phase - Women who are not postmenopausal (>/=12 months of non-therapy-induced amenorrhea) or surgically sterile must have a negative serum pregnancy test result within 14 days prior to initiation of atezolizumab or BSC

Exclusion Criteria:

Exclusion Criteria for Enrollment Phase

Illness or condition that may interfere with a participant's capacity to understand, follow, and/or comply with study procedures
Pregnant and lactating women
Treatment with prior systemic chemotherapy: Chemotherapy for early stage of malignancy with curative intent, provided that the last dose received was more than 5 years prior to enrollment and low-dose chemotherapy for non-malignant conditions may be allowed upon approval by the Medical Monitor
Hormonal cancer therapy or radiation therapy as prior cancer treatment within 5 years before enrollment
Treatment with any other investigational agent with therapeutic intent within 28 days prior to enrollment
Participants with hearing impairment
Known sensitivity to any component of the chemotherapy regimen the participant will be assigned to, or to mannitol
Prior treatment with cluster of differentiation (CD) 137 (CD137) agonists or immune checkpoint blockade therapies, anti-programmed death-1 (PD-1), and anti programmed death ligand 1 (PD-L1) therapeutic antibodies
Malignancies other than NSCLC within 5 years prior to randomization, with the exception of those with a negligible risk of metastasis or death (e.g., expected 5-year OS greater than [>] 90 percent [%]) treated with expected curative outcome (such as adequately treated carcinoma in situ of the cervix, basal or squamous cell skin cancer, localized prostate cancer treated surgically with curative intent, ductal carcinoma in situ treated surgically with curative intent)
History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins
Known hypersensitivity to biopharmaceuticals produced in Chinese hamster ovary cells or any component of the atezolizumab formulation
History of autoimmune disease, including but not limited to myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjögren's syndrome, Guillain-Barré syndrome, multiple sclerosis, vasculitis, or glomerulonephritis
Positive test for human immunodeficiency virus (HIV)
Participants with active hepatitis B (chronic or acute; defined as having a positive hepatitis B surface antigen [HBsAg] test at screening) or hepatitis C
Active tuberculosis
Significant cardiovascular disease, such as New York Heart Association cardiac disease (Class II or greater), myocardial infarction, or cerebrovascular accident within the previous 3 months, unstable arrhythmias, or unstable angina
History of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening chest CT scan
Prior allogeneic bone marrow transplantation or solid organ transplant
Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or render the participant at high risk from treatment complications
Known tumor PD-L1 expression status as determined by an immunohistochemistry (IHC) assay from other clinical studies (e.g., participants whose PD-L1 expression status was determined during screening for entry into a study with anti-PD-1 or anti-PD-L1 antibodies but were not eligible are excluded)

Specific Exclusions for Pemetrexed Treatment

- Participants with squamous cell histology

Exclusion Criteria for Randomized Phase

Signs or symptoms of infection within 14 days prior to randomization (severe infection within 28 days prior to randomization), including but not limited to hospitalization for complications of infection, bacteremia, or severe pneumonia
Received therapeutic oral or intravenous (IV) antibiotics within 14 days prior to randomization
Major surgical procedure within 28 days prior to randomization or anticipation of need for a major surgical procedure during the course of the study
Administration of a live, attenuated vaccine within 4 weeks prior to initiation of study treatment or anticipation that such a live attenuated vaccine will be required during the study
Treatment with systemic immunostimulatory agents (including but not limited to interferons or interleukin-2) within 4 weeks or 5 half-lives of the drug, whichever is longer, prior to randomization: Prior treatment with cancer vaccines is allowed
Treatment with systemic corticosteroids or other immunosuppressive medications (including but not limited to prednisone, dexamethasone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor [anti-TNF] agents) within 14 days prior to randomization

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

1280

Study ID:

NCT02486718

Recruitment Status:

Active, not recruiting

Sponsor:

Hoffmann-La Roche

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There are 224 Locations for this study

