Melanoma Clinical Trial

A Study of Modakafusp Alfa (TAK-573) Given by Itself and Together With Pembrolizumab in Adults With Advanced or Metastatic Solid Tumors

Summary

This study has 2 phases.

The main aims of Phase 1b are:

to check for side effects from modakafusp alfa in adults with locally advanced or metastatic solid tumors.
to learn how much modakafusp alfa adults can receive without getting any major side effects from it.

The main aims of Phase 2 are:

to check for side effects from modakafusp alfa when given together with pembrolizumab in adults with metastatic cutaneous melanoma which cannot be completely removed by surgery.
to learn how these medicines improve their symptoms.

Participants will receive modakafusp alfa for up to 1 year (Phase 1b) or modakafusp alfa given together with pembrolizumab for up to 2 years (Phase 2). Those whose symptoms improve might continue treatment for longer.

In both phases of the study, participants will revisit the study clinic within 30 days after their last dose or before they start other cancer treatment, whichever happens first.

View Full Description

Full Description

The drug being tested in this study is called modakafusp alfa (TAK-573). Modakafusp alfa is being tested to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and antitumor activity as single agent (SA) or in combination with pembrolizumab in participants with locally advanced or metastatic solid tumors. The study will consist of 2 phases: Phase 1b dose escalation and a Phase 2 dose expansion.

The study will enroll approximately 114 participants (approximately 30 participants in Phase 1b dose escalation phase; 3-9 participants in safety-lead in and 25 participants for each expansion cohort (3 cohorts) of Phase 2.

The dose escalation phase will enroll participants with solid tumors. The dose escalation phase is to evaluate SA recommended phase 2 dose (RP2D).

The dose expansion phase in combination with pembrolizumab will be initiated with a safety lead-in phase once the SA RP2D is determined for modakafusp alfa. The dose expansion will include participants with one of following 3 disease indications:

I. Unresectable/metastatic cutaneous melanoma with primary resistance to no more than 2 prior lines of anti-disease programmed cell death protein 1 (PD1) containing treatments in the metastatic setting.

II. Unresectable/metastatic cutaneous melanoma with acquired resistance to no more than 2 prior lines of anti-PD1 containing treatments in the metastatic setting.

III. Unresectable/metastatic cutaneous melanoma naïve to prior anti-PD1 containing treatments in the metastatic setting.

This multi-center trial will be conducted in the United States and Australia. Participants with demonstrated clinical benefit may continue treatment beyond 1 year for Phase 1b and 2 years for Phase 2 if approved by the sponsor. The overall time to participate in this study is 55 months. All participants will make an end of treatment (EOT) visit 30 days after receiving their last dose of study drug or before the start of subsequent systemic anticancer therapy, whichever occurs first for a safety follow up assessment.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
For both the dose escalation and expansion cohort phases of the study, eligible participants must have histologically confirmed advanced (locoregionally recurrent, not amenable to curative therapy) or metastatic solid tumors.
Measurable disease per RECIST v1.1. At least 1 target lesion amenable for biopsy is required for enrollment in phase 1b. A minimum of 1 target lesion for response assessment is required for enrollment in phase 2. A separate lesion amenable for biopsy is required for enrollment in phase 2 for cohorts I and II post futility analysis and for all participants (safety lead-in and expansion) with subgroup III melanoma.
Phase 1b Dose Escalation: Participants with histologically confirmed advanced locally (locoregionally recurrent, not amenable to curative therapy) or metastatic solid tumors.

Phase 2 Dose Expansion:

The combination cohorts, including participants in the safety-lead phase, will enroll participants with unresectable/metastatic melanoma in the following subgroups:

I. Unresectable/metastatic histologically confirmed cutaneous melanoma with primary resistance to no more than 2 prior lines of anti-PD1 containing treatments in the metastatic setting.

II. Unresectable/metastatic histologically confirmed cutaneous melanoma with acquired resistance to no more than 2 prior lines of anti-PD1 containing treatments in the metastatic setting.

III. Unresectable/metastatic histologically confirmed cutaneous melanoma naive to prior anti-PD1 containing treatments in the metastatic setting.

Participants with BRAF V600E mutant melanoma may have received prior BRAF inhibitor therapy.
For the expansion cohorts I and II, there is no limitation of total number of prior line(s) of therapy, but the number of prior line(s) containing anti-PD1 must be ≤2 in the metastatic setting.
For the expansion cohort III, participants who received an anti-PD-1 treatment in the adjuvant setting must have completed that treatment at least 6 months prior to enrollment and must not have progressed on the anti-PD1 adjuvant treatment.
Primary resistance is defined as a best response of PD or SD less than (<) 6 months to an anti-PD1 alone or in combination with other agents (that is, CTLA4) in the initial anti-PD1 containing treatment.
Acquired resistance is defined as a progression following a best response of CR, PR or SD>6 months to a prior anti-PD1 alone or in combination with other agents (that is, CTLA4).

