Multiple Myeloma Clinical Trial
Loratadine for the Reduction of G-CSF Induced Bone Pain in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization
This early phase I trial studies how well loratadine works in reducing granulocyte-colony stimulating factor (G-CSF) induced bone pain in patients with multiple myeloma who are undergoing stem cell mobilization. Loratadine is an antihistamine that may help to reduce or control bone pain during the process of stem cell collection in patients with multiple myeloma.
I. To evaluate the efficacy of the second-generation antihistamine, loratadine, as prophylaxis for filgrastim (i.e., Neupogen, Zarxio) induced bone pain during stem cell mobilization in multiple myeloma patients.
I. To examine the frequency and quantity of supportive analgesic medications needed in addition to loratadine or placebo for filgrastim induced bone pain.
II. To identify risk factors associated with developing filgrastim induced bone pain.
OUTLINE: Patients are randomized to 1 of 2 cohorts.
COHORT I: Beginning 5 days before the first dose of standard of care filgrastim, patients receive loratadine orally (PO) once daily (QD). Treatment continues until 5 days after completion of stem cell mobilization in the absence of disease progression or unacceptable toxicity.
COHORT II: Beginning 5 days before the first dose of standard of care filgrastim, patients receive placebo PO QD. Treatment continues until 5 days after completion of stem cell mobilization in the absence of disease progression or unacceptable toxicity.
Patient must be able to provide informed consent
Patients with confirmed diagnosis of multiple myeloma
Able to swallow and retain oral medication
All ethnic groups are eligible
Non-English speaking person
Patients undergoing haploidentical allogeneic hematopoietic stem cell transplant
Known allergies, hypersensitivity, or intolerance to any of the study medications, excipients, or similar compounds
Any medical complications or conditions that would, in the investigator's judgement, interfere with full participation in the study
On therapeutic dose of aspirin (doses greater than 81 mg) within 7 days prior to the start of the study
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There is 1 Location for this study
New Brunswick New Jersey, 08903, United States More Info
New Brunswick New Jersey, 08903, United States
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