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Highlands Oncology Group
Springdale Arkansas, 72762, United States
Southern California Permanente Medical Group Bellflower
Bellflower California, 90706, United States
Compassionate Cancer Care Medical Group, Inc
Corona California, 92882, United States
Stanford University
Palo Alto California, 94305, United States
California Cancer Associates for Research & Excellence, Inc.
San Marcos California, 92069, United States
University of California Los Angeles
Santa Monica California, 90404, United States
Kaiser Permanente; Oncology Clinical Trials
Vallejo California, 94589, United States
Kaiser Permanente - Walnut Creek
Walnut Creek California, 94596, United States
Praxair Cancer Center at Danbury Hospital
Danbury Connecticut, 06810, United States
Eastern Connecticut Hematology and Oncology Associates; (ECHO)
Norwich Connecticut, 06360, United States
Lynn Cancer Institute - West
Boca Raton Florida, 33428, United States
University of Miami School of Medicine - Sylvester at Deerfield
Deerfield Beach Florida, Suite, United States
Holy Cross Hospital Inc
Fort Lauderdale Florida, 33308, United States
Florida Cancer Specialists-Broadway, Fort Myers
Fort Myers Florida, 33908, United States
SCRI Florida Cancer Specialists North; Research Office North Region.
Saint Petersburg Florida, 33705, United States
SCRI Florida Cancer Specialists East
West Palm Beach Florida, 33401, United States
University Cancer & Blood Center, LLC; Research
Athens Georgia, 30607, United States
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
Carrollton Georgia, 30117, United States
Lewis Hall Singletary Oncology Center
Thomasville Georgia, 31792, United States
Rush University Medical Center
Chicago Illinois, 60612, United States
University of Illinois at Chicago
Chicago Illinois, 60612, United States
Ingalls Memorial Hospital
Harvey Illinois, 60426, United States
Illinois Cancer Care
Peoria Illinois, 61615, United States
Quincy Medical Group; Canc Ctr at Blessing Hosp
Quincy Illinois, 62301, United States
Southern Illinois University, Simmons Cancer Institute
Springfield Illinois, 62794, United States
Norton Cancer Institute
Louisville Kentucky, 40202, United States
New England Cancer Specialists
Scarborough Maine, 04074, United States
Karmanos Cancer Institute
Detroit Michigan, 48201, United States
Cancer and Hematology Centers of Western Michigan
Grand Rapids Michigan, 49503, United States
Hematology and Oncology Associates at Bridgepoint
Tupelo Mississippi, 38801, United States
St. Luke's Cancer Institute
Kansas City Missouri, 64111, United States
Comprehensive Cancer Centers of Nevada
Henderson Nevada, 89014, United States
Hematology Oncology Associates of Northern New Jersey
Florham Park New Jersey, 07932, United States
Saint Barnabas Medical Center
Livingston New Jersey, 07039, United States
Valley Hospital; Oncology Research
Paramus New Jersey, 07652, United States
Overlook Medical Center; Medical Diagnostic Associates
Summit New Jersey, 07901, United States
Weill Cornell Medical College
New York New York, 10065, United States
Clinical Research Alliance
Westbury New York, 11590, United States
Presbyterian Hospital
Charlotte North Carolina, 28204, United States
University of Cincinnati
Cincinnati Ohio, 45203, United States
Oncology Hematology Care - SCRI
Cincinnati Ohio, 45242, United States
Mark H. Zangmeister Center
Columbus Ohio, 43219, United States
