A Study to Evaluate CC-92480, Bortezomib and Dexamethasone (480Vd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) Summary The purpose of this study is to compare the efficacy and safety of CC-92480, bortezomib and dexamethasone (480Vd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapse d or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.
View Eligibility Criteria Eligibility Criteria Inclusion Criteria: Participant has documented diagnosis of MM and measurable disease, defined as any of the following: M-protein ≥ 0.5 grams per deciliter (g/dL) by serum protein electrophoresis (sPEP) or M-protein ≥ 200 milligrams (mg) per 24-hour urine collection by urine protein electrophoresis (uPEP) For participants without measurable disease in sPEP or uPEP: serum free light chain (sFLC) levels > 100 mg/L (10 mg/dL) involved light chain and an abnormal kappa/lambda FLC ratio. Participants received 1 to 3 prior lines of antimyeloma therapy. Participants achieved minimal response [MR] or better to at least 1 prior antimyeloma therapy. Exclusion Criteria: Participant has had progression during treatment or within 60 days of the last dose of a proteasome inhibitor. For participants with prior treatment of a bortezomib containing regimen, the best response achieved was not a minimal response (MR) or better, or participant discontinued bortezomib due to toxicity. Participant has had prior treatment with CC-92480 or pomalidomide. Other protocol-defined criteria apply.
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There are 120 Locations for this study
Local Institution Fayetteville Arkansas, 72703, United States
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Sharp Memorial Hospital San Diego California, 92123, United States
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Private Practice - Dr. James R. Berenson West Hollywood California, 90069, United States
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Yale University School of Medicine New Haven Connecticut, 06510, United States
Advanced Research Tamarac Florida, 33321, United States
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University Cancer & Blood Center, LLC Athens Georgia, 30607, United States
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Local Institution Marietta Georgia, 30060, United States
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University of Iowa Iowa City Iowa, 52242, United States
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Tulane Cancer Center New Orleans Louisiana, 70112, United States
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Dana-Farber Cancer Institute Boston Massachusetts, 02215, United States
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University of Michigan Ann Arbor Michigan, 48109, United States
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Hattiesburg Clinic Hematology/Oncology Hattiesburg Mississippi, 39401, United States
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The University of Mississippi Medical Center Jackson Mississippi, 39213, United States
Mercy Research - David C. Pratt Cancer Center Saint Louis Missouri, 63141, United States
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Astera Cancer Care East Brunswick New Jersey, 08816, United States
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University of New Mexico Comprehensive Cancer Center Albuquerque New Mexico, 87131, United States
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Erie County Medical Center Buffalo New York, 14215, United States
R.J. Zuckerberg Cancer Center Lake Success New York, 11042, United States
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Great Lakes Cancer Care Williamsville New York, 14221, United States
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Duke Cancer Institute Durham North Carolina, 27710, United States
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Cleveland Clinic Cleveland Ohio, 44195, United States
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AHN West Penn Hospital Pittsburgh Pennsylvania, 15224, United States
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WellSpan Oncology Research York Pennsylvania, 17403, United States
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The West Clinic, PLLC dba West Cancer Center Germantown Tennessee, 38138, United States
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University of Texas MD Anderson Cancer Center Houston Texas, 77030, United States
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Mays Cancer Center San Antonio Texas, 78229, United States
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Utah Cancer Specialists Salt Lake City Utah, 84106, United States
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Hematology Oncology Associates of Fredericksburg Fredericksburg Virginia, 22408, United States
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VA Puget Sound Health Care System Seattle Washington, 98108, United States
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Fred Hutchinson Cancer Center Seattle Washington, 98109, United States
Local Institution Spokane Washington, 99208, United States
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University of Wisconsin Hospitals and Clinics Madison Wisconsin, 53792, United States
Local Institution - 0318 Chivilcoy Buenos Aires, 6620, Argentina
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Local Institution - 0249 Cordoba Córdoba, 5016, Argentina
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Local Institution - 0239 Viedma RÃo Negro, R8500, Argentina
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Local Institution - 0200 Rosario Santa Fe, 2000, Argentina
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Local Institution - 0213 Buenos Aires , 1425, Argentina
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Local Institution Buenos Aires , C1431, Argentina
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Local Institution - 0214 Buenos Aires , CP128, Argentina
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Local Institution - 0248 Santa Fe , 3000, Argentina
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Local Institution - 0055 Liverpool New South Wales, 2170, Australia
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Local Institution - 0017 Nowra New South Wales, 2541, Australia
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Local Institution - 0004 Waratah New South Wales, 2298, Australia
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Local Institution - 0221 Box Hill Victoria, 3128, Australia
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Local Institution - 0003 Melbourne Victoria, 3004, Australia
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Local Institution - 0002 Melbourne Victoria, 3065, Australia
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Local Institution - 0040 Nedlands Western Australia, 6009, Australia
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Local Institution Krems an der Donau , 3500, Austria
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Local Institution Leoben , 8700, Austria
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Local Institution Linz , 4020, Austria
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Local Institution St. Pölten , 3100, Austria
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Local Institution Wels , 4600, Austria
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Local Institution - 0206 Gent Oost-Vlaanderen, 9000, Belgium
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Local Institution - 0314 Joinville Santa Catarina, 89202, Brazil
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Local Institution - 0305 Jaú São Paulo, 17210, Brazil
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Local Institution - 0225 Greenfield Park Quebec, J4V 2, Canada
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Local Institution - 0174 Montreal Quebec, H4J 1, Canada
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Local Institution - 0222 Quebec City Quebec, G1J 1, Canada
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Local Institution - 0062 Beijing City Beijing, 10004, China
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Local Institution - 0237 Xiamen Fujian, 36100, China
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Local Institution - 0238 Shenzhen Guangdong, 51803, China
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Local Institution - 0240 Nanning Guangxi, 53000, China
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Local Institution - 0111 Nanjing Jiangsu, 21000, China
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Local Institution - 0287 Shenyang Liaoning, 11000, China
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Local Institution - 0202 Kunming Yunnan, 65003, China
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Local Institution - 0254 Shijiazhuang , 05003, China
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Local Institution - 0256 Kuopio Pohjois-Savo, 70210, Finland
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Institut de cancérologie Strasbourg Europe (ICANS) Strasbourg Alsace, 67033, France
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CHU Bordeaux Haut-Leveque Pessac Aquitaine, 33600, France
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Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carémeau Nîmes Gard, 30029, France
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Hopital Claude Huriez - CHU de Lille Lille Nord, 59000, France
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Centre Leon Berard Lyon Rhône-Alpes, 69373, France
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Centre Hospitalier Universitaire Estaing Clermont-Ferrand , 63100, France
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Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren Limoges , 87042, France
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Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu Nantes , 44093, France
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Local Institution Rennes Cedex 02 , 35023, France
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Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau Tours , 37032, France
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Hôpital Saint Antoine Paris Île-de-France, 75571, France
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Local Institution Bonn , 53127, Germany
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Local Institution Kiel , 24105, Germany
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Local Institution Marburg , 35043, Germany
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Local Institution Tuebingen , 72076, Germany
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Local Institution Tuebingen , 72076, Germany
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Azienda Ospedaliera Sant'Andrea Rome Roma, 00189, Italy
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Policlinico "G. Rodolico" Catania Sicilia, 95123, Italy
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IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola Bologna , 40138, Italy
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Fondazione IRCCS Policlinico San Matteo Pavia , 27100, Italy
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Local Institution - 0281 Kashiwa Chiba, 277-8, Japan
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Local Institution - 0278 Kitakyushu-shi Fukuoka, 806-8, Japan
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Local Institution - 0280 Sapporo Hokkaido, 003-0, Japan
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Local Institution - 0279 Chiba , 260-8, Japan
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Local Institution - 0286 Fukuoka , 810-8, Japan
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Local Institution - 0291 Hiroshima , 730-0, Japan
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Local Institution - 0284 Kumamoto , 860-8, Japan
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Local Institution - 0300 Tokyo , 105-8, Japan
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Local Institution - 0283 Tokyo , 150-8, Japan
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Local Institution - 0258 Seoul Seoul-teukbyeolsi [Seoul], 05505, Korea, Republic of
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Local Institution Busan , 49241, Korea, Republic of
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Local Institution Hwasun , , Korea, Republic of
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Local Institution Seongnam , 13620, Korea, Republic of
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Local Institution Seongnam , 13620, Korea, Republic of
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Local Institution Seoul , 03080, Korea, Republic of
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Local Institution Seoul , 03080, Korea, Republic of
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Local Institution Seoul , 03722, Korea, Republic of
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Local Institution Seoul , 03722, Korea, Republic of
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Local Institution Seoul , 06351, Korea, Republic of
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Local Institution Seoul , 138-7, Korea, Republic of
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Local Institution Seoul , , Korea, Republic of
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Local Institution Seoul , , Korea, Republic of
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Local Institution - 0224 Torun Kujawsko-pomorskie, 87-10, Poland
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Local Institution - 0219 Warsaw Mazowieckie, 02-77, Poland
Local Institution - 0250 Warsaw Mazowieckie, 02-77, Poland
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Local Institution - 0292 Słupsk Pomorskie, 76-20, Poland
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Local Institution Chorzów , 41-50, Poland
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Local Institution Gdansk , 80214, Poland
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Local Institution Lublin , 20-60, Poland
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Local Institution Wroclaw , 50-36, Poland
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Local Institution - 0301 Porto , 4200-, Portugal
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Local Institution - 0252 Palma Balears [Baleares], 07120, Spain
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Local Institution - 0073 Barcelona Catalunya [Cataluña], 08036, Spain
Local Institution - 0210 Barcelona Catalunya [Cataluña], 08036, Spain
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Local Institution - 0253 Marbella Málaga, 29603, Spain
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Local Institution - 0232 Ankara , 0, Turkey
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Local Institution - 0228 Istanbul , 34093, Turkey
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Local Institution - 0229 İzmir , 35100, Turkey
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Local Institution - 0226 Kayseri , 0, Turkey
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Local Institution - 0227 Samsun , 55139, Turkey
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Local Institution - 0218 Truro England, TR1 3, United Kingdom
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Local Institution - 0304 Barnet , EN5 3, United Kingdom
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Local Institution - 0217 Stoke-on-Trent , ST4 6, United Kingdom
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