Melanoma Clinical Trial
A Study of SAR444245 Combined With Cemiplimab for the Treatment of Participants With Various Advanced Skin Cancers (Pegathor Skin 201)
-To determine the antitumor activity of SAR444245 in combination with cemiplimab.
To determine the recommended phase 2 dose and to assess the safety profile of SAR444245 when combined with cemiplimab
To assess other indicators of antitumor activity
To assess the concentrations of SAR444245 when given in combination with cemiplimab
To assess the immunogenicity of SAR444245
To assess active concentrations of cemiplimab when given in combination with SAR444245
The duration of the study for an individual patient will start from the signature of the main informed consent and include a screening period of up to 28 days, a treatment period [max 35 cycles or until PD], an end-of-treatment visit 30 days + 7 days following the last administration of study drug (or until the patient receives another anticancer therapy, whichever is earlier), and a follow-up visit 3 months after treatment discontinuation and every 3 months following, until disease progression, or initiation of another antitumor treatment, or final cohort cut-off, whichever is earlier
Participant must be ≥18 years of age (or country's legal age of majority if >18 years), at the time of signing the informed consent.
Cohort A: Histologically confirmed unresectable locally advanced or metastatic melanoma that are not amenable to local therapy
Cohort B: Histologically confirmed metastatic CSCC or locally advanced
CSCC that are not candidates for curative surgery or radiation. Special considerations for the following categories:
Participants with tumors arising on the cutaneous hair (non-glabrous) bearing lip with extension onto dry red lip (vermillion) may be eligible after communication with and approval from the Sponsor
Participants with the primary site is nose are only eligible if the primary site was skin, not nasal mucosa with outward extension to skin (the Investigator confirmed)
Participants with mixed histology in which the predominant histology is invasive CSCC may be eligible after communication with and approval from the Sponsor
Participants in both cohorts must have at least one measurable lesion
Provision of tumor tissue:
For participants in the dose escalation:
16 µg/kg: at screening, biopsy is optional but highly recommended; and on-treatment not required
24 µg/kg: at screening, biopsy is mandatory and on-treatment, optional but highly recommended
For the other participants : Mandatory baseline biopsy for the participants to enroll in cohort A with skin metastasis and in cohort B. Mandatory on-treatment biopsy for participants in Cohort A with skin metastasis and participants in Cohort B.
Females are eligible to participate if they are not pregnant or breastfeeding, not a woman of childbearing potential (WOCBP) or are a WOCBP that agrees: to use approved contraception method and submit to regular pregnancy testing prior to treatment and for at least 180 days after discontinuing study treatment and to refrain from donating or cryopreserving eggs for 180 days after discontinuing study treatment.
Males are eligible to participate if they agree to refrain from donating or cryopreserving sperm, and either abstain from heterosexual intercourse OR use approved contraception during study treatment and for at least 210 days after discontinuing study treatment.
Capable of giving signed informed consent
Participants are excluded from the study if any of the following criteria apply:
Eastern Cooperative Oncology Group (ECOG) performance status of ≥2
Poor organ function
Participants with baseline SpO2 ≤92%
Active brain metastases or leptomeningeal disease.
History of allogenic tissue/solid organ transplant.
Last administration of prior antitumor therapy or any investigational treatment within 28 days or less than 5 times the half-life, whichever is shorter; major surgery or local intervention within 28 days.
History of lung disease
Comorbidity requiring corticosteroid therapy
Antibiotic use (excluding topical antibiotics) ≤14 days prior to first dose of IMP
Severe or unstable cardiac condition within 6 months prior to starting study treatment
Active, known, or suspected autoimmune disease that has required systemic treatment in the past 2 years
Known second malignancy either progressing or requiring active treatment within the last 3 years
For both cohorts:
Prior immune checkpoint inhibitors except in the context of adjuvant or neoadjuvant; Participants who were on control arm of a study with an investigational anti-PD-1/PD-L1 are eligible.
Received adjuvant or neoadjuvant therapy during the 6 months prior to development of metastatic disease.
For Cohort A: any prior systemic treatment for advanced/metastatic disease
For Cohort B: >2 prior lines of any systemic treatment for advanced/metastatic disease
Inability to undergo any contrast-enhanced radiologic response assessment
Receipt of a live-virus vaccination within 28 days of planned treatment start. Seasonal flu vaccines that do not contain live virus are permitted
The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
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There are 35 Locations for this study
Beverly Hills California, 90211, United States
Orlando Florida, 32804, United States
Minneapolis Minnesota, 55455, United States
New York New York, 10029, United States
Macquarie Park New South Wales, 2109, Australia
Heidelberg West Victoria, 3081, Australia
Temuco La Araucanía, 48008, Chile
Santaigo Reg Metropolitana De Santiago, 82414, Chile
Santiago Reg Metropolitana De Santiago, 75009, Chile
Santiago Reg Metropolitana De Santiago, 84203, Chile
Santiago Reg Metropolitana De Santiago, , Chile
Bobigny , 93009, France
Dijon , 21079, France
Lille , 59037, France
Nantes , 44093, France
Pierre Benite , 69495, France
Berlin , 10117, Germany
Hamburg , 20246, Germany
Mannheim , 68167, Germany
Minden , 32429, Germany
München , 80337, Germany
Tübingen , 72076, Germany
Dublin 4 Dublin, , Ireland
Meldola (FC) Emilia-Romagna, 47014, Italy
Milano , 20141, Italy
Napoli , 80131, Italy
Perugia , 06126, Italy
Siena , 53100, Italy
Lisboa , 1649-, Portugal
Porto , 4200-, Portugal
Moscow , 11547, Russian Federation
Moscow , 12909, Russian Federation
Saint -Petersburg , 19775, Russian Federation
Barcelona Barcelona [Barcelona], 08035, Spain
Barcelona Barcelona [Barcelona], 08036, Spain
Hospitalet de Llobregat Barcelona [Barcelona], 08908, Spain
Santander Cantabria, 39008, Spain
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