Oregon Health and Science University
Portland Oregon, 97239, United States
St. Luke's Cancer Care Associates
Bethlehem Pennsylvania, 18015, United States
Pinnacle Health
Harrisburg Pennsylvania, 17110, United States
Allegheny General Hospital
Pittsburgh Pennsylvania, 15212, United States
Rhode Island Hospital
Providence Rhode Island, 02903, United States
Greenville Health System
Greenville South Carolina, 29605, United States
University Oncology Associates
Chattanooga Tennessee, 37403, United States
SCRI Tennessee Oncology Chattanooga
Chattanooga Tennessee, 37404, United States
Sarah Cannon Cancer Center
Germantown Tennessee, 38138, United States
Houston Methodist Cancer Center
Houston Texas, 77030, United States
Wellmont Medical Associates
Bristol Virginia, 24201, United States
Hematology Oncology Associates of Fredericksburg, Inc.
Fredericksburg Virginia, 22408, United States
MultiCare Regional Cancer Center - Auburn
Auburn Washington, 98002, United States
Providence Everett Med Ctr
Everett Washington, 98201, United States
Swedish Medical Center
Seattle Washington, 98104, United States
Townsville Hospital
Townsville Queensland, 4810, Australia
Cabrini Hospital Malvern
Malvern Victoria, 3144, Australia
Cliniques Universitaires St-Luc
Bruxelles , 1200, Belgium
CHU Sart-Tilman
Liège , 4000, Belgium
William Osler Health Centre
Etobicoke Ontario, M9V 1, Canada
Cite de La Sante de Laval; Hemato-Oncologie
Laval Quebec, H7M 3, Canada
Cancer Institute and Hospital Chinese Academy of Medical Sciences
Beijing , 10002, China
Beijing Cancer Hospital
Beijing , 10014, China
Chinese People's Liberation Army (PLA) General Hospital (301 Hospital)
Beijing , 10085, China
Affiliated Hospital of Guangdong Medical University
Guangdong , 52402, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou , 51012, China
Anhui Province Cancer Hospital
Hefei City , 23003, China
Shanghai Chest Hospital
Shanghai , 20000, China
Shanghai Pulmonary Hospital
Shanghai , 20043, China
Liaoning Provincial Cancer Hospital
Shengyang , 11004, China
First Hospital of China Medical University
Shenyang , 11000, China
First Affiliated Hospital of Soochow University
Suzhou , 21500, China
Zhejiang Cancer Hospital
Zhejiang , 31002, China
Hôpital Universitaire Dupuytren
Limoges , 87042, France
Centre Léon Bérard Centre Régional de Lutte Contre Le Cancer Rhône Alpes
Lyon , 69008, France
Hôpital Saint Joseph; Oncologie Medicale
Marseille , 13285, France
Centre Hospitalier de Mont de Marsan - Hopital Layne
Mont De Marsan , 40024, France
Clinique Clémentville
Montpellier , 34070, France
Centre Regional de Lutte contre le Cancer Val d Aurelle - Paul Lamarque; Service d oncologie
Montpellier , 34298, France
Centre René Gauducheau Centre de Lutte Contre Le Cancer Nantes Atlantique
Nantes , 44805, France
Centre Hospitalier Regional Sud Reunion; Service de Pneumologie
Saint Pierre , 97448, France
Hopital d'Instruction des Armees de Begin
Saint-Mande , 94160, France
Centre Hospitalier de Saint-Quentin; Pharmacie-URCC
Saint-Quentin , 02321, France
Centre Hospitalier Intercommunal Toulon - La Seyne sur Mer
Toulon , 83000, France
Hopital d Instruction des Armees de Sainte Anne
Toulon , 83041, France
Evang. Lungenklinik Berlin Klinik für Pneumologie
Berlin , 13125, Germany
Ev.Krankenhaus Bielefeld gGmbH; Klinik für Innere Medizin und Geriatrie
Bielefeld , 33611, Germany
Stadtisches Klinikum Braunschweig
Braunschweig , 38114, Germany
