Lung Cancer Clinical Trial

Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Treating Patients With Limited Stage or Extensive Stage Small Cell Lung Cancer

Summary

This randomized phase II/III trial studies how well whole-brain radiation therapy works and compares it with or without hippocampal avoidance in treating patients with small cell lung cancer that is found in one lung, the tissues between the lungs, and nearby lymph nodes only (limited stage) or has spread outside of the lung in which it began or to other parts of the body (extensive stage). Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. The hippocampus is part of the brain that is important for memory. Avoiding the hippocampus during whole-brain radiation could decrease the chance of side effects on memory and thinking. It is not yet known whether giving whole-brain radiation therapy is more effective with or without hippocampal avoidance in treating patients with small cell lung cancer.

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Full Description

PRIMARY OBJECTIVES:

I. Determine whether the 12-month intracranial relapse rate following hippocampal avoidance (HA)-prophylactic cranial irradiation (PCI) is non-inferior compared to the rate following PCI for patients with small cell lung cancer (SCLC). (Randomized Phase II Component [Non-Inferiority]) II. Determine whether HA-PCI reduces the likelihood of 6-month deterioration from baseline in Hopkins Verbal Learning Test (HVLT)-Revised (R) delayed recall compared to PCI for patients with SCLC. (Phase III Component [Efficacy])

SECONDARY OBJECTIVES:

I. Compare time to cognitive failure, as measured by a battery of tests (HVLT-R, Controlled Oral Word Association [COWA] test, and Trail Making Test [TMT] parts A and B), after PCI versus HA-PCI in SCLC.

II. Compare time to cognitive failure as separately measured by each test (HVLT-R for Total Recall and Delayed Recognition, COWA test, and TMT parts A and B), after PCI versus HA-PCI for SCLC.

III. Compare patient-reported cognitive functioning and other quality of life domains (assessed by the European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire [QLQ]-Core [C]30 and BN20) between PCI versus HA-PCI for patients with SCLC.

IV. Compare overall survival after PCI versus HA-PCI for patients with SCLC. V. Compare 12-month intracranial relapse rate (at completion of phase III) and time to intracranial relapse after PCI versus HA-PCI for patients with SCLC.

VI. Evaluate adverse events according to Common Terminology Criteria for Adverse Events (CTCAE) criteria.

VII. Correlate changes in health-related quality of life (HRQOL) domains with changes in cognitive testing outcomes following PCI versus HA-PCI for patients with SCLC.

VIII. Assess cost-effectiveness of HA-PCI (intensity modulated radiation therapy [IMRT]) and PCI (3-dimensional conformal radiation therapy [3DCRT]) using the EuroQual (EQ)-5-Dimensions (5D)-5L.

IX. Correlate miRNA signatures with cognitive failure in SCLC patients who received PCI and HA-PCI.

X. Evaluate APOE genotyping as potential predictor of neurocognitive decline, hippocampal atrophy after brain irradiation and/or differential benefit from hippocampal avoidance.

XI. Evaluate baseline MR imaging biomarkers of white matter injury and hippocampal volumetry as potential predictors of cognitive decline and differential benefit from HA-PCI as compared to PCI.

TERTIARY OBJECTIVES:

I. Collect serum, whole blood, and urine for future translational research analyses.

II. Evaluate baseline magnetic resonance (MR) imaging biomarkers of white matter injury and hippocampal volumetry as potential predictors of cognitive decline and differential benefit from HAPCI as compared to PCI.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients undergo PCI using 3DCRT daily for 2 weeks.

ARM II: Patients undergo PCI with HA using IMRT daily for 2 weeks.

After completion of study treatment, patients are followed every 3 months for 1 year, then every 6 months until 3 years and then annually until death.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

PRIOR TO STEP 1 REGISTRATION

Histologic proof or unequivocal cytologic proof (fine needle aspiration, biopsy or two positive sputa) of SCLC within 250 days prior to Step 1 registration

High-grade neuroendocrine carcinoma or combined SCLC and NSCLC is permitted.

