Melanoma Clinical Trial

Optical Clearing of the Skin in Conjunction With Laser Treatments

Summary

The research hypothesis is that topical application of a mixture of pre-polymers of polypropylene glycol and polyethylene glycol (an optical clearing agent) will reduce skin light scattering, increasing the amount of light reaching the target for diagnostic as well as therapeutic purposes.

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Full Description

The researchers expect that application of the optical clearing agent for treatment of benign vascular lesions, tattoos, nevus of Ota, hypertrichosis, scars, acne and sebaceous hyperplasia will result in

decreased reflectance of the predominant color from the surface of skin (decreased red light scattering in case of benign vascular lesions, etc) as compared to the control group.
greater Optical Coherence Tomography a non-invasive light based imaging method imaging depth as compared to the control group.
greater improvement in the treatment outcome (decrease in the erythema index following laser treatment of vascular lesions as compared to the laser alone group; improved lightening of the tattoo or nevus of Ota as compared to the laser treatment alone group; significant decrease in hair re-growth as compared to laser treatment alone in patients seeking hair removal; greater improvement of scars, acne and sebaceous hyperplasia).

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Eligibility Criteria

Inclusion Criteria:

Adult 18 years and older
Lesion diagnoses in an area measuring 3 cm2 or more on any body site
Apparent good health

Exclusion Criteria:

Pregnant women
History of cutaneous photosensitivity
History of photodermatoses

Study is for people with:

Melanoma

Phase:

Phase 1

Estimated Enrollment:

35

Study ID:

NCT00580736

Recruitment Status:

Completed

Sponsor:

University of California, Irvine

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There is 1 Location for this study

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Beckman Laser Institute Medical and Surgical Clinic
Irvine California, 92612, United States

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Study is for people with:

Melanoma

Phase:

Phase 1

Estimated Enrollment:

35

Study ID:

NCT00580736

Recruitment Status:

Completed

Sponsor:


University of California, Irvine

How clear is this clinincal trial information?

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