Study to Evaluate Safety, Efficacy, Pharmacokinetics And Pharmacodynamics Of Avelumab In Combination With Either Crizotinib Or PF-06463922 In Patients With NSCLC. (Javelin Lung 101)

Inclusion Criteria
Diagnosis of advanced or metastatic NSCLC. Group A must be ALK negative NSCLC and Group B must be ALK positive NSCLC
Group A at least one prior regimen of therapy
Group B any number of prior regimens.
Mandatory tumor tissue available
At least one measurable lesion
ECOG Performance status 0 or 1
Adequate bone marrow, renal, liver and pancreatic function
Negative pregnancy test for females of childbearing potential
Group B Phase 2: No prior systemic treatment for advanced or metastatic disease (adjuvant and/or neoadjuvant therapies are allowed if completed at least 6 months prior to study entry. No prior tyrosine kinase inhibitor therapy is allowed at any time prior to study entry)

Exclusion Criteria:

No prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or anti-CTLA-4 antibody.
No Severe or Chronic medical conditions including gastrointestinal abnormalities or significant cardiac history
No active infection requiring systemic therapy
Prior organ transplantation including allogenic stem cell transplantation.