Patients must have received chemotherapy and be registered to Step 1 registration no earlier than 7 days and no later than 56 days after completing chemotherapy. Note:

Post-chemotherapy restaging imaging must be completed no more than 56 days prior to Step 1 registration.
For patients with extensive-stage small cell lung cancer who are being considered for consolidative thoracic radiotherapy after chemotherapy, concomitant administration of consolidative thoracic radiotherapy and protocol-specified prophylactic cranial irradiation with or without hippocampal avoidance is permitted.

Patients must have a gadolinium contrast-enhanced three-dimensional (3D), spoiled gradient (SPGR), magnetization-prepared rapid gradient echo (MP-RAGE), or turbo field echo (TFE) MRI scan (see section 11.3 regarding axial T2/FLAIR sequence). To yield acceptable image quality, the gadolinium contrast-enhanced three-dimensional SPGR, MP-RAGE or TFE axial MRI scan must use the smallest possible axial slice thickness not exceeding 1.5 mm. Sites may contact the Imaging Co-Chairs for further information or assistance if needed.

This MRI must be obtained within 56 days prior to Step 1 registration. Note: The MRI study is mandatory irrespective of randomization to the experimental or control arm of this study.

Prior to chemotherapy +/- thoracic radiotherapy, patients must be defined as limited-stage or extensive-stage SCLC after clinical staging evaluation involving the following:

History/physical examination;
CT of the chest and abdomen with contrast (does not have to be done if the patient has had a PET/CT scan prior to initiating chemotherapy or thoracic radiotherapy);
MRI of the brain with contrast or diagnostic head CT with contrast;
For patients without evidence of extensive-stage SCLC on chest and abdomen CT and brain MRI or head CT, a PET/CT or bone scan is required to confirm limited-stage SCLC.

After chemotherapy, patients must be restaged prior to Step 1 registration using the same diagnostic work-up as required pre-chemotherapy. Repeat PET/CT or bone scan is not required. Patients must have:

History/physical examination within 30 days of Step 1 registration;
No CNS metastases (Repeat MRI required; see Section 3.2.3 for details) within 56 days prior to Step 1 registration;
No progression in any site;

Radiographic partial or complete response to chemotherapy in at least one disease site within 56 days prior to Step 1 registration.

If PET/CT was obtained prior to chemotherapy, either a repeat PET/CT or CT of the chest and abdomen with contrast can be obtained for response assessment.
Patients who underwent resection for limited-stage SCLC prior to chemotherapy and have no radiographically evident disease for response assessment remain eligible if post-chemotherapy imaging demonstrates no progression.
Zubrod performance status 0-2
Women of childbearing potential and male participants must practice adequate contraception
Women of childbearing potential must have a negative qualitative serum pregnancy test =< 2 weeks prior to study entry
Patients who are primary English or French speakers are eligible
Patients must sign a study-specific informed consent prior to study entry
PRIOR TO STEP 2 REGISTRATION
The following baseline neurocognitive assessments must be completed and uploaded within 10 calendar days after or at the time of Step 1 registration: HVLT-R (recall, delayed recall, and recognition), TMT (Parts A and B), and COWA. The neurocognitive assessments will be uploaded into the NRG Oncology RAVE System for evaluation by Dr. Wefel. Once the upload is complete, within 3 business days, a notification email will be sent to the site to proceed to Step 2 registration. At minimum, the HVLT-R delayed recall must be able to be scored (i.e. completed without error) in order to be eligible.
Patients must have a baseline raw score greater than 2 on the HVLT-R delayed recall

Exclusion Criteria:

Prior radiotherapy to the head or neck (except for T1 glottic cancer), resulting in overlap of radiation fields
Radiographic evidence of CNS metastases
Radiographic evidence of hydrocephalus or other architectural distortion of the ventricular system, including placement of external ventricular drain or ventriculoperitoneal shunt

