Melanoma Clinical Trial

Leveraging ctDNA Analysis to Improve Early Detection of Cancer Recurrence in the High-Risk Melanoma Setting

Summary

To generate meaningful data regarding ctDNA that would infer risk of recurrence in stage III melanoma patients.

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Full Description

Cancer cells harbor and can acquire potentially hundreds of mutations, many of whom are found in the ctDNA. Circulating tumor DNA (ctDNA) holds the promise for the 50% of participants who do not need adjuvant therapies - participants could be monitored to ensure no increase in ctDNA. Participants treated could then be followed for the earliest possible blood level signs of recurrence (incr. ctDNA) and more quickly be switched to more effective therapies. Further, the treating physician could hold therapy until the first signs of ctDNA based recurrence for those participants that would benefit.

Blood sample from a biobank will be used to identify to monitor ctDNA. These blood samples were drawn at baseline, 3 months, 6 months and 18 months.

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Eligibility Criteria

Inclusion Criteria:

Age ≥18
Confirmed fully resected Stage IIIb-IV cutaneous melanoma; including patients treated neoadjuvantly within three months prior to resection.

Exclusion Criteria:

• Treatment plan inconsistent with the standard of care systemic adjuvant therapies 4.0 Study Design

Study is for people with:

Melanoma

Estimated Enrollment:

150

Study ID:

NCT05079113

Recruitment Status:

Recruiting

Sponsor:

Case Comprehensive Cancer Center

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There is 1 Location for this study

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Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer center
Cleveland Ohio, 44195, United States More Info
Brian Gastman, MD
Contact
866-223-8100
[email protected]

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Study is for people with:

Melanoma

Estimated Enrollment:

150

Study ID:

NCT05079113

Recruitment Status:

Recruiting

Sponsor:


Case Comprehensive Cancer Center

How clear is this clinincal trial information?

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