Multiple Myeloma Clinical Trial

A Study to Evaluate CC-92480, Bortezomib and Dexamethasone (480Vd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Summary

The purpose of this study is to compare the efficacy and safety of CC-92480, bortezomib and dexamethasone (480Vd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Participant has documented diagnosis of MM and measurable disease, defined as any of the following:

M-protein ≥ 0.5 grams per deciliter (g/dL) by serum protein electrophoresis (sPEP) or
M-protein ≥ 200 milligrams (mg) per 24-hour urine collection by urine protein electrophoresis (uPEP)
For participants without measurable disease in sPEP or uPEP: serum free light chain (sFLC) levels > 100 mg/L (10 mg/dL) involved light chain and an abnormal kappa/lambda FLC ratio.
Participants received 1 to 3 prior lines of antimyeloma therapy.
Participants achieved minimal response [MR] or better to at least 1 prior antimyeloma therapy.

Exclusion Criteria:

Participant has had progression during treatment or within 60 days of the last dose of a proteasome inhibitor.
For participants with prior treatment of a bortezomib containing regimen, the best response achieved was not a minimal response (MR) or better, or participant discontinued bortezomib due to toxicity.
Participant has had prior treatment with CC-92480 or pomalidomide.

Other protocol-defined criteria apply.

Study is for people with:

Multiple Myeloma

Phase:

Phase 3

Estimated Enrollment:

760

Study ID:

NCT05519085

Recruitment Status:

Recruiting

Sponsor:

Bristol-Myers Squibb

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There are 120 Locations for this study

