Multiple Myeloma Clinical Trial

Clinical Trial Finder Multiple Myeloma Trials

Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer

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Summary

This study will assess the safety and efficacy of LGX818 when combined with cetuximab or combined with cetuximab and BYL719 in patients with BRAF mutant metastatic colorectal cancer

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Eligibility Criteria

Inclusion Criteria:

Metastatic colorectal cancer
Progression after at least one prior standard of care regimen or be intolerant to irinotecan-based regimens
Life expectancy ≥ 3 months
ECOG performance status ≤ 2

Exclusion Criteria:

Symptomatic or untreated leptomeningeal disease
Symptomatic brain metastasis
Patients with clinically manifested diabetes
Acute or chronic pancreatitis
Clinically significant cardiac disease

Other protocol-defined inclusion/exclusion criteria may apply.

Study is for people with:

Multiple Myeloma

Phase:

Phase 2

Estimated Enrollment:

156

Study ID:

NCT01719380

Recruitment Status:

Completed

Sponsor:

Pfizer

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There are 45 Locations for this study

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Keck Hospital of USC
Los Angeles California, 90033, United States
LAC&USC Medical Center
Los Angeles California, 90033, United States
USC/Norris Comprehensive Cancer Center
Los Angeles California, 90033, United States
Ronald Reagan UCLA Medical Center
Los Angeles California, 90095, United States
UCLA University of California Los Angeles
Los Angeles California, 90095, United States
Westwood Bowyer Clinic, Peter Morton Medical Building
Los Angeles California, 90095, United States
UCLA Hematology Oncology
Santa Monica California, 90404, United States
UCLA Santa Monica Medical Center & Orthopaedic Hospital
Santa Monica California, 90404, United States
Smilow Cancer Hospital at Yale-New Haven
New Haven Connecticut, 06510, United States
Yale University
New Haven Connecticut, 06520, United States
Smilow Cancer Hospital Care Center at North Haven
North Haven Connecticut, 06473, United States
Massachusetts General Hospital
Boston Massachusetts, 02114, United States
Hackensack University Medical Center
Hackensack New Jersey, 07601, United States
John Theurer Cancer Center at Hackensack University Medical Center
Hackensack New Jersey, 07601, United States
Memorial Sloan-Kettering Cancer Center
New York New York, 10017, United States
Memorial Sloan Kettering Cancer Center
New York New York, 10022, United States
Tennessee Oncology, PLLC
Dickson Tennessee, 37055, United States
Tennessee Oncology, PLLC
Franklin Tennessee, 37067, United States
Tennessee Oncology, PLLC
Gallatin Tennessee, 37066, United States
Tennessee Oncology, PLLC
Hermitage Tennessee, 37076, United States
Tennessee Oncology, PLLC
Lebanon Tennessee, 37909, United States
Tennessee Oncology, PLLC
Murfreesboro Tennessee, 37129, United States
Tennessee Oncology, PLLC
Nashville Tennessee, 37203, United States
Tennessee Oncology, PLLC
Nashville Tennessee, 37205, United States
Tennessee Oncology, PLLC
Nashville Tennessee, 37207, United States
Tennessee Oncology, PLLC
Nashville Tennessee, 37211, United States
Tennessee Oncology, PLLC
Shelbyville Tennessee, 37160, United States
Tennessee Oncology, PLLC
Smyrna Tennessee, 37167, United States
University of Utah - Huntsman Cancer Institute - PPDS
Salt Lake City Utah, 84112, United States
Huntsman Cancer Hospital
Salt Lake City Utah, 84112, United States
Redwood Health Center - ARUP Lab Draw Location
Salt Lake City Utah, 84119, United States
John A Moran Eye Center
Salt Lake City Utah, 84132, United States
Royal Melbourne Hospital
Parkville Victoria, 3050, Australia
UZ Gasthuisberg
Leuven Vlaams Brabant, 3000, Belgium
Princess Margaret Cancer Centre
Toronto Ontario, M5G 2, Canada
Sir Mortimer B. Davis Jewish General Hospital
Montreal Quebec, H3T 1, Canada
Centre Régional de Lutte Contre Le Cancer Val D'aurelle Paul Lamarque
Montpellier , 34298, France
EDOG - Institut Claudius Regaud - PPDS
Toulouse , 31052, France
University Hospital of Koln
Köln Nordrhein-westfalen, 50937, Germany
Universitätsklinikum Essen
Essen , 45147, Germany
Ospedaliero Universitaria di Modena Policlinico
Modena , 41100, Italy
Pharmacy of National Cancer Center Hospital East
Kashiwa Chiba, 277-8, Japan
National Cancer Center Hospital
Chuo-ku Tokyo, 104-0, Japan
Samsung Medical Center - PPDS
Gangnam-Gu Seoul Teugbyeolsi, 06351, Korea, Republic of
Asan Medical Center - PPDS
Songpa-Gu Seoul Teugbyeolsi, 05505, Korea, Republic of
Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis
Amsterdam Noord-holland, 1066 , Netherlands
Erasmus MC
Rotterdam Zuid-holland, 3015 , Netherlands
Universitair Medisch Centrum Utrecht
Utrecht , 3584 , Netherlands
Oslo Myeloma Center - PPDS
Oslo , 0379, Norway
Instituto de Investigacion Oncologica Vall d'Hebron (VHIO) - EPON
Barcelona , 08035, Spain
Hospital Universitario 12 de Octubre
Madrid , 28026, Spain
Hospital Universitario Virgen del Rocio - PPDS
Sevilla , 41013, Spain
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How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 2

Estimated Enrollment:

156

Study ID:

NCT01719380

Recruitment Status:

Completed

Sponsor:


Pfizer

How clear is this clinincal trial information?

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