Multiple Myeloma Clinical Trial

A Study to Evaluate Efficacy and Safety of Alnuctamab Compared to Standard of Care Regimens in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Summary

The purpose of this study is to evaluate the efficacy and safety of alnuctamab compared to standard of care regimens in participants with relapsed or refractory multiple myeloma (RRMM).

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria

Participant is willing and able to adhere to the study visit schedule and other protocol requirements including bone marrow aspirations and/or biopsies and hospitalization during the first cycle.

Documented diagnosis of multiple myeloma (MM), and must:.

i) Received at least 1 but not more than 3 prior lines of anti-myeloma therapy.

ii) Received prior treatment with lenalidomide and an anti-CD38 monoclonal antibody (for at least 2 consecutive cycles).

iii) Achieved minimal response (MR) or better to at least 1 prior anti-myeloma therapy.

iv) Documented PD during or after their last anti-myeloma therapy or failure to achieve response.

Must have measurable disease (as determined by central laboratory).
Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0, 1, or 2 at the time of the screening.

Exclusion Criteria

Active, uncontrolled, or suspected infection.
Known current, or history of, central nervous system involvement of multiple myeloma.
History or presence of clinically relevant CNS pathology.
Received prior BCMA-targeted TCE or BCMA-targeted CAR-T therapy.
Previously received allogeneic stem cell transplantation at any time or received autologous stem cell transplantation within 3 months of initiating study intervention.
Other protocol-defined Inclusion/Exclusion criteria apply.

Study is for people with:

Multiple Myeloma

Phase:

Phase 3

Estimated Enrollment:

466

Study ID:

NCT06232707

Recruitment Status:

Not yet recruiting

Sponsor:

Celgene

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There are 163 Locations for this study