Planned concurrent chemotherapy or anti-tumor agent during PCI

Concurrent atezolizumab permitted
Concomitant invasive malignancy or invasive malignancy within the past five years other than non-melanomatous skin cancer; history of in situ carcinoma (e.g. ductal carcinoma in situ of breast, in situ carcinoma of the cervix, vulva or larynx) is permitted
Contraindication to MR imaging, such as implanted metal devices or foreign bodies or severe claustrophobia

Severe, active comorbidity, defined as follows:

Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
Transmural myocardial infarction within the last 6 months
Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
Uncontrolled, clinically significant cardiac arrhythmias

HIV positive with CD4 count < 200 cells/microliter;

Note: Patients who are HIV positive are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count ≥ 200 cells/microliter within 30 days prior to Step 1 registration.
Note: HIV testing is not required for eligibility for this protocol.
Pregnant or lactating women or women of childbearing potential and male participants who are sexually active and not willing/able to use medically acceptable forms of contraception

Study is for people with:

Lung Cancer

Phase:

Phase 2

Estimated Enrollment:

418

Study ID:

NCT02635009

Recruitment Status:

Active, not recruiting

Sponsor:

NRG Oncology

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There are 272 Locations for this study

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University of Alabama at Birmingham Cancer Center
Birmingham Alabama, 35233, United States
Lewis and Faye Manderson Cancer Center
Tuscaloosa Alabama, 35401, United States
Banner University Medical Center - Tucson
Tucson Arizona, 85719, United States
Marin General Hospital
Greenbrae California, 94904, United States
Los Angeles County-USC Medical Center
Los Angeles California, 90033, United States
USC / Norris Comprehensive Cancer Center
Los Angeles California, 90033, United States
Mercy UC Davis Cancer Center
Merced California, 95340, United States
Kaiser Permanente Oakland-Broadway
Oakland California, 94611, United States
Saint Joseph Hospital - Orange
Orange California, 92868, United States
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova California, 95670, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville California, 95661, United States
The Permanente Medical Group-Roseville Radiation Oncology
Roseville California, 95678, United States
Sutter Medical Center Sacramento
Sacramento California, 95816, United States
University of California Davis Comprehensive Cancer Center
Sacramento California, 95817, United States
California Pacific Medical Center-Pacific Campus
San Francisco California, 94115, United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara California, 95051, United States
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee California, 96161, United States
Sutter Solano Medical Center/Cancer Center
Vallejo California, 94589, United States
Swedish Medical Center
Englewood Colorado, 80113, United States
Poudre Valley Hospital
Fort Collins Colorado, 80524, United States
Hartford HealthCare - Saint Vincent's Medical Center
Bridgeport Connecticut, 06606, United States
Yale University
New Haven Connecticut, 06520, United States
Helen F Graham Cancer Center
Newark Delaware, 19713, United States
Christiana Care Health System-Christiana Hospital
Newark Delaware, 19718, United States
Boca Raton Regional Hospital
Boca Raton Florida, 33486, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables Florida, 33146, United States
Broward Health Medical Center
Fort Lauderdale Florida, 33316, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami Florida, 33136, United States
Miami Cancer Institute
Miami Florida, 33176, United States
Orlando Health Cancer Institute
Orlando Florida, 32806, United States
