Vaccine Therapy and GM-CSF in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndromes, Non-Small Cell Lung Cancer, or Mesothelioma

DISEASE CHARACTERISTICS:

Cytologically or histologically confirmed diagnosis of 1 of the following:

Acute myeloid leukemia, meeting the following criteria:

Documented Wilms tumor-1 (WT-1)-positive disease demonstrated by WT-1 protein on a pretreatment bone marrow biopsy OR detectable disease with real-time quantitative reverse transcriptase-polymerase chain reaction (RQ-PCR)
Completed induction chemotherapy, achieved clinical remission, and completed postremission therapy OR achieved clinical remission and have no plans for further postremission chemotherapy (≥ 65 years of age)

Myelodysplastic syndromes, meeting the following criteria:

Documented WT-1-positive disease demonstrated by WT-1 protein on a pretreatment bone marrow biopsy OR detectable disease by RQ-PCR
International Prognostic Scoring System (IPSS) score of ≥ Int-2
Not a candidate for cytotoxic chemotherapy

Non-small cell lung cancer, meeting the following criteria:

Positive tumor staining for WT-1 in > 10% of cells
Stage III or IV disease
Completed chemotherapy, surgery, and/or radiotherapy

Mesothelioma, meeting the following criteria:

Positive tumor staining for WT-1 in > 10% of cells
Unresectable or relapsed disease
Chemo-naive or received 1 prior chemotherapy regimen
Malignant pleural mesothelioma or peritoneal mesothelioma
No leptomeningeal disease
No CNS involvement

PATIENT CHARACTERISTICS:

Karnofsky performance status 70-100%
Absolute neutrophil count ≥ 1,000/mm³
Platelet count > 50,000/mm³ (except for myelodysplastic syndromes where parameter is > 20,000/mm³ and not transfusion dependent)
Bilirubin ≤ 2.0 mg/dL
AST and ALT ≤ 2.5 times upper limit of normal
Creatinine ≤ 2.0 mg/dL
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception
No active infection requiring systemic antibiotics, antiviral, or antifungal treatments
No serious unstable medical illness

PRIOR CONCURRENT THERAPY:

See Disease Characteristics
At least 4 weeks since prior chemotherapy or radiotherapy
No concurrent systemic corticosteroids