See Locations Near You

Local Institution - 0151
Birmingham Alabama, 35294, United States More Info
Site 0151
Contact
Local Institution - 0088
Los Angeles California, 90095, United States More Info
Site 0088
Contact
Local Institution - 0358
Stanford California, 94305, United States More Info
Site 0358
Contact
Local Institution - 0355
New Haven Connecticut, 06520, United States More Info
Site 0355
Contact
Local Institution - 0434
Washington District of Columbia, 20007, United States More Info
Site 0434
Contact
Local Institution - 0323
New Orleans Louisiana, 70112, United States More Info
Site 0323
Contact
Local Institution - 0324
Baltimore Maryland, 21218, United States More Info
Site 0324
Contact
Local Institution - 0435
Billings Montana, 59102, United States More Info
Site 0435
Contact
Local Institution - 0157
Hackensack New Jersey, 07601, United States More Info
Site 0157
Contact
Local Institution - 0359
Summit New Jersey, 07901, United States More Info
Site 0359
Contact
Local Institution - 0430
Lake Success New York, 11042, United States More Info
Site 0430
Contact
Local Institution - 0396
New York New York, 10065, United States More Info
Site 0396
Contact
Local Institution - 0306
Cincinnati Ohio, 45220, United States More Info
Site 0306
Contact
Local Institution - 0199
Cleveland Ohio, 44109, United States More Info
Site 0199
Contact
Local Institution - 0437
Pittsburgh Pennsylvania, 15224, United States More Info
Site 0437
Contact
Local Institution - 0352
Providence Rhode Island, 02903, United States More Info
Site 0352
Contact
Local Institution - 0420
Watertown South Dakota, 57201, United States More Info
Site 0420
Contact
Local Institution - 0168
Dallas Texas, 75390, United States More Info
Site 0168
Contact
Local Institution - 0405
Seattle Washington, 98109, United States More Info
Site 0405
Contact
Local Institution - 0222
Florencio Varela Buenos Aires, 1888, Argentina More Info
Site 0222
Contact
Local Institution - 0001
La Plata Buenos Aires, 1900, Argentina More Info
Site 0001
Contact
Local Institution - 0262
Pilar Buenos Aires, 1629, Argentina More Info
Site 0262
Contact
Local Institution - 0002
Buenos Aires Ciudad Autónoma De Buenos Aires, C1118, Argentina More Info
Site 0002
Contact
Local Institution - 0260
Liverpool New South Wales, 2170, Australia More Info
Site 0260
Contact
Local Institution - 0246
Macquarie University New South Wales, 2109, Australia More Info
Site 0246
Contact
Local Institution - 0022
Waratah New South Wales, 2298, Australia More Info
Site 0022
Contact
Local Institution - 0397
Brisbane Queensland, 4120, Australia More Info
Site 0397
Contact
Local Institution - 0021
Box Hill Victoria, 3128, Australia More Info
Site 0021
Contact
Local Institution - 0019
Clayton Victoria, 3168, Australia More Info
Site 0019
Contact
Local Institution - 0018
Melbourne Victoria, 3004, Australia More Info
Site 0018
Contact
Local Institution - 0003
Melbourne Victoria, 3065, Australia More Info
Site 0003
Contact
Local Institution - 0333
St. Polten Niederösterreich, 3100, Austria More Info
Site 0333
Contact
Local Institution - 0337
Innsbruck Tirol, 6020, Austria More Info
Site 0337
Contact
Local Institution - 0334
Salzburg , 5020, Austria More Info
Site 0334
Contact
Local Institution - 0332
Wien , 1090, Austria More Info
Site 0332
Contact
Local Institution - 0284
Brasschaat Antwerpen, 2930, Belgium More Info
Site 0284
Contact
Local Institution - 0280
Verviers Liège, 4800, Belgium More Info
Site 0280
Contact
Local Institution - 0279
Yvoir Namur, 5530, Belgium More Info
Site 0279
Contact
Local Institution - 0286
Leuven Vlaams-Brabant, 3000, Belgium More Info
Site 0286
Contact
Local Institution - 0274
Belo Horizonte Minas Gerais, 30110, Brazil More Info
