Safety and Efficacy Study of Imexon for Treatment of Multiple Myeloma Patients

Inclusion Criteria:

Advanced myeloma, with measurable disease as defined in the protocol.
Prior treatment, at least 2 prior regimens are required. This may include prior treatment with investigational products.
Able to perform the activities of daily living.
Off prior therapy for at least 2-4 weeks depending on the drug.
Blood counts and blood chemistries in or near normal range.
If female, neither pregnant nor nursing.
Willing to use contraceptives to prevent pregnancy.
No other serious illnesses.
No other active malignancy.
No serious infections.
No current other drug therapy for the myeloma except for steroid therapy under certain circumstances. Biphosphonate therapy is permitted.
Prior radiation is permitted.

Exclusion Criteria:

Use of corticosteroids for amyloid disorders, or high dose chronic steroids.