Multiple Myeloma Clinical Trial
A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma
The purpose of this study is to assess the safety, tolerability and preliminary effectiveness of CC-92480 (BMS-986348) in novel therapeutic combinations for the treatment of Relapsed or Refractory Multiple Myeloma (RRMM).
Relapsed or refractory multiple myeloma (MM) and must:
have documented disease progression during or after their last myeloma therapy
be refractory to, intolerant to, or not a candidate for available, established therapies known to provide clinical benefit in MM
Must have measurable disease
Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1
Agree to follow the CC-92480 Pregnancy Prevention Plan (PPP)
Known active or history of central nervous system (CNS) involvement of MM
Plasma cell leukemia; Waldenstrom's macroglobulinemia; polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome; or clinically significant light-chain amyloidosis.
Impaired cardiac function or clinically significant cardiac disease
Previous SARS-CoV-2 infection within 14 days for asymptomatic or mild symptomatic infections or 28 days for severe/critical illness prior to Cycle 1 Day 1 (C1D1)
For Part 1: received prior therapy with CC-92480
For Part 2: received prior therapy with CC-92480, tazemetostat, BMS-986158, or trametinib
Previously received allogeneic stem-cell transplant at any time or received autologous stem-cell transplant within 12 weeks of initiating study treatment
Received any of the following within 14 days prior to initiating study treatment:
Radiation therapy other than local therapy for myeloma associated bone lesions
Use of any systemic anti-myeloma drug therapy
Used any investigational agents within 28 days or 5 half-lives (whichever is shorter) prior to initiating study treatment
COVID-19 vaccine within 14 days prior to C1D1
Other protocol-defined inclusion/exclusion criteria apply
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There are 15 Locations for this study
Birmingham Alabama, 35249, United States More Info
Baltimore Maryland, 21287, United States More Info
Hackensack New Jersey, 07601, United States More Info
New York New York, 10021, United States More Info
Calgary Alberta, T2N 4, Canada More Info
Toronto Ontario, M5G 2, Canada More Info
Oslo Outside US And Canada, 0450, Norway More Info
Barcelona , 08026, Spain More Info
Madrid , 28041, Spain More Info
Santander , 39008, Spain More Info
London Greater London, NW1 2, United Kingdom More Info
Manchester Greater Manchester, M20 4, United Kingdom More Info
Leicester Leicestershire, LE1 5, United Kingdom More Info
Liverpool Merseyside, L7 8Y, United Kingdom
Oxford Oxfordshire, OX3 7, United Kingdom More Info
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