Site 0274
Contact
Local Institution - 0351
Natal Rio Grande Do Norte, 59025, Brazil More Info
Site 0351
Contact
Local Institution - 0369
Sao Paulo São Paulo, 01509, Brazil More Info
Site 0369
Contact
Local Institution - 0291
Rio de Janeiro , 22250, Brazil More Info
Site 0291
Contact
Local Institution - 0211
São Paulo , 05652, Brazil More Info
Site 0211
Contact
Local Institution - 0417
Calgary Alberta, T2N 4, Canada More Info
Site 0417
Contact
Local Institution - 0423
Edmonton Alberta, T6G1Z, Canada More Info
Site 0423
Contact
Local Institution - 0402
London Ontario, N6A 5, Canada More Info
Site 0402
Contact
Local Institution - 0395
Toronto Ontario, M5G 2, Canada More Info
Site 0395
Contact
Local Institution - 0031
Montreal Quebec, H1T 2, Canada More Info
Site 0031
Contact
Local Institution - 0098
Montréal Quebec, H2X 1, Canada More Info
Site 0098
Contact
Local Institution - 0027
Santiago Metropolitana DE Santiago, 75802, Chile More Info
Site 0027
Contact
Local Institution - 0030
Santiago Región Metropolitana De Santiago, 75009, Chile More Info
Site 0030
Contact
Local Institution - 0026
Santiago Región Metropolitana De Santiago, 76200, Chile More Info
Site 0026
Contact
Local Institution - 0029
Santiago Región Metropolitana De Santiago, 76505, Chile More Info
Site 0029
Contact
Local Institution - 0413
Beijing Beijing, 0, China More Info
Site 0413
Contact
Local Institution - 0230
Beijing Beijing, 10002, China More Info
Site 0230
Contact
Local Institution - 0040
Beijing Beijing, 10003, China More Info
Site 0040
Contact
Local Institution - 0366
Changping Beijing, 10220, China More Info
Site 0366
Contact
Local Institution - 0057
Chongqing Chongqing, 40001, China More Info
Site 0057
Contact
Local Institution - 0066
Guangzhou Guangdong, 51006, China More Info
Site 0066
Contact
Local Institution - 0080
Guangzhou Guangdong, 51012, China More Info
Site 0080
Contact
Local Institution - 0226
Guangzhou Guangdong, 51051, China More Info
Site 0226
Contact
Local Institution - 0368
Shenzhen Guangdong, 51803, China More Info
Site 0368
Contact
Local Institution - 0365
Baoding Hebei, 07103, China More Info
Site 0365
Contact
Local Institution - 0082
Shijiazhuang Hebei, 05005, China More Info
Site 0082
Contact
Local Institution - 0041
Zhengzhou Henan, 45000, China More Info
Site 0041
Contact
Local Institution - 0075
Wuhan Hubei, 43003, China More Info
Site 0075
Contact
Local Institution - 0062
Changsha Hunan, 41001, China More Info
Site 0062
Contact
Local Institution - 0053
Changsha Hunan, 41001, China More Info
Site 0053
Contact
Local Institution - 0055
Nanjing Jiangsu, 21000, China More Info
Site 0055
Contact
Local Institution - 0067
Suzhou Jiangsu, 21500, China More Info
Site 0067
Contact
Local Institution - 0377
Xuzhou Jiangsu, 22100, China More Info
Site 0377
Contact
Local Institution - 0044
Shenyang Liaoning, 11000, China More Info
Site 0044
Contact
Local Institution - 0072
Xi'An Shaanxi, 71000, China More Info
Site 0072
Contact
Local Institution - 0077
Jinan Shandong, 25001, China More Info
Site 0077
Contact
Local Institution - 0083
Jinan Shandong, 25011, China More Info
Site 0083
Contact
Local Institution - 0273
Shanghai Shanghai, 20003, China More Info
Site 0273
Contact
Local Institution - 0421
Shanghai Shanghai, 20008, China More Info
Site 0421
Contact
Local Institution - 0245
Taiyuan Shanxi, 03000, China More Info
Site 0245
Contact
Local Institution - 0056
Tianjin Tianjin, 30005, China More Info
Site 0056
Contact
Local Institution - 0422
Tianjin Tianjin, 30030, China More Info
Site 0422
Contact
Local Institution - 0070
Hangzhou Zhejiang, 31000, China More Info
Site 0070
Contact
Local Institution - 0203
Hangzhou Zhejiang, 31000, China More Info