Exclusion Criteria:

Persistent toxicity from previous treatments that has not resolved to less than or equal to (<=) CTCAE version 5.0 Grade 1 prior to administration of modakafusp alfa, except for alopecia, Grade 2 neuropathy, and Grade 2 asthenia/fatigue, or autoimmune endocrinopathies with stable replacement therapy.
History of any of the following <=6 months before first dose modakafusp alfa: New York Heart Association (NYHA) Grade III or IV congestive heart failure, unstable angina, myocardial infarction, unstable symptomatic ischemic heart disease, any ongoing symptomatic cardiac arrhythmias of Grade >2, pulmonary embolism, or symptomatic cerebrovascular events, or any other serious cardiac condition (example, symptomatic pericardial effusion or restrictive cardiomyopathy). Chronic, stable atrial fibrillation on stable anticoagulant therapy, including low molecular-weight heparin, is allowed.
Baseline QT interval with Fridericia's correction (QTcF) greater than (>) 480 millisecond (msec) (Grade >=2), history of congenital long QT syndrome, or torsades de pointes.
Patients with acral lentiginous melanoma are excluded in phase 2 except for the safety lead-in phase.
Ongoing or active infection.
Known history of human immunodeficiency virus (HIV) infection or any other relevant congenital or acquired immunodeficiency. Testing during screening period is required only if indicated by specific local regulations or investigator's criteria.
Known hepatitis B (HBV) surface antigen seropositive or detectable hepatitis C infection viral load. Note: Participants with a positive HBV core antibody can be enrolled but must have an undetectable hepatitis B viral load.
Autoimmune disease requiring systemic immunosuppressive therapy. Participants with immune mediated endocrine deficiency from previous therapy with stable hormone replacement are exceptions.

Study is for people with:

Melanoma

Phase:

Phase 1

Estimated Enrollment:

114

Study ID:

NCT04157517

Recruitment Status:

Recruiting

Sponsor:

Takeda

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There are 20 Locations for this study

See Locations Near You

City of Hope Comprehensive Cancer Center - Duarte
Duarte California, 91010, United States More Info
Site Contact
Contact
626-218-9200
[email protected]
Yang Xing
Principal Investigator
University of California San Diego Moores Cancer Center
La Jolla California, 92093, United States More Info
Site Contact
Contact
858-552-7521
[email protected]
Gregory Daniels
Principal Investigator
The Angeles Clinic and Research Institute - West Los Angeles Office
Los Angeles California, 90025, United States More Info
Site Contact
Contact
310-582-7900
[email protected]
Inderjit Mehmi
Principal Investigator
University of Colorado Health Memorial Hospital Central
Colorado Springs Colorado, 80909, United States More Info
Site Contact
Contact
719-304-4144
[email protected]
Robert Hoyer
Principal Investigator
Yale Cancer Center
New Haven Connecticut, 06520, United States
Sylvester Comprehensive Cancer Center
Miami Florida, 33136, United States More Info
Site Contact
Contact
305-284-2211
[email protected]
Jose Lutzky
Principal Investigator
Orlando Health Cancer Institute
Orlando Florida, 32806, United States More Info
Site Contact
Contact
321-841-8470
[email protected]
Sajeve Thomas
Principal Investigator
HealthPartners Institute
Bloomington Minnesota, 55425, United States
Morristown Medical Center
Morristown New Jersey, 07960, United States More Info
Site Contact
Contact
973-971-6298
[email protected]
Eric Whitman
Principal Investigator
Cleveland Clinic Main Campus
Cleveland Ohio, 44195, United States More Info
Site Contact
Contact
216-444-2273
[email protected]
Brian Gastman
Principal Investigator
University of Pittsburgh Medical Center
Pittsburgh Pennsylvania, 15232, United States More Info
Site Contact
Contact
412-623-7707
[email protected]
John Kirkwood
Principal Investigator
Avera Cancer Institute
Sioux Falls South Dakota, 57105, United States More Info
Site Contact
Contact
605-322-6900
[email protected]
Heidi McKean
Principal Investigator
Sarah Cannon Research Institute
Nashville Tennessee, 37203, United States More Info
Site Contact
Contact
615-329-7274
[email protected]
Meredith McKean
Principal Investigator
Mary Crowley Cancer Research
Dallas Texas, 75230, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center
Dallas Texas, 75246, United States More Info
Site Contact
Contact
214-370-1800
[email protected]
Charles Cowey
Principal Investigator
NEXT Oncology
San Antonio Texas, 78240, United States
Intermountain Medical Center
Murray Utah, 84107, United States More Info
Site Contact
Contact
801-507-3630
[email protected]
David Gill
Principal Investigator
West Virginia University Health Sciences Campus
Morgantown West Virginia, 26506, United States More Info
Site Contact
Contact
304-598-6984
[email protected]
Joanna Kolodney
Principal Investigator
The Queen Elizabeth Hospital
Woodville South South Australia, 5011, Australia More Info
Rachel Roberts-Thomson
Principal Investigator
Ballarat Regional Integrated Cancer Center
Ballarat Victoria, 3350, Australia More Info
Site Contact
Contact
61353398000
[email protected]
Prashanth Prithviraj
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Melanoma

Phase:

Phase 1

Estimated Enrollment:

114

Study ID:

NCT04157517

Recruitment Status:

Recruiting

Sponsor:


Takeda

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