Moffitt Cancer Center
Tampa Florida, 33612, United States
Grady Health System
Atlanta Georgia, 30303, United States
Emory University Hospital Midtown
Atlanta Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute
Atlanta Georgia, 30322, United States
Northside Hospital
Atlanta Georgia, 30342, United States
Northside Hospital-Forsyth
Cumming Georgia, 30041, United States
Memorial Health University Medical Center
Savannah Georgia, 31404, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah Georgia, 31405, United States
The Cancer Center of Hawaii-Pali Momi
'Aiea Hawaii, 96701, United States
Queen's Medical Center
Honolulu Hawaii, 96813, United States
The Cancer Center of Hawaii-Liliha
Honolulu Hawaii, 96817, United States
Saint Alphonsus Cancer Care Center-Boise
Boise Idaho, 83706, United States
Saint Luke's Cancer Institute - Boise
Boise Idaho, 83712, United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell Idaho, 83605, United States
Saint Luke's Cancer Institute - Meridian
Meridian Idaho, 83642, United States
Saint Alphonsus Medical Center-Nampa
Nampa Idaho, 83686, United States
Saint Luke's Cancer Institute - Nampa
Nampa Idaho, 83686, United States
Saint Luke's Cancer Institute - Twin Falls
Twin Falls Idaho, 83301, United States
Northwestern University
Chicago Illinois, 60611, United States
John H Stroger Jr Hospital of Cook County
Chicago Illinois, 60612, United States
Rush University Medical Center
Chicago Illinois, 60612, United States
Decatur Memorial Hospital
Decatur Illinois, 62526, United States
Crossroads Cancer Center
Effingham Illinois, 62401, United States
Northwestern Medicine Cancer Center Delnor
Geneva Illinois, 60134, United States
Edward Hines Jr VA Hospital
Hines Illinois, 60141, United States
Condell Memorial Hospital
Libertyville Illinois, 60048, United States
Loyola University Medical Center
Maywood Illinois, 60153, United States
Illinois CancerCare-Peoria
Peoria Illinois, 61615, United States
Methodist Medical Center of Illinois
Peoria Illinois, 61636, United States
OSF Saint Francis Medical Center
Peoria Illinois, 61637, United States
Memorial Medical Center
Springfield Illinois, 62781, United States
Carle Cancer Center
Urbana Illinois, 61801, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville Illinois, 60555, United States
Saint Vincent Anderson Regional Hospital/Cancer Center
Anderson Indiana, 46016, United States
Parkview Hospital Randallia
Fort Wayne Indiana, 46805, United States
Parkview Regional Medical Center
Fort Wayne Indiana, 46845, United States
Goshen Center for Cancer Care
Goshen Indiana, 46526, United States
IU Health Ball Memorial Hospital
Muncie Indiana, 47303, United States
Saint Luke's Hospital
Cedar Rapids Iowa, 52402, United States
Mercy Hospital
Cedar Rapids Iowa, 52403, United States
Iowa Methodist Medical Center
Des Moines Iowa, 50309, United States
University of Kansas Cancer Center
Kansas City Kansas, 66160, United States
Lawrence Memorial Hospital
Lawrence Kansas, 66044, United States
University of Kansas Cancer Center-Overland Park
Overland Park Kansas, 66210, United States
Ascension Via Christi Hospitals Wichita
Wichita Kansas, 67214, United States
Wesley Medical Center
Wichita Kansas, 67214, United States
University of Kentucky/Markey Cancer Center
Lexington Kentucky, 40536, United States
Tulane University Health Sciences Center
New Orleans Louisiana, 70112, United States
Anne Arundel Medical Center
Annapolis Maryland, 21401, United States
University of Maryland Medical Center
Baltimore Maryland, 21201, United States
University of Maryland/Greenebaum Cancer Center
Baltimore Maryland, 21201, United States
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore Maryland, 21237, United States
MedStar Good Samaritan Hospital
Baltimore Maryland, 21239, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore Maryland, 21287, United States
