Study Of Weight-Based Versus Standard Dose Enoxaparin Thromboprophylaxis In High-Risk Hospitalized Cancer Patients

Inclusion Criteria:

Participants must have histologically or cytologically confirmed diagnosis of solid tumor malignancy, lymphoma or multiple myeloma.
Cancer diagnosis or received treatment (chemotherapy or radiotherapy) for malignancy within the previous 6 months

One or more Padua-based risk factor:

History of previous venous thromboembolic event (excluding superficial vein thrombosis)
Reduced mobility (ECOG performance status 3 or 4, see Appendix A)
Established hereditary thrombophilia (e.g. Factor V Leiden, G20210 prothrombin mutation, protein C or S deficiency, antithrombin deficiency).
Recent surgery within the last 30 days
Age ≥ 70 years
Congestive heart failure (NYHA class III or IV)
Complicated respiratory insufficiency (defined as an increased requirement for supplementary oxygen of at least 2L)
Acute myocardial infarction or ischemic stroke
Obesity (BMI ≥ 30)
Receiving hormonal agents (e.g. tamoxifen, estrogen, testosterone)
Acute infection (i.e. requiring antimicrobial therapy)
Age ≥ 18 years
Life expectancy of greater than 30 days
Platelet count ≥ 100,000/mcL
Creatinine < 1.5 mg/dL or estimated creatinine clearance ≥ 50 mL/min/1.73 m2
Ability to understand and the willingness to sign a written informed consent document
Weight between 50kg to 130 kg.

Exclusion Criteria:

History of allergic reactions attributed to heparin or low molecular weight heparin
Active bleeding or otherwise considered high risk for hemorrhage (e.g. known acute gastrointestinal ulcer)
Any history of significant hemorrhage (requiring hospitalization or transfusion) within the last 6 months (excluding hemorrhage during operative procedure).
History of heparin induced Thrombocytopenia
Presence of coagulopathy (PT or PTT> 1.2 x upper limit of normal)
Known diagnosis of disseminated intravascular coagulation
Currently receiving therapeutic anticoagulant therapy or dual antiplatelet therapy (eg. aspirin and clopidogrel)
Uncontrolled arterial hypertension (systolic blood pressure > 200mmHg