Klinikum Chemnitz gGmbH
Chemnitz , 09116, Germany
Krankenhaus Nordwest
Frankfurt am Main , 60488, Germany
LungenClinic Großhansdorf GmbH
Großhansdorf , 22927, Germany
Krankenhaus Martha-Maria; Halle-Dolau gGmbH
Halle , 06120, Germany
Universitätsklinikum Hamburg-Eppendorf
Hamburg , 20246, Germany
Asklepios Klinik Harburg
Hamburg , 21075, Germany
Thoraxklinik Heidelberg gGmbH
Heidelberg , 69126, Germany
Lungenklinik Hemer
Hemer , 58675, Germany
Universität Des Saarlandes
Homburg , 66421, Germany
Fachklinik für Lungenerkrankungen
Immenhausen , 34376, Germany
Vincentius-Diakonissen-Kliniken gAG
Karlsruhe , 76137, Germany
Katholisches Klinikum Marienhof
Koblenz Am Rhein , 56073, Germany
Kliniken der Stadt Koln gGmbH; Lungenklinik Onkologische Ambulanz
Koln , 51109, Germany
SLK Kliniken Heilbronn GmbH, Standort Fachklinik Löwenstein; Onk & Pal
Löwenstein , 74245, Germany
Klinikum Bogenhausen
München , 81925, Germany
Gemeinschaftspraxis für Hämatologie und Onkologie
Münster , 48153, Germany
Pius-Hospital Oldenburg
Oldenburg , 26121, Germany
Krankenhaus Barmherzige Bruder Regensburg
Regensburg , 93049, Germany
Praxis fur Hamatologie und internistische Onkologie
Velbert , 42551, Germany
Prince of Wales Hosp; Dept. Of Clinical Onc
Shatin , , Hong Kong
Semmelweis Egyetem
Budapest , 1083, Hungary
University of Pecs, I st Dept of Internal Medicine
Pecs , 7624, Hungary
Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rend.Int.
Szolnok , 5000, Hungary
Tudogyogyintezet Torokbalint
Torokbalint , 2045, Hungary
Rambam Medical Center; Oncology
Haifa , 31096, Israel
Edith Wolfson Medical Center
Holon , 58220, Israel
Meir Medical Center; Oncology
Kfar-Saba , 44281, Israel
Rabin Medical Center
Petach Tikva , 49222, Israel
Chaim Sheba Medical Center; Oncology Dept
Ramat Gan , 52621, Israel
Tel Aviv Sourasky Medical Ctr; Oncology
Tel Aviv , 64239, Israel
Ospedale Clinicizzato SS Annunziata
Chieti Abruzzo, 66100, Italy
Azienda per l'Assistenza Sanitaria N° 5 - Friuli Occidentale; S.C. Oncologia Pordenone
Pordenone Friuli-Venezia Giulia, 33170, Italy
Policlinico Universitario Campus Biomedico Di Roma; U.O.Oncologia Medica
Roma Lazio, 00128, Italy
Asst Papa Giovanni XXIII; Oncologia Medica
Bergamo Lombardia, 24127, Italy
ASST Spedali Civili di Brescia
Brescia Lombardia, 25123, Italy
Ospedale San Raffaele
Milano Lombardia, 20132, Italy
Azienda Sanitaria Ospedaliera s. Croce e Carle; Oncologia Medica
Cuneo Piemonte, 12100, Italy
A.O.U. Maggiore della Carità
Novara Piemonte, 28100, Italy
Azienda Sanitaria Ospedaliera S Luigi Gonzaga
Orbassano Piemonte, 10043, Italy
Azienda Ospedaliera Città della Salute e della Scienza di Torino
Torino Piemonte, 10126, Italy
Azienda Ospedaliera Di Rilievo Nazionale E Di Alta Specializzazione Garibaldi
Palermo Sicilia, 90127, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa Toscana, 56100, Italy
Ospedale Santa Chiara; Oncologia Medica
Trento Trentino-Alto Adige, 38100, Italy
Ospedale Silvestrini
Perugia Umbria, 06122, Italy
Azienda Ospedaliera Universitaria Integrata Verona; UOC Oncologia
Verona Veneto, 37126, Italy
Aichi Cancer Center Hospital
Aichi , 464-8, Japan
Nagoya University Hospital
Aichi , 466-8, Japan
National Cancer Center East
Chiba , 277-8, Japan
Shikoku Cancer Center
Ehime , 791-0, Japan
Kyushu University Hospital
Fukuoka , 812-8, Japan
Hiroshima University Hospital
Hiroshima , 734-8, Japan
National Hospital Organization Hokkaido Cancer Center
Hokkaido , 003-0, Japan