UM Upper Chesapeake Medical Center
Bel Air Maryland, 21014, United States
Central Maryland Radiation Oncology in Howard County
Columbia Maryland, 21044, United States
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie Maryland, 21061, United States
TidalHealth Richard A Henson Cancer Institute
Ocean Pines Maryland, 21811, United States
TidalHealth Peninsula Regional
Salisbury Maryland, 21801, United States
UM Saint Joseph Medical Center
Towson Maryland, 21204, United States
Lahey Hospital and Medical Center
Burlington Massachusetts, 01805, United States
Lowell General Hospital
Lowell Massachusetts, 01854, United States
UMass Memorial Medical Center - University Campus
Worcester Massachusetts, 01655, United States
Saint Joseph Mercy Hospital
Ann Arbor Michigan, 48106, United States
McLaren Cancer Institute-Bay City
Bay City Michigan, 48706, United States
Saint Joseph Mercy Brighton
Brighton Michigan, 48114, United States
Henry Ford Cancer Institute-Downriver
Brownstown Michigan, 48183, United States
Saint Joseph Mercy Chelsea
Chelsea Michigan, 48118, United States
GenesisCare USA - Clarkston
Clarkston Michigan, 48346, United States
McLaren Cancer Institute-Clarkston
Clarkston Michigan, 48346, United States
Henry Ford Macomb Hospital-Clinton Township
Clinton Township Michigan, 48038, United States
Beaumont Hospital - Dearborn
Dearborn Michigan, 48124, United States
Wayne State University/Karmanos Cancer Institute
Detroit Michigan, 48201, United States
Henry Ford Hospital
Detroit Michigan, 48202, United States
GenesisCare USA - Farmington Hills
Farmington Hills Michigan, 48334, United States
Genesys Hurley Cancer Institute
Flint Michigan, 48503, United States
McLaren Cancer Institute-Flint
Flint Michigan, 48532, United States
Mercy Health Saint Mary's
Grand Rapids Michigan, 49503, United States
Spectrum Health at Butterworth Campus
Grand Rapids Michigan, 49503, United States
West Michigan Cancer Center
Kalamazoo Michigan, 49007, United States
McLaren Cancer Institute-Lapeer Region
Lapeer Michigan, 48446, United States
Saint Mary Mercy Hospital
Livonia Michigan, 48154, United States
GenesisCare USA - Macomb
Macomb Michigan, 48044, United States
McLaren Cancer Institute-Macomb
Mount Clemens Michigan, 48043, United States
McLaren Cancer Institute-Central Michigan
Mount Pleasant Michigan, 48858, United States
Mercy Health Mercy Campus
Muskegon Michigan, 49444, United States
McLaren Cancer Institute-Owosso
Owosso Michigan, 48867, United States
McLaren Cancer Institute-Northern Michigan
Petoskey Michigan, 49770, United States
Saint Joseph Mercy Oakland
Pontiac Michigan, 48341, United States
McLaren-Port Huron
Port Huron Michigan, 48060, United States
William Beaumont Hospital-Royal Oak
Royal Oak Michigan, 48073, United States
Lakeland Medical Center Saint Joseph
Saint Joseph Michigan, 49085, United States
William Beaumont Hospital - Troy
Troy Michigan, 48085, United States
GenesisCare USA - Troy
Troy Michigan, 48098, United States
Henry Ford West Bloomfield Hospital
West Bloomfield Michigan, 48322, United States
Mayo Clinic Health System in Albert Lea
Albert Lea Minnesota, 56007, United States
Saint Luke's Hospital of Duluth
Duluth Minnesota, 55805, United States
Mayo Clinic Health Systems-Mankato
Mankato Minnesota, 56001, United States
Abbott-Northwestern Hospital
Minneapolis Minnesota, 55407, United States
Mayo Clinic Radiation Therapy-Northfield
Northfield Minnesota, 55057, United States
Mayo Clinic in Rochester
Rochester Minnesota, 55905, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park Minnesota, 55416, United States
Saint Francis Medical Center
Cape Girardeau Missouri, 63703, United States
Siteman Cancer Center at West County Hospital
Creve Coeur Missouri, 63141, United States
Freeman Health System
Joplin Missouri, 64804, United States
Saint Luke's Hospital of Kansas City
Kansas City Missouri, 64111, United States
