Multiple Myeloma Clinical Trial

MMRF Molecular Profiling Protocol

Summary

Here we propose an "integrative sequencing approach" utilizing a 1500 gene exome comparative analysis between multiple myeloma or related plasma cell malignancies and normal cells coupled to capture transcriptome sequencing to provide a nearly comprehensive landscape of the genetic alterations for the purpose of identifying informative and/or actionable mutations in patients with multiple myeloma and plasma cell malignancies. The approach will enable the detection of point mutations, insertions/deletions, gene fusions and rearrangements, amplifications/deletions, and outlier expressed genes among other classes of alterations.

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Full Description

Here we propose an "integrative sequencing approach" utilizing a 1500 gene exome comparative analysis between multiple myeloma or related plasma cell malignancies and normal cells coupled to capture transcriptome sequencing to provide a nearly comprehensive landscape of the genetic alterations for the purpose of identifying informative and/or actionable mutations in patients with multiple myeloma and plasma cell malignancies. The approach will enable the detection of point mutations, insertions/deletions, gene fusions and rearrangements, amplifications/deletions, and outlier expressed genes among other classes of alterations.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Patients must have a diagnosis of multiple myeloma or related malignancy
Patients are undergoing standard of care bone marrow aspirates
Patients (male or female) from any race or ethnicity must be at least 18 years of age at the time of registration.
Procedure-specific signed informed consent form prior to initiation of any study-related procedures.

Exclusion Criteria:

It is the enrolling study physician's discretion to decide if a patient is not fit enough to undergo a bone marrow aspirate.
Patients who are incarcerated are not eligible to participate.
Women who are pregnant
Patients who have had another malignancy within the last five (5) years (except for basal or squamous cell carcinoma, or in situ cancer of the cervix) where there is a possibility to contaminate the bone marrow aspirate.

Study is for people with:

Multiple Myeloma

Estimated Enrollment:

1000

Study ID:

NCT02884102

Recruitment Status:

Active, not recruiting

Sponsor:

Multiple Myeloma Research Foundation

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There are 18 Locations for this study

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Mayo Clinic - Scottsdale
Scottsdale Arizona, 85259, United States
City of Hope
Duarte California, 91010, United States
UCSF Medical Center
San Francisco California, 94143, United States
Mayo Clinic - Jacksonville
Jacksonville Florida, 32224, United States
Emory University
Atlanta Georgia, 30322, United States
University of Chicago
Chicago Illinois, , United States
Massachusetts General Hospital
Boston Massachusetts, 02114, United States
Dana-Farber Cancer Institute
Boston Massachusetts, 02215, United States
University of Michigan
Ann Arbor Michigan, 48109, United States
Barbara Ann Karmanos Cancer Institute
Detroit Michigan, 48201, United States
Mayo Clinic - Rochester
Rochester Minnesota, 55905, United States
Washington University
Saint Louis Missouri, 63110, United States
Hackensack University Medical Center
Hackensack New Jersey, 07601, United States
Mount Sinai Medical Center
New York New York, 10029, United States
Levine Cancer Institute
Charlotte North Carolina, 28204, United States
Ohio State University
Columbus Ohio, 43210, United States
Sarah Cannon Research Institute
Nashville Tennessee, 37203, United States
Baylor Research Institute
Dallas Texas, 75246, United States
Virginia Cancer Specialists
Fairfax Virginia, , United States
Princess Margaret Cancer Centre
Toronto Ontario, M5G 2, Canada

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Estimated Enrollment:

1000

Study ID:

NCT02884102

Recruitment Status:

Active, not recruiting

Sponsor:


Multiple Myeloma Research Foundation

How clear is this clinincal trial information?

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