Multiple Myeloma Clinical Trial

A Study to Evaluate Efficacy and Safety of Alnuctamab Compared to Standard of Care Regimens in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

Summary

The purpose of this study is to evaluate the efficacy and safety of alnuctamab compared to standard of care regimens in participants with relapsed or refractory multiple myeloma (RRMM).

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria

Participant is willing and able to adhere to the study visit schedule and other protocol requirements including bone marrow aspirations and/or biopsies and hospitalization during the first cycle.

Documented diagnosis of multiple myeloma (MM), and must:.

i) Received at least 1 but not more than 3 prior lines of anti-myeloma therapy.

ii) Received prior treatment with lenalidomide and an anti-CD38 monoclonal antibody (for at least 2 consecutive cycles).

iii) Achieved minimal response (MR) or better to at least 1 prior anti-myeloma therapy.

iv) Documented PD during or after their last anti-myeloma therapy or failure to achieve response.

Must have measurable disease (as determined by central laboratory).
Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0, 1, or 2 at the time of the screening.

Exclusion Criteria

Active, uncontrolled, or suspected infection.
Known current, or history of, central nervous system involvement of multiple myeloma.
History or presence of clinically relevant CNS pathology.
Received prior BCMA-targeted TCE or BCMA-targeted CAR-T therapy.
Previously received allogeneic stem cell transplantation at any time or received autologous stem cell transplantation within 3 months of initiating study intervention.
Other protocol-defined Inclusion/Exclusion criteria apply.

Study is for people with:

Multiple Myeloma

Phase:

Phase 3

Study ID:

NCT06232707

Recruitment Status:

Withdrawn

Sponsor:

Celgene

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There are 167 Locations for this study