North Kansas City Hospital
Kansas City Missouri, 64116, United States
University of Kansas Cancer Center - North
Kansas City Missouri, 64154, United States
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City Missouri, 64116, United States
Washington University School of Medicine
Saint Louis Missouri, 63110, United States
Siteman Cancer Center-South County
Saint Louis Missouri, 63129, United States
Missouri Baptist Medical Center
Saint Louis Missouri, 63131, United States
Mercy Hospital Saint Louis
Saint Louis Missouri, 63141, United States
Billings Clinic Cancer Center
Billings Montana, 59101, United States
Benefis Healthcare- Sletten Cancer Institute
Great Falls Montana, 59405, United States
Community Medical Hospital
Missoula Montana, 59804, United States
University of Nebraska Medical Center
Omaha Nebraska, 68198, United States
Renown Regional Medical Center
Reno Nevada, 89502, United States
Wentworth-Douglass Hospital
Dover New Hampshire, 03820, United States
Dartmouth Hitchcock Medical Center
Lebanon New Hampshire, 03756, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge New Jersey, 07920, United States
Englewood Hospital and Medical Center
Englewood New Jersey, 07631, United States
Memorial Sloan Kettering Monmouth
Middletown New Jersey, 07748, United States
Virtua Memorial
Mount Holly New Jersey, 08060, United States
Virtua Voorhees
Voorhees New Jersey, 08043, United States
University of New Mexico Cancer Center
Albuquerque New Mexico, 87102, United States
Northwell Health Imbert Cancer Center
Bay Shore New York, 11706, United States
Montefiore Medical Center-Einstein Campus
Bronx New York, 10461, United States
Montefiore Medical Center - Moses Campus
Bronx New York, 10467, United States
New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn New York, 11215, United States
Roswell Park Cancer Institute
Buffalo New York, 14263, United States
Memorial Sloan Kettering Commack
Commack New York, 11725, United States
Arnot Ogden Medical Center/Falck Cancer Center
Elmira New York, 14905, United States
Memorial Sloan Kettering Westchester
Harrison New York, 10604, United States
Northwell Health/Center for Advanced Medicine
Lake Success New York, 11042, United States
Lenox Hill Hospital
New York New York, 10021, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York New York, 10032, United States
Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States
University of Rochester
Rochester New York, 14642, United States
Staten Island University Hospital
Staten Island New York, 10305, United States
State University of New York Upstate Medical University
Syracuse New York, 13210, United States
Memorial Sloan Kettering Nassau
Uniondale New York, 11553, United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte North Carolina, 28203, United States
Atrium Health Pineville/LCI-Pineville
Charlotte North Carolina, 28210, United States
Atrium Health University City/LCI-University
Charlotte North Carolina, 28262, United States
Atrium Health Cabarrus/LCI-Concord
Concord North Carolina, 28025, United States
Atrium Health Union/LCI-Union
Monroe North Carolina, 28112, United States
Atrium Health Cleveland/LCI-Cleveland
Shelby North Carolina, 28150, United States
Sanford Bismarck Medical Center
Bismarck North Dakota, 58501, United States
Sanford Roger Maris Cancer Center
Fargo North Dakota, 58122, United States
Summa Health System - Akron Campus
Akron Ohio, 44304, United States
Cleveland Clinic Akron General
Akron Ohio, 44307, United States
Geauga Hospital
Chardon Ohio, 44024, United States
Adena Regional Medical Center
Chillicothe Ohio, 45601, United States
Case Western Reserve University
Cleveland Ohio, 44106, United States
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland Ohio, 44111, United States
Cleveland Clinic Foundation
Cleveland Ohio, 44195, United States
Ohio State University Comprehensive Cancer Center
