Lung Cancer Clinical Trial
Tempus Sculptor Study: Small Cell Lung Cancer (SCLC) Observational Study
The study is a non-interventional evaluation of participants with SCLC who will receive diagnostic and (where possible) post-progression tumor tissue profiling, alongside plasma ctDNA biomarker profiling in addition to their standard of care therapy and disease surveillance.
Histologically confirmed small cell lung cancer diagnosis
Diagnosis made with excisional or core needle biopsy specimen (not aspirate)
ECOG performance status of 0 or 1 at time of enrollment
Planned extensive stage first-line therapy of etoposide plus carboplatin plus PD-L1 inhibitor (atezolizumab or durvalumab)
Extensive stage disease at time of diagnosis
Willing and able to provide informed consent
History of radiotherapy to the chest or planned consolidation chest radiotherapy
Prior diagnosis of non-small cell lung cancer
Mixed small cell and non-small cell histology
Suspected metastatic cancer from other sites (i.e., those without a known or suspected lung primary diagnosis)
Not willing to have additional blood samples collected
Ineligible for biopsy of lung primary or non-liver/bile metastatic site
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