Site 0203
Contact
Local Institution - 0367
Qingdao , 26601, China More Info
Site 0367
Contact
Local Institution - 0013
Brno Brno-město, 625 0, Czechia More Info
Site 0013
Contact
Local Institution - 0247
Olomouc Olomoucký Kraj, 779 0, Czechia More Info
Site 0247
Contact
Local Institution - 0012
Praha 2 , 12808, Czechia More Info
Site 0012
Contact
Local Institution - 0118
Toulouse Haute-Garonne, 31100, France More Info
Site 0118
Contact
Local Institution - 0225
Montpellier Languedoc-Roussillon, 34295, France More Info
Site 0225
Contact
Local Institution - 0224
Vandoeuvre lès Nancy Lorraine, 54511, France More Info
Site 0224
Contact
Local Institution - 0084
Lille Nord, 59000, France More Info
Site 0084
Contact
Local Institution - 0085
Nantes Pays-de-la-Loire, 44000, France More Info
Site 0085
Contact
Local Institution - 0192
Pierre-Bénite Rhône, 69310, France More Info
Site 0192
Contact
Local Institution - 0331
Heidelberg Baden-Württemberg, 69120, Germany More Info
Site 0331
Contact
Local Institution - 0330
Tübingen Baden-Württemberg, 72076, Germany More Info
Site 0330
Contact
Local Institution - 0335
Dresden Sachsen, 01307, Germany More Info
Site 0335
Contact
Local Institution - 0329
Leipzig Sachsen, 04103, Germany More Info
Site 0329
Contact
Local Institution - 0339
Hamburg , 22763, Germany More Info
Site 0339
Contact
Local Institution - 0004
Athens Attikí, 115 2, Greece More Info
Site 0004
Contact
Local Institution - 0136
Chaidari Attikí, 12462, Greece More Info
Site 0136
Contact
Local Institution - 0103
Nyiregyhaza Szabolcs-Szatmár-Bereg, 4400, Hungary More Info
Site 0103
Contact
Local Institution - 0108
Szombathely Vas, 9700, Hungary More Info
Site 0108
Contact
Local Institution - 0104
Budapest , 1088, Hungary More Info
Site 0104
Contact
Local Institution - 0105
Budapest , 1097, Hungary More Info
Site 0105
Contact
Local Institution - 0370
Visakhapatnam Andhra Pradesh, 53004, India More Info
Site 0370
Contact
Local Institution - 0362
Gurugram Haryana, 12201, India More Info
Site 0362
Contact
Local Institution - 0403
Bangalore Karnataka, 56009, India More Info
Site 0403
Contact
Local Institution - 0399
Lucknow Uttar Pradesh, 22601, India More Info
Site 0399
Contact
Local Institution - 0398
Kolkata West Bengal, 70009, India More Info
Site 0398
Contact
Local Institution - 0281
Cork , T12 E, Ireland More Info
Site 0281
Contact
Local Institution - 0371
Dublin , D04 N, Ireland More Info
Site 0371
Contact
Local Institution - 0285
Dublin , D08 E, Ireland More Info
Site 0285
Contact
Local Institution - 0269
Limerick , V94 F, Ireland More Info
Site 0269
Contact
Local Institution - 0096
Meldola Emilia-Romagna, 47014, Italy More Info
Site 0096
Contact
Local Institution - 0294
Legnano Milano, 20025, Italy More Info
Site 0294
Contact
Local Institution - 0265
Milan Milano, 20162, Italy More Info
Site 0265
Contact
Local Institution - 0410
Palermo Sicilia, 90127, Italy More Info
Site 0410
Contact
Local Institution - 0409
Anjo Aichi, 446-8, Japan More Info
Site 0409
Contact
Local Institution - 0387
Nagoya Aichi, 467-8, Japan More Info
Site 0387
Contact
Local Institution - 0407
Kamogawa Chiba, 296-0, Japan More Info
Site 0407
Contact
Local Institution - 0385
Kashiwa Chiba, 277-8, Japan More Info
Site 0385
Contact
Local Institution - 0386
Isehara Kanagawa, 259-1, Japan More Info
Site 0386
Contact
Local Institution - 0390
Osaka-sayama Osaka, 589-8, Japan More Info
Site 0390
Contact
Local Institution - 0381
Shimotsuga Tochigi, 321-0, Japan More Info
Site 0381
Contact
Local Institution - 0382
Koto Tokyo, 135-8, Japan More Info
Site 0382
Contact
Local Institution - 0383
Chiba , 260-8, Japan More Info
Site 0383
Contact
Local Institution - 0391
Kumamoto , 860-8, Japan More Info
