Feasibility and Safety of Functional Performance Testing in Patients Undergoing Hematopoietic Cell Transplantation

Inclusion Criteria:

Patients with MSK histologically confirmed hematologic malignancy
Scheduled for autologous or allogenic HCT at MSKCC
≥21 years old
ECOG performance status of 0 or 1
Completion of baseline CPET
Willing to comply with protocol related procedures

Exclusion Criteria:

Any of the following absolute contraindications to cardiopulmonary exercise testing

Acute myocardial Infarction (within 3-5 days of any planned study procedures)
Unstable angina
Uncontrolled arrhythmia causing symptoms or hemodynamic compromise
Recurrent syncope
Active endocarditis
Acute myocarditis or pericarditis
Symptomatic severe aortic stenosis
Uncontrolled heart failure
Acute pulmonary embolus or pulmonary infarction within 3 months of any planned study procedures
Thrombosis of lower extremities
Suspected dissecting aneurysm
Uncontrolled asthma
Pulmonary edema
Respiratory failure
Acute non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis)
Presence of any other concurrent, actively treated malignancy;
History of any other malignancy treated within the past 3 years (other than non-melanoma skin cancer);
Room air desaturation at rest ≤85%
Mental impairment leading to inability to cooperate