Hyogo Cancer Center
Hyogo , 673-0, Japan
Kanagawa Cancer Center
Kanagawa , 241-8, Japan
Hospital of the University of Occupational and Environmental Health,Japan
Kitakyushu-shi , 807-8, Japan
Kumamoto University Hospital
Kumamoto , 860-8, Japan
Kyoto University Hospital
Kyoto , 606-8, Japan
Sendai Kousei Hospital
Miyagi , 980-0, Japan
Niigata Cancer Center Hospital
Niigata , 951-8, Japan
Okayama University Hospital
Okayama , 700-8, Japan
Saitama Cancer Center
Saitama , 362-0, Japan
Shizuoka Cancer Center
Shizuoka , 411-8, Japan
National Cancer Center Hospital
Tokyo , 104-0, Japan
Toranomon Hospital
Tokyo , 105-8, Japan
Juntendo University Hospital
Tokyo , 113-8, Japan
Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital
Tokyo , 113-8, Japan
Tokyo Medical University Hospital
Tokyo , 160-0, Japan
Kyorin University Hospital
Tokyo , 181-8, Japan
Wakayama Medical University Hospital
Wakayama , 641-8, Japan
Chonnam National University Hwasun Hospital
Jeollanam-do , 58128, Korea, Republic of
The Catholic University of Korea St. Vincent's Hospital
Suwon-si, , 442-7, Korea, Republic of
Jeroen Bosch Ziekenhuis
'S Hertogenbosch , 5223 , Netherlands
Martini Ziekenhuis
Groningen , 9728 , Netherlands
St. Antonius Ziekenhuis Nieuwegein
Nieuwegein , 3435 , Netherlands
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy
Otwock , 05-40, Poland
Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu
Poznan , 60-56, Poland
Centro Hospitalar E Universitário de Coimbra EPE
Coimbra , 3000-, Portugal
Centro Hospitalar de Lisboa Norte E.P.E - Hospital Pulido Valente
Lisboa , 1769-, Portugal
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe
Porto , 4200-, Portugal
Hospital de Sao Joao; Servico de Pneumologia
Porto , 4200, Portugal
Oncology Center Sf. Nectarie
Craiova , 20034, Romania
Moscow City Oncology Hospital #62
Moscovskaya Oblast Moskovskaja Oblast, 14342, Russian Federation
Principal Military Clinical Hospital n.a. N.N. Burdenko
Moscow Moskovskaja Oblast, 10522, Russian Federation
Russian Oncology Research Center n a N N Blokhin
Moscow Moskovskaja Oblast, 11547, Russian Federation
Scientific Research Institute of Oncology n.a. N.N. Petrov; Department of Oncogynecology
St. Petersburg Sankt Petersburg, 19775, Russian Federation
Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic
Kazan Tatarstan, 42002, Russian Federation
City Clinical Hospital #1; Dpt of Oncology
Novosibirsk , 63004, Russian Federation
Evromedservis LCC
Pushkin , 19660, Russian Federation
GBUZ Saint Petersburg Clinical Research Center of Specialized Types of Care (Oncology)
Saint Petersburg , 19775, Russian Federation
City Clinical Oncology Dispensary
Saint-Petersburg , 19702, Russian Federation
Mordovia State University
Saransk , 43003, Russian Federation
Leningrad Regional Clinical Hospital
St Petersburg , 19429, Russian Federation
St. Petersburg Med Univ; n.a. I.P. Pavlov; Pulmonology Research
St Petersburg , 19708, Russian Federation
Volgograd Regional Clinical Oncology Dispensary
Volgograd , 40013, Russian Federation
Regional Clinical Oncology Hospital
Yaroslavl , 15004, Russian Federation
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
Badalona Barcelona, 08916, Spain
Hospital Universitario Marques de Valdecilla; Servicio de Oncologia
Santander Cantabria, 39008, Spain
Consorcio Hospitalario Provincial de Castellon
Castellon DE LA Plana/castello DE LA Plana Castellon, 12002, Spain
Hospital Universitario Son Espases
