Melanoma Clinical Trial
A Study of BMS-986253 in Combination With Nivolumab or Nivolumab Plus Ipilimumab in Advanced Cancers
Summary
The purpose of this study is to investigate experimental medication BMS-986253 in combination with Nivolumab or Nivolumab plus Ipilimumab in participants with advanced cancers.
Eligibility Criteria
Inclusion Criteria:
Histologic or cytologic confirmation of a solid tumor that is advanced (metastatic, recurrent and/or unresectable) with measurable disease per RECIST v1.1
At least 1 lesion accessible for biopsy
Eastern Cooperative Oncology Group Performance Status of 0 or 1
Exclusion Criteria:
Participants with CNS metastases as the only site of active disease (Participants with controlled brain metastases; however, will be allowed to enroll)
Participants with active, known or suspected autoimmune disease
Participants with conditions requiring systemic treatment with either corticosteroids (> 10mg prednisone equivalents) or other immunosuppressive medications within 14 days of study treatment administration
Participants with a known history of testing positive for Human Immunodeficiency Virus (HIV) or known Acquired Immunodeficiency Syndrome (AIDS)
Cytotoxic agents, unless at least 4 weeks have elapsed from last dose of prior anti-cancer therapy and initiation of study therapy
Other protocol defined inclusion/exclusion criteria could apply
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There are 80 Locations for this study
Aurora Colorado, 80045, United States
Lakewood Colorado, 80228, United States
Miami Beach Florida, 33140, United States
Marietta Georgia, 30060, United States More Info
Columbia Maryland, 21044, United States
Lutherville Maryland, 21093, United States More Info
Ann Arbor Michigan, 48109, United States
Las Vegas Nevada, 89169, United States
Hackensack New Jersey, 07601, United States More Info
New Brunswick New Jersey, 08903, United States
New York New York, 10029, United States
New York New York, 10032, United States
Eugene Oregon, 97401, United States
Philadelphia Pennsylvania, 19111, United States
Greenville South Carolina, 29615, United States
Austin Texas, 78705, United States
Dallas Texas, 75246, United States
Fort Worth Texas, 76104, United States
Houston Texas, 77030, United States
San Antonio Texas, 78240, United States
Tyler Texas, 75702, United States
Fairfax Virginia, 22031, United States
Norfolk Virginia, 23502, United States
Wollstonecraft New South Wales, 2065, Australia More Info
Contact
Toronto Ontario, M5G 1, Canada
Gerlingen , 70839, Germany
Hamburg , 20246, Germany
Mainz , 55131, Germany
Madrid , 28034, Spain
Manchester Greater Manchester, M20 4, United Kingdom More Info
Contact
Birmingham West Midlands, B15 2, United Kingdom More Info
Contact
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