See Locations Near You

Local Institution - 0151
Birmingham Alabama, 35294, United States
Local Institution - 0088
Los Angeles California, 90095, United States
Local Institution - 0358
Stanford California, 94305, United States
Local Institution - 0355
New Haven Connecticut, 06520, United States
Local Institution - 0434
Washington District of Columbia, 20007, United States
Local Institution - 0433
Wichita Kansas, 67214, United States
Local Institution - 0439
Saint Matthews Kentucky, 40207, United States
Local Institution - 0323
New Orleans Louisiana, 70112, United States
Local Institution - 0324
Baltimore Maryland, 21218, United States
Local Institution - 0441
Bethesda Maryland, 20889, United States
Local Institution - 0435
Billings Montana, 59102, United States
Local Institution - 0157
Hackensack New Jersey, 07601, United States
Local Institution - 0359
Summit New Jersey, 07901, United States
Local Institution - 0430
Lake Success New York, 11042, United States
Local Institution - 0396
New York New York, 10065, United States
Local Institution - 0306
Cincinnati Ohio, 45220, United States
Local Institution - 0199
Cleveland Ohio, 44109, United States
Local Institution - 0437
Pittsburgh Pennsylvania, 15224, United States
Local Institution - 0352
Providence Rhode Island, 02903, United States
Local Institution - 0420
Watertown South Dakota, 57201, United States
Local Institution - 0168
Dallas Texas, 75390, United States
Local Institution - 0405
Seattle Washington, 98109, United States
Local Institution - 0222
Florencio Varela Buenos Aires, 1888, Argentina
Local Institution - 0001
La Plata Buenos Aires, 1900, Argentina
Local Institution - 0262
Pilar Buenos Aires, 1629, Argentina
Local Institution - 0002
Buenos Aires Ciudad Autónoma De Buenos Aires, C1118, Argentina
Local Institution - 0260
Liverpool New South Wales, 2170, Australia
Local Institution - 0246
Macquarie University New South Wales, 2109, Australia
Local Institution - 0022
Waratah New South Wales, 2298, Australia
Local Institution - 0397
Brisbane Queensland, 4120, Australia
Local Institution - 0021
Box Hill Victoria, 3128, Australia
Local Institution - 0019
Clayton Victoria, 3168, Australia
Local Institution - 0018
Melbourne Victoria, 3004, Australia
Local Institution - 0003
Melbourne Victoria, 3065, Australia
Local Institution - 0333
St. Polten Niederösterreich, 3100, Austria
Local Institution - 0337
Innsbruck Tirol, 6020, Austria
Local Institution - 0334
Salzburg , 5020, Austria
Local Institution - 0332
Wien , 1090, Austria
Local Institution - 0284
Brasschaat Antwerpen, 2930, Belgium
Local Institution - 0280
Verviers Liège, 4800, Belgium
Local Institution - 0279
Yvoir Namur, 5530, Belgium
Local Institution - 0286
Leuven Vlaams-Brabant, 3000, Belgium
Local Institution - 0274
Belo Horizonte Minas Gerais, 30110, Brazil
Local Institution - 0351
Natal Rio Grande Do Norte, 59025, Brazil
Local Institution - 0369
Sao Paulo São Paulo, 01509, Brazil
Local Institution - 0291
Rio de Janeiro , 22250, Brazil
Local Institution - 0211
São Paulo , 05652, Brazil
Local Institution - 0417
Calgary Alberta, T2N 4, Canada
Local Institution - 0423
Edmonton Alberta, T6G1Z, Canada
Local Institution - 0402
London Ontario, N6A 5, Canada
Local Institution - 0395
Toronto Ontario, M5G 2, Canada
Local Institution - 0031
Montreal Quebec, H1T 2, Canada
Local Institution - 0098
Montréal Quebec, H2X 1, Canada
Local Institution - 0027
Santiago Metropolitana DE Santiago, 75802, Chile
Local Institution - 0030
Santiago Región Metropolitana De Santiago, 75009, Chile
Local Institution - 0026
Santiago Región Metropolitana De Santiago, 76200, Chile
Local Institution - 0029
Santiago Región Metropolitana De Santiago, 76505, Chile
Local Institution - 0413
Beijing Beijing, 0, China
Local Institution - 0230
Beijing Beijing, 10002, China
Local Institution - 0040
Beijing Beijing, 10003, China
Local Institution - 0366
Changping Beijing, 10220, China
Local Institution - 0057
Chongqing Chongqing, 40001, China
Local Institution - 0066
Guangzhou Guangdong, 51006, China
Local Institution - 0080
Guangzhou Guangdong, 51012, China
Local Institution - 0226
Guangzhou Guangdong, 51051, China
Local Institution - 0368
Shenzhen Guangdong, 51803, China
Local Institution - 0365
Baoding Hebei, 07103, China
Local Institution - 0082
Shijiazhuang Hebei, 05005, China
Local Institution - 0041
Zhengzhou Henan, 45000, China
Local Institution - 0075
Wuhan Hubei, 43003, China
Local Institution - 0062
Changsha Hunan, 41001, China
Local Institution - 0053
Changsha Hunan, 41001, China
Local Institution - 0055
Nanjing Jiangsu, 21000, China
Local Institution - 0067
Suzhou Jiangsu, 21500, China
Local Institution - 0377
Xuzhou Jiangsu, 22100, China
Local Institution - 0044
Shenyang Liaoning, 11000, China
Local Institution - 0072
Xi'An Shaanxi, 71000, China
Local Institution - 0077
Jinan Shandong, 25001, China
Local Institution - 0083
Jinan Shandong, 25011, China
Local Institution - 0273
Shanghai Shanghai, 20003, China
Local Institution - 0421
Shanghai Shanghai, 20008, China
Local Institution - 0245
Taiyuan Shanxi, 03000, China
Local Institution - 0056
Tianjin Tianjin, 30005, China
Local Institution - 0422
Tianjin Tianjin, 30030, China
Local Institution - 0070