Palma De Mallorca Islas Baleares, 07014, Spain
Centro Oncologico de Galicia COG; Medical Oncology
A Coruna LA Coruña, 15009, Spain
Hospital Universitario Virgen de La Arrixaca; Servicio De Oncologia
El Palmar Murcia, 30120, Spain
Hospital Universitario de Canarias
S. Cristobal De La Laguna Tenerife, 38320, Spain
Hospital del Mar
Barcelona , 08003, Spain
Hospital Univ Vall d'Hebron; Servicio de Oncologia
Barcelona , 08035, Spain
Hospital Santa Creu i Sant Pau
Barcelona , 08041, Spain
C.H. Regional Reina Sofia
Cordoba , 14004, Spain
Complejo Hospitalario de Jaen
Jaen , 23007, Spain
Hospital Lucus Augusti; Servicio de Oncologia
Lugo , 27003, Spain
Hospital Universitario La Paz
Madrid , 28014, Spain
Hospital Ramon y Cajal; Servicio de Oncologia
Madrid , 28034, Spain
Hosp. Clinico San Carlos
Madrid , 28040, Spain
Hospital Universitario HM Sanchinarro-CIOCC; Oncología Médica
Madrid , 28050, Spain
Hospital Clinico Universitario de Valencia
Valencia , 46010, Spain
Hospital NisA 9 de Octubre
Valencia , 46015, Spain
Hospital Universitari i Politecnic La Fe de Valencia
Valencia , 46026, Spain
Hosp Clinico Univ Lozano Blesa
Zaragoza , 50009, Spain
Changhua Christian Hospital
Chang Hua , 500, Taiwan
Kaohsiung Medical University Hospital; Department of Urology
Kaohsiung City , 807, Taiwan
Chi Mei Medical Center Liou Ying Campus
Liuying Township , 736, Taiwan
Chang Gung Memorial Hospital Chiayi
Putzu , 613, Taiwan
National Taiwan Uni Hospital
Taipei City , 10041, Taiwan
Taipei Veterans General Hospital
Taipei City , 112, Taiwan
Mackay Memorial Hospital
Taipei , 104, Taiwan
Chang Gung Medical Foundation Linkou Branch
Taoyuan City , 333, Taiwan
Taichung Veterans General Hospital
Xitun Dist. , 40705, Taiwan
MI Dnipropetrovsk City Multifield Clinical Hospital 4 of Dnipropetrovsk Regional Council
Dnipropetrovsk Katerynoslav Governorate, 49102, Ukraine
Communal Non profit Enterprise Regional Center of Oncology; Oncosurgical dept of thoracic organs
Kharkiv Kharkiv Governorate, 61070, Ukraine
Kyiv Railway Clinical Hospital #3 of Branch Health Center of the PJSC Ukrainian Railway
Kyiv KIEV Governorate, 02096, Ukraine
Municipal Institution Odesa Regional Oncology Dispensary
Odesa KIEV Governorate, 65055, Ukraine
Municipal Institution Podilskiy Regional Center of Oncology; Department of Chemotherapy
Vinnytsia Podolia Governorate, 21029, Ukraine
Municipal Institution SubCarpathian ClinicalOncological Centre; Chemotherapy department
Ivano-Frankivsk Poltava Governorate, 76018, Ukraine
Private Enterprise Private Manufacturing Company Acinus
Kirovograd , 25006, Ukraine
ME Kryviy Rih Oncology Dispensary of Dnipropetrovs'k Regional Council; Chemotherapy Department
Kryvyi Rih , 50048, Ukraine
Kyiv City Clinical Oncological Center
Kyiv , 03115, Ukraine
Regional Municipal Institution Sumy Regional Clinical Oncology Dispensary
Sumy , 40005, Ukraine
MI Zaporizhzhia Regional Clinical Oncological Dispensary Zaporizhzhia SMU Ch of Oncology
Zaporizhzhya , 69040, Ukraine
Birmingham Heartlands Hospital
Birmingham , B9 5S, United Kingdom
Colchester General Hospital
Colchester, Essex , CO4 5, United Kingdom
St Bartholomew's Hospital
London , EC1M , United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

1280

Study ID:

NCT02486718

Recruitment Status:

Active, not recruiting

Sponsor:


Hoffmann-La Roche

How clear is this clinincal trial information?

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