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Local Institution
Fayetteville Arkansas, 72703, United States More Info
Site 0095
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Sharp Memorial Hospital
San Diego California, 92123, United States More Info
Edward Huynh, Site 0272
Contact
858-939-6622
Private Practice - Dr. James R. Berenson
West Hollywood California, 90069, United States More Info
James Berenson, Site 0273
Contact
310-623-1222
Yale University School of Medicine
New Haven Connecticut, 06510, United States
Advanced Research
Tamarac Florida, 33321, United States More Info
Sumit Sawhney, Site 0303
Contact
954-204-0052
University Cancer & Blood Center, LLC
Athens Georgia, 30607, United States More Info
PETROS NIKOLINAKOS, Site 0211
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706-353-2990
Local Institution
Marietta Georgia, 30060, United States More Info
Site 0048
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University of Iowa
Iowa City Iowa, 52242, United States More Info
Chris Strouse, Site 0244
Contact
630-917-8956
Tulane Cancer Center
New Orleans Louisiana, 70112, United States More Info
Hana Safah, Site 0255
Contact
504-988-6070
Dana-Farber Cancer Institute
Boston Massachusetts, 02215, United States More Info
Monique Hartley-Brown, Site 0246
Contact
857-299-5736
University of Michigan
Ann Arbor Michigan, 48109, United States More Info
Matthew Pianko, Site 0271
Contact
734-647-0118
Hattiesburg Clinic Hematology/Oncology
Hattiesburg Mississippi, 39401, United States More Info
John Hrom, Site 0088
Contact
601-261-1700
The University of Mississippi Medical Center
Jackson Mississippi, 39213, United States
Mercy Research - David C. Pratt Cancer Center
Saint Louis Missouri, 63141, United States More Info
Bethany Sleckman, Site 0266
Contact
314-251-7057
Astera Cancer Care
East Brunswick New Jersey, 08816, United States More Info
Bruno Fang, Site 0288
Contact
732-672-6405
University of New Mexico Comprehensive Cancer Center
Albuquerque New Mexico, 87131, United States More Info
Shashank Cingam, Site 0302
Contact
505-272-4946
Erie County Medical Center
Buffalo New York, 14215, United States
R.J. Zuckerberg Cancer Center
Lake Success New York, 11042, United States More Info
Maria Nieto, Site 0257
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516-734-8900
Great Lakes Cancer Care
Williamsville New York, 14221, United States More Info
Robert Setlik, Site 0274
Contact
210-842-7276
Duke Cancer Institute
Durham North Carolina, 27710, United States More Info
Cristina Gasparetto, Site 0260
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919-668-1017
Cleveland Clinic
Cleveland Ohio, 44195, United States More Info
Faiz Anwer, Site 0076
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216-445-1469
AHN West Penn Hospital
Pittsburgh Pennsylvania, 15224, United States More Info
Santhosh Sadashiv, Site 0270
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412-578-4484
WellSpan Oncology Research
York Pennsylvania, 17403, United States More Info
Joseph Kannarkatt, Site 0264
Contact
717-741-9229
The West Clinic, PLLC dba West Cancer Center
Germantown Tennessee, 38138, United States More Info
Jason Chandler, Site 0223
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901-683-0055
University of Texas MD Anderson Cancer Center
Houston Texas, 77030, United States More Info
Robert Orlowski, Site 0275
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713-304-7746
Mays Cancer Center
San Antonio Texas, 78229, United States More Info
Matthew Butler, Site 0267
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210-450-1818
Utah Cancer Specialists
Salt Lake City Utah, 84106, United States More Info
Stephan Kendall, Site 0207
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801-462-1053
Hematology Oncology Associates of Fredericksburg
Fredericksburg Virginia, 22408, United States More Info
Christopher Vaughn, Site 0297
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540-371-0079
VA Puget Sound Health Care System
Seattle Washington, 98108, United States More Info
Nicholas Burwick, Site 0268
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206-764-2036
Fred Hutchinson Cancer Center
Seattle Washington, 98109, United States
Local Institution
Spokane Washington, 99208, United States More Info
Site 0097
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University of Wisconsin Hospitals and Clinics
Madison Wisconsin, 53792, United States
Local Institution - 0318
Chivilcoy Buenos Aires, 6620, Argentina More Info
Site 0318
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Local Institution - 0249
Cordoba Córdoba, 5016, Argentina More Info
Site 0249
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Local Institution - 0239
Viedma Río Negro, R8500, Argentina More Info
Site 0239
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Local Institution - 0200
Rosario Santa Fe, 2000, Argentina More Info
Site 0200
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Local Institution - 0213
Buenos Aires , 1425, Argentina More Info
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Local Institution
Buenos Aires , C1431, Argentina More Info
Site 0162
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Local Institution - 0214
Buenos Aires , CP128, Argentina More Info
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Local Institution - 0248
Santa Fe , 3000, Argentina More Info
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Local Institution - 0055
Liverpool New South Wales, 2170, Australia More Info
Site 0055
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Local Institution - 0017
Nowra New South Wales, 2541, Australia More Info
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Local Institution - 0004
Waratah New South Wales, 2298, Australia More Info
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Local Institution - 0221
Box Hill Victoria, 3128, Australia More Info
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Local Institution - 0003
Melbourne Victoria, 3004, Australia More Info
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Local Institution - 0002
Melbourne Victoria, 3065, Australia More Info
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Local Institution - 0040
Nedlands Western Australia, 6009, Australia More Info
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Local Institution
Krems an der Donau , 3500, Austria More Info
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Leoben , 8700, Austria More Info
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Local Institution
Linz , 4020, Austria More Info
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Local Institution
St. Pölten , 3100, Austria More Info
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Local Institution
Wels , 4600, Austria More Info
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Local Institution - 0206
Gent Oost-Vlaanderen, 9000, Belgium More Info
Site 0206
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Local Institution - 0314
Joinville Santa Catarina, 89202, Brazil More Info
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Local Institution - 0305
Jaú São Paulo, 17210, Brazil More Info
Site 0305
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Local Institution - 0225
Greenfield Park Quebec, J4V 2, Canada More Info
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Local Institution - 0174
Montreal Quebec, H4J 1, Canada More Info
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Local Institution - 0222
Quebec City Quebec, G1J 1, Canada More Info
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Local Institution - 0062
Beijing City Beijing, 10004, China More Info
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Local Institution - 0237
Xiamen Fujian, 36100, China More Info
Site 0237
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Local Institution - 0238
Shenzhen Guangdong, 51803, China More Info
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Local Institution - 0240
Nanning Guangxi, 53000, China More Info
Site 0240
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Local Institution - 0111
Nanjing Jiangsu, 21000, China More Info
Site 0111
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Local Institution - 0287
Shenyang Liaoning, 11000, China More Info
Site 0287
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Local Institution - 0202
Kunming Yunnan, 65003, China More Info
Site 0202
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Local Institution - 0254