Hangzhou Zhejiang, 31000, China
Local Institution - 0203
Hangzhou Zhejiang, 31000, China
Local Institution - 0367
Qingdao , 26601, China
Local Institution - 0013
Brno Brno-město, 625 0, Czechia
Local Institution - 0247
Olomouc Olomoucký Kraj, 779 0, Czechia
Local Institution - 0012
Praha 2 , 12808, Czechia
Local Institution - 0118
Toulouse Haute-Garonne, 31100, France
Local Institution - 0225
Montpellier Languedoc-Roussillon, 34295, France
Local Institution - 0224
Vandoeuvre lès Nancy Lorraine, 54511, France
Local Institution - 0084
Lille Nord, 59000, France
Local Institution - 0085
Nantes Pays-de-la-Loire, 44000, France
Local Institution - 0192
Pierre-Bénite Rhône, 69310, France
Local Institution - 0331
Heidelberg Baden-Württemberg, 69120, Germany
Local Institution - 0330
Tübingen Baden-Württemberg, 72076, Germany
Local Institution - 0335
Dresden Sachsen, 01307, Germany
Local Institution - 0329
Leipzig Sachsen, 04103, Germany
Local Institution - 0339
Hamburg , 22763, Germany
Local Institution - 0004
Athens Attikí, 115 2, Greece
Local Institution - 0136
Chaidari Attikí, 12462, Greece
Local Institution - 0103
Nyiregyhaza Szabolcs-Szatmár-Bereg, 4400, Hungary
Local Institution - 0108
Szombathely Vas, 9700, Hungary
Local Institution - 0104
Budapest , 1088, Hungary
Local Institution - 0105
Budapest , 1097, Hungary
Local Institution - 0370
Visakhapatnam Andhra Pradesh, 53004, India
Local Institution - 0362
Gurugram Haryana, 12201, India
Local Institution - 0403
Bangalore Karnataka, 56009, India
Local Institution - 0399
Lucknow Uttar Pradesh, 22601, India
Local Institution - 0398
Kolkata West Bengal, 70009, India
Local Institution - 0281
Cork , T12 E, Ireland
Local Institution - 0371
Dublin , D04 N, Ireland
Local Institution - 0285
Dublin , D08 E, Ireland
Local Institution - 0269
Limerick , V94 F, Ireland
Local Institution - 0096
Meldola Emilia-Romagna, 47014, Italy
Local Institution - 0294
Legnano Milano, 20025, Italy
Local Institution - 0265
Milan Milano, 20162, Italy
Local Institution - 0410
Palermo Sicilia, 90127, Italy
Local Institution - 0409
Anjo Aichi, 446-8, Japan
Local Institution - 0387
Nagoya Aichi, 467-8, Japan
Local Institution - 0407
Kamogawa Chiba, 296-0, Japan
Local Institution - 0385
Kashiwa Chiba, 277-8, Japan
Local Institution - 0386
Isehara Kanagawa, 259-1, Japan
Local Institution - 0390
Osaka-sayama Osaka, 589-8, Japan
Local Institution - 0381
Shimotsuga Tochigi, 321-0, Japan
Local Institution - 0382
Koto Tokyo, 135-8, Japan
Local Institution - 0419
Aomori , 030-8, Japan
Local Institution - 0383
Chiba , 260-8, Japan
Local Institution - 0391
Kumamoto , 860-8, Japan
Local Institution - 0389
Kyoto , 602-8, Japan
Local Institution - 0388
Okayama , 701-1, Japan
Local Institution - 0384
Tokyo , 150-8, Japan
Local Institution - 0240
Seongnam Kyǒnggi-do, 13620, Korea, Republic of
Local Institution - 0221
Busan Pusan-Kwangyǒkshi, 49201, Korea, Republic of
Local Institution - 0036
Seoul Seoul-teukbyeolsi [Seoul], 03080, Korea, Republic of
Local Institution - 0239
Seoul Seoul-teukbyeolsi [Seoul], 05505, Korea, Republic of
Local Institution - 0034
Seoul Seoul-teukbyeolsi [Seoul], 06351, Korea, Republic of
Local Institution - 0035
Seoul Seoul-teukbyeolsi [Seoul], 06591, Korea, Republic of
Local Institution - 0137
Løenskog Akershus, 1474, Norway
Local Institution - 0115
Bergen Hordaland, 5021, Norway
Local Institution - 0193
Oslo , 0450, Norway
Local Institution - 0242
Lisbon Lisboa, 1099-, Portugal
Local Institution - 0415
Lisbon Lisboa, 1649-, Portugal
Local Institution - 0255
Lisboa , 1500-, Portugal
Local Institution - 0169
Bucuresti București, 02232, Romania
Local Institution - 0171
Brasov , 50005, Romania
Local Institution - 0414
București , 05009, Romania
Local Institution - 0011
Badalona Barcelona [Barcelona], 08916, Spain
Local Institution - 0234
El Palmar, Murcia Murcia, Región De, 30120, Spain
Local Institution - 0008
Pamplona Navarra, 31008, Spain
Local Institution - 0202
Jerez de la Frontera , 11407, Spain
Local Institution - 0006
Salamanca , 37007, Spain
Local Institution - 0007
Santiago de Compostela , 15706, Spain
Local Institution - 0009
València , 46026, Spain
Local Institution - 0114
Borås Västra Götalands Län [se-14], 501 8, Sweden
Local Institution - 0111
Gothenburg Västra Götalands Län [se-14], 413 4, Sweden
Local Institution - 0336
Bern Berne, 3010, Switzerland
Local Institution - 0411
st.Gallen Sankt Gallen, 9007, Switzerland
Local Institution - 0338
Zürich , 8063, Switzerland
Local Institution - 0325
Stanbul İstanbul, 34214, Turkey
Local Institution - 0375
Ankara , 06200, Turkey
Local Institution - 0188
İzmir , 35100, Turkey
Local Institution - 0187
Kayseri , 0, Turkey
Local Institution - 0349
Southampton Hampshire, SO16 , United Kingdom
Local Institution - 0342
London London, City Of, NW1 2, United Kingdom
Local Institution - 0350
Cardiff , CF14 , United Kingdom
Local Institution - 0344
Derby , DE22 , United Kingdom
Local Institution - 0343
Manchester , M20 4, United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 3

Study ID:

NCT06232707

Recruitment Status:

Withdrawn

Sponsor:


Celgene

How clear is this clinincal trial information?

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