Columbus Ohio, 43210, United States
Mount Carmel Health Center West
Columbus Ohio, 43222, United States
Dayton Physician LLC-Miami Valley Hospital North
Dayton Ohio, 45415, United States
Mercy Cancer Center-Elyria
Elyria Ohio, 44035, United States
Cleveland Clinic Cancer Center Independence
Independence Ohio, 44131, United States
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor Ohio, 44060, United States
UH Seidman Cancer Center at Southwest General Hospital
Middleburg Heights Ohio, 44130, United States
University Hospitals Parma Medical Center
Parma Ohio, 44129, United States
Cleveland Clinic Cancer Center Strongsville
Strongsville Ohio, 44136, United States
UHHS-Westlake Medical Center
Westlake Ohio, 44145, United States
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster Ohio, 44691, United States
University of Oklahoma Health Sciences Center
Oklahoma City Oklahoma, 73104, United States
Legacy Mount Hood Medical Center
Gresham Oregon, 97030, United States
Legacy Good Samaritan Hospital and Medical Center
Portland Oregon, 97210, United States
Jefferson Abington Hospital
Abington Pennsylvania, 19001, United States
Crozer-Keystone Regional Cancer Center at Broomall
Broomall Pennsylvania, 19008, United States
Bryn Mawr Hospital
Bryn Mawr Pennsylvania, 19010, United States
Christiana Care Health System-Concord Health Center
Chadds Ford Pennsylvania, 19317, United States
Geisinger Medical Center
Danville Pennsylvania, 17822, United States
Northeast Radiation Oncology Center
Dunmore Pennsylvania, 18512, United States
Adams Cancer Center
Gettysburg Pennsylvania, 17325, United States
Crozer Regional Cancer Center at Brinton Lake
Glen Mills Pennsylvania, 19342, United States
Geisinger Medical Oncology-Lewisburg
Lewisburg Pennsylvania, 17837, United States
Riddle Memorial Hospital
Media Pennsylvania, 19063, United States
Thomas Jefferson University Hospital
Philadelphia Pennsylvania, 19107, United States
Fox Chase Cancer Center
Philadelphia Pennsylvania, 19111, United States
Jefferson Torresdale Hospital
Philadelphia Pennsylvania, 19114, United States
Temple University Hospital
Philadelphia Pennsylvania, 19140, United States
Penn State Health Saint Joseph Medical Center
Reading Pennsylvania, 19605, United States
Reading Hospital
West Reading Pennsylvania, 19611, United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre Pennsylvania, 18711, United States
Lankenau Medical Center
Wynnewood Pennsylvania, 19096, United States
WellSpan Health-York Cancer Center
York Pennsylvania, 17403, United States
AnMed Health Cancer Center
Anderson South Carolina, 29621, United States
Prisma Health Cancer Institute - Spartanburg
Boiling Springs South Carolina, 29316, United States
Prisma Health Cancer Institute - Faris
Greenville South Carolina, 29605, United States
Prisma Health Cancer Institute - Eastside
Greenville South Carolina, 29615, United States
Self Regional Healthcare
Greenwood South Carolina, 29646, United States
The Radiation Oncology Center-Hilton Head/Bluffton
Hilton Head Island South Carolina, 29926, United States
Lancaster Radiation Therapy Center
Lancaster South Carolina, 29720, United States
Rock Hill Radiation Therapy Center
Rock Hill South Carolina, 29730, United States
Rapid City Regional Hospital
Rapid City South Dakota, 57701, United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls South Dakota, 57117, United States
Thompson Cancer Survival Center
Knoxville Tennessee, 37916, United States
Blount Memorial Hospital
Maryville Tennessee, 37804, United States
Vanderbilt University/Ingram Cancer Center
Nashville Tennessee, 37232, United States
University of Texas Medical Branch
Galveston Texas, 77555, United States
M D Anderson Cancer Center
Houston Texas, 77030, United States
UTMB Cancer Center at Victory Lakes
League City Texas, 77573, United States
Ogden Regional Medical Center
Ogden Utah, 84405, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City Utah, 84112, United States
Central Vermont Medical Center/National Life Cancer Treatment
Berlin Vermont, 05602, United States
University of Vermont Medical Center
Burlington Vermont, 05401, United States
Norris Cotton Cancer Center-North
Saint Johnsbury Vermont, 05819, United States
Virginia Commonwealth University/Massey Cancer Center
Richmond Virginia, 23298, United States
West Virginia University Healthcare
Morgantown West Virginia, 26506, United States
Wheeling Hospital/Schiffler Cancer Center
Wheeling West Virginia, 26003, United States
Langlade Hospital and Cancer Center
Antigo Wisconsin, 54409, United States
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield Wisconsin, 53045, United States
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire Wisconsin, 54701, United States
Mayo Clinic Health System Eau Claire Hospital-Luther Campus
Eau Claire Wisconsin, 54703, United States
Ascension Saint Francis - Reiman Cancer Center
Franklin Wisconsin, 53132, United States
Aurora Cancer Care-Grafton
Grafton Wisconsin, 53024, United States
Aurora BayCare Medical Center
Green Bay Wisconsin, 54311, United States
UW Cancer Center Johnson Creek
Johnson Creek Wisconsin, 53038, United States
Aurora Cancer Care-Kenosha South
Kenosha Wisconsin, 53142, United States
Gundersen Lutheran Medical Center
La Crosse Wisconsin, 54601, United States
Mayo Clinic Health System-Franciscan Healthcare
La Crosse Wisconsin, 54601, United States
University of Wisconsin Hospital and Clinics
Madison Wisconsin, 53792, United States
Froedtert Menomonee Falls Hospital
Menomonee Falls Wisconsin, 53051, United States
Aurora Saint Luke's Medical Center
Milwaukee Wisconsin, 53215, United States
Medical College of Wisconsin
Milwaukee Wisconsin, 53226, United States
Aurora Sinai Medical Center
Milwaukee Wisconsin, 53233, United States
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh Wisconsin, 54904, United States
Ascension All Saints Hospital
Racine Wisconsin, 53405, United States
Marshfield Clinic Stevens Point Center
Stevens Point Wisconsin, 54482, United States
Aurora Medical Center in Summit
Summit Wisconsin, 53066, United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers Wisconsin, 54241, United States
Aspirus Regional Cancer Center
Wausau Wisconsin, 54401, United States
Aurora West Allis Medical Center
West Allis Wisconsin, 53227, United States
Diagnostic and Treatment Center
Weston Wisconsin, 54476, United States
Marshfield Medical Center - Weston
Weston Wisconsin, 54476, United States
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids Wisconsin, 54494, United States
Kingston Health Sciences Centre
Kingston Ontario, K7L 2, Canada
London Regional Cancer Program
London Ontario, N6A 4, Canada
Stronach Regional Health Centre at Southlake
Newmarket Ontario, L3Y 2, Canada
Ottawa Hospital and Cancer Center-General Campus
Ottawa Ontario, K1H 8, Canada
University Health Network-Princess Margaret Hospital
Toronto Ontario, M5G 2, Canada
CHUM - Hopital Notre-Dame
Montreal Quebec, H2L 4, Canada
McGill University Department of Oncology
Montreal Quebec, H2W 1, Canada
CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal Quebec, H2X 3, Canada
The Research Institute of the McGill University Health Centre (MUHC)
Montreal Quebec, H3H 2, Canada
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Quebec City Quebec, G1R 2, Canada
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke Quebec, J1H 5, Canada
Allan Blair Cancer Centre
Regina Saskatchewan, S4T 7, Canada
Saskatoon Cancer Centre
Saskatoon Saskatchewan, S7N 4, Canada

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 2

Estimated Enrollment:

418

Study ID:

NCT02635009

Recruitment Status:

Active, not recruiting

Sponsor:


NRG Oncology

How clear is this clinincal trial information?

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