Shijiazhuang , 05003, China More Info
Site 0254
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Local Institution - 0256
Kuopio Pohjois-Savo, 70210, Finland More Info
Site 0256
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Institut de cancérologie Strasbourg Europe (ICANS)
Strasbourg Alsace, 67033, France More Info
Cécile SONNTAG, Site 0175
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0615175400
CHU Bordeaux Haut-Leveque
Pessac Aquitaine, 33600, France More Info
Cyrille Hulin, Site 0091
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33557656511
Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carémeau
Nîmes Gard, 30029, France More Info
Elodie SCHERMAN, Site 0216
Contact
0662455526
Hopital Claude Huriez - CHU de Lille
Lille Nord, 59000, France More Info
Salomon Manier, Site 0146
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33320444292
Centre Leon Berard
Lyon Rhône-Alpes, 69373, France More Info
Philippe REY, Site 0205
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+334 26 55 68 02
Centre Hospitalier Universitaire Estaing
Clermont-Ferrand , 63100, France More Info
Anne Pascale Grandjean, Site 0116
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07 51 63 68 02
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
Limoges , 87042, France More Info
Murielle Roussel, Site 0167
Contact
+33531155050
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
Nantes , 44093, France More Info
Cyrille Touzeau, Site 0043
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33240083271
Local Institution
Rennes Cedex 02 , 35023, France More Info
Site 0057
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Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
Tours , 37032, France More Info
Thomas Chalopin, Site 0188
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0643879861
Hôpital Saint Antoine
Paris ÃŽle-de-France, 75571, France More Info
Mohamad Mohty, Site 0115
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33149282620
Local Institution
Bonn , 53127, Germany More Info
Site 0092
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Local Institution
Kiel , 24105, Germany More Info
Site 0058
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Local Institution
Marburg , 35043, Germany More Info
Site 0059
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Local Institution
Tuebingen , 72076, Germany More Info
Site 0010
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Local Institution
Tuebingen , 72076, Germany More Info
Site 0015
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Azienda Ospedaliera Sant'Andrea
Rome Roma, 00189, Italy More Info
Agostino Tafuri, Site 0212
Contact
06337715113
Policlinico "G. Rodolico"
Catania Sicilia, 95123, Italy More Info
Francesco Di Raimondo, Site 0160
Contact
+39-0953781956
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna , 40138, Italy More Info
Michele Cavo, Site 0159
Contact
390516363680
Fondazione IRCCS Policlinico San Matteo
Pavia , 27100, Italy More Info
silvia mangiacavalli, Site 0158
Contact
00393476193363
Local Institution - 0281
Kashiwa Chiba, 277-8, Japan More Info
Site 0281
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Local Institution - 0278
Kitakyushu-shi Fukuoka, 806-8, Japan More Info
Site 0278
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Local Institution - 0280
Sapporo Hokkaido, 003-0, Japan More Info
Site 0280
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Local Institution - 0279
Chiba , 260-8, Japan More Info
Site 0279
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Local Institution - 0286
Fukuoka , 810-8, Japan More Info
Site 0286
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Local Institution - 0291
Hiroshima , 730-0, Japan More Info
Site 0291
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Local Institution - 0284
Kumamoto , 860-8, Japan More Info
Site 0284
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Local Institution - 0300
Tokyo , 105-8, Japan More Info
Site 0300
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Local Institution - 0283
Tokyo , 150-8, Japan More Info
Site 0283
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Local Institution - 0258
Seoul Seoul-teukbyeolsi [Seoul], 05505, Korea, Republic of More Info
Site 0258
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Local Institution
Busan , 49241, Korea, Republic of More Info
Site 0087
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Local Institution
Hwasun , , Korea, Republic of More Info
Site 0085
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Local Institution
Seongnam , 13620, Korea, Republic of More Info
Site 0102
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Local Institution
Seongnam , 13620, Korea, Republic of More Info
Site 0086
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Local Institution
Seoul , 03080, Korea, Republic of More Info
Site 0101
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Local Institution
Seoul , 03080, Korea, Republic of More Info
Site 0081
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Local Institution
Seoul , 03722, Korea, Republic of More Info
Site 0100
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Local Institution
Seoul , 03722, Korea, Republic of More Info
Site 0090
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Local Institution
Seoul , 06351, Korea, Republic of More Info
Site 0083
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Local Institution
Seoul , 138-7, Korea, Republic of More Info
Site 0082
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Local Institution
Seoul , , Korea, Republic of More Info
Site 0104
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Local Institution
Seoul , , Korea, Republic of More Info
Site 0084
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Local Institution - 0224
Torun Kujawsko-pomorskie, 87-10, Poland More Info
Site 0224
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Local Institution - 0219
Warsaw Mazowieckie, 02-77, Poland
Local Institution - 0250
Warsaw Mazowieckie, 02-77, Poland More Info
Site 0250
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Local Institution - 0292
SÅ‚upsk Pomorskie, 76-20, Poland More Info
Site 0292
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Local Institution
Chorzów , 41-50, Poland More Info
Site 0185
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Local Institution
Gdansk , 80214, Poland More Info
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Lublin , 20-60, Poland More Info
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Wroclaw , 50-36, Poland More Info
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Local Institution - 0301
Porto , 4200-, Portugal More Info
Site 0301
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Local Institution - 0252
Palma Balears [Baleares], 07120, Spain More Info
Site 0252
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Local Institution - 0073
Barcelona Catalunya [Cataluña], 08036, Spain
Local Institution - 0210
Barcelona Catalunya [Cataluña], 08036, Spain More Info
Site 0210
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Local Institution - 0253
Marbella Málaga, 29603, Spain More Info
Site 0253
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Local Institution - 0232
Ankara , 0, Turkey More Info
Site 0232
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Local Institution - 0228
Istanbul , 34093, Turkey More Info
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Local Institution - 0229
Ä°zmir , 35100, Turkey More Info
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Local Institution - 0226
Kayseri , 0, Turkey More Info
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Local Institution - 0227
Samsun , 55139, Turkey More Info
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Local Institution - 0218
Truro England, TR1 3, United Kingdom More Info
Site 0218
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Local Institution - 0304
Barnet , EN5 3, United Kingdom More Info
Site 0304
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Local Institution - 0217
Stoke-on-Trent , ST4 6, United Kingdom More Info
Site 0217
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How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 3

Estimated Enrollment:

760

Study ID:

NCT05519085

Recruitment Status:

Recruiting

Sponsor:


Bristol-Myers Squibb

How clear is this clinincal trial information?

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