Melanoma Clinical Trial

FLX475 in Combination With Ipilimumab in Advanced Melanoma

Summary

This clinical trial is a Phase 2, open-label study to determine the anti-tumor activity of FLX475 in combination with ipilimumab in subjects with advanced melanoma previously treated with an anti-PD-1 or anti-PD-L1 agent.

The study will be conducted starting with a safety run-in portion in which 6 eligible subjects will be enrolled and treated for at least one 3-week cycle to determine if the safety profile of FLX475+ipilimumab is acceptable to complete enrollment of the approximately 20-subject study.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Stage IV or unresectable Stage III advanced melanoma
Prior treatment with at least 2 months of anti-PD-(L)1 agent
Measurable disease at baseline
Tumor available for biopsy

Exclusion Criteria:

History of allergy or severe hypersensitivity to biologic agents
History of Grade 3-4 immune-related adverse events leading to discontinuation of prior immunotherapy
Prior treatment with ipilimumab or other (cytotoxic T-lymphocyte-associated antigen 4) CTLA-4 antagonists

Study is for people with:

Melanoma

Phase:

Phase 2

Estimated Enrollment:

6

Study ID:

NCT04894994

Recruitment Status:

Terminated

Sponsor:

RAPT Therapeutics, Inc.

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There are 4 Locations for this study

See Locations Near You

University of California, Los Angeles
Los Angeles California, 90095, United States
Moffitt Cancer Center
Tampa Florida, 33612, United States
Washington University School of Medicine St. Louis
Saint Louis Missouri, 63110, United States
The University of Texas MD Anderson Cancer Center
Houston Texas, 77030, United States

How clear is this clinincal trial information?

Study is for people with:

Melanoma

Phase:

Phase 2

Estimated Enrollment:

6

Study ID:

NCT04894994

Recruitment Status:

Terminated

Sponsor:


RAPT Therapeutics, Inc.

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.