Site 0391
Contact
Local Institution - 0389
Kyoto , 602-8, Japan More Info
Site 0389
Contact
Local Institution - 0388
Okayama , 701-1, Japan More Info
Site 0388
Contact
Local Institution - 0384
Tokyo , 150-8, Japan More Info
Site 0384
Contact
Local Institution - 0240
Seongnam Kyǒnggi-do, 13620, Korea, Republic of More Info
Site 0240
Contact
Local Institution - 0221
Busan Pusan-Kwangyǒkshi, 49201, Korea, Republic of More Info
Site 0221
Contact
Local Institution - 0036
Seoul Seoul-teukbyeolsi [Seoul], 03080, Korea, Republic of More Info
Site 0036
Contact
Local Institution - 0239
Seoul Seoul-teukbyeolsi [Seoul], 05505, Korea, Republic of More Info
Site 0239
Contact
Local Institution - 0034
Seoul Seoul-teukbyeolsi [Seoul], 06351, Korea, Republic of More Info
Site 0034
Contact
Local Institution - 0035
Seoul Seoul-teukbyeolsi [Seoul], 06591, Korea, Republic of More Info
Site 0035
Contact
Local Institution - 0137
Løenskog Akershus, 1474, Norway More Info
Site 0137
Contact
Local Institution - 0115
Bergen Hordaland, 5021, Norway More Info
Site 0115
Contact
Local Institution - 0193
Oslo , 0450, Norway More Info
Site 0193
Contact
Local Institution - 0242
Lisbon Lisboa, 1099-, Portugal More Info
Site 0242
Contact
Local Institution - 0415
Lisbon Lisboa, 1649-, Portugal More Info
Site 0415
Contact
Local Institution - 0255
Lisboa , 1500-, Portugal More Info
Site 0255
Contact
Local Institution - 0169
Bucuresti București, 02232, Romania More Info
Site 0169
Contact
Local Institution - 0171
Brasov , 50005, Romania More Info
Site 0171
Contact
Local Institution - 0414
București , 05009, Romania More Info
Site 0414
Contact
Local Institution - 0011
Badalona Barcelona [Barcelona], 08916, Spain More Info
Site 0011
Contact
Local Institution - 0234
El Palmar, Murcia Murcia, Región De, 30120, Spain More Info
Site 0234
Contact
Local Institution - 0008
Pamplona Navarra, 31008, Spain More Info
Site 0008
Contact
Local Institution - 0202
Jerez de la Frontera , 11407, Spain More Info
Site 0202
Contact
Local Institution - 0006
Salamanca , 37007, Spain More Info
Site 0006
Contact
Local Institution - 0007
Santiago de Compostela , 15706, Spain More Info
Site 0007
Contact
Local Institution - 0009
València , 46026, Spain More Info
Site 0009
Contact
Local Institution - 0114
Borås Västra Götalands Län [se-14], 501 8, Sweden More Info
Site 0114
Contact
Local Institution - 0111
Gothenburg Västra Götalands Län [se-14], 413 4, Sweden More Info
Site 0111
Contact
Local Institution - 0336
Bern Berne, 3010, Switzerland More Info
Site 0336
Contact
Local Institution - 0411
st.Gallen Sankt Gallen, 9007, Switzerland More Info
Site 0411
Contact
Local Institution - 0338
Zürich , 8063, Switzerland More Info
Site 0338
Contact
Local Institution - 0325
Stanbul İstanbul, 34214, Turkey More Info
Site 0325
Contact
Local Institution - 0375
Ankara , 06200, Turkey More Info
Site 0375
Contact
Local Institution - 0188
İzmir , 35100, Turkey More Info
Site 0188
Contact
Local Institution - 0187
Kayseri , 0, Turkey More Info
Site 0187
Contact
Local Institution - 0349
Southampton Hampshire, SO16 , United Kingdom More Info
Site 0349
Contact
Local Institution - 0342
London London, City Of, NW1 2, United Kingdom More Info
Site 0342
Contact
Local Institution - 0350
Cardiff , CF14 , United Kingdom More Info
Site 0350
Contact
Local Institution - 0344
Derby , DE22 , United Kingdom More Info
Site 0344
Contact
Local Institution - 0343
Manchester , M20 4, United Kingdom More Info
Site 0343
Contact

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 3

Estimated Enrollment:

466

Study ID:

NCT06232707

Recruitment Status:

Not yet recruiting

Sponsor:


Celgene

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.