The ATTAIN Study: A Therapeutic Trial of Afatinib In the Neoadjuvant Setting

Inclusion Criteria:

Histologically confirmed NSCLC, who are deemed to be surgical candidates by standard criteria. Patients with all types of NSCLC (e.g., adenocarcinoma, squamous cell carcinoma) will be allowed to enroll.
Patients with Stage IA to IIB disease. Select patients with resectable stage IIIA disease (T3N1, T4N0, T4N1) will also be eligible if approved by the PI.
Eastern Cooperative Oncology Group (ECOG) Performance Status 0-1
Measurable disease by RECIST 1.1 criteria
Mediastinoscopy and/or Endoscopic Bronchial Ultrasound (EBUS) and/or Endoscopic Ultrasound (EUS) for complete surgical staging when clinically indicated
Serious, active infections must be controlled. Patients may be enrolled while still on antibiotics as long as clinical signs of active infection have resolved.
A signed informed consent document (ICD)
Patients 18 years or older
Able and willing to take oral medications

Exclusion Criteria:

Known preexisting interstitial lung disease, interstitial pulmonary fibrosis, or connective tissue disorder associated lung disease
Known N2 nodal disease or distant metastatic disease
History or presence of clinically relevant cardiovascular abnormalities such as uncontrolled hypertension, congestive heart failure NYHA classification of 3, unstable angina or poorly controlled arrhythmia. Myocardial infarction within 6 months prior to randomization.
Patients with any of the following lab values at screening should be excluded: Absolute neutrophil count (ANC) < 1500 / mm^3; Platelet count < 100,000 / mm^3; Serum creatinine >/= 1.5 times the upper normal limit or calculated/measured creatinine clearance /=1.5mg/dL (> 26 mol/L, SI unit equivalent); Aspartate amino transferase (AST) or Alanine amino transferase (ALT) >/= three (3) times the upper limit of normal.
Active hepatitis B infection, active hepatitis C infection or known HIV carrier.
Known or suspected active drug or alcohol abuse
Significant or recent acute gastrointestinal disorders with diarrhea as a major symptom for example Crohn's disease, malabsorption or CTC grade >/= 2 diarrhea of any etiology.
Baseline (< 1 month before treatment) cardiac left ventricular function with resting ejection fraction of less than 50% measured by multigated blood pool imaging of the heart (MUGA scan) or echocardiogram
Patients receiving other investigational agent.
History of allergic reactions to anilinoquinazolins like gefitinib, erlotinib, or BIBW2992
Uncontrolled intercurrent illness that would preclude a patient from undergoing surgery
Psychiatric illness/social situations that would limit compliance with study requirements
Pregnant (positive pregnancy test) or lactating
Inability to comply with study and/or follow-up procedures
Patients who are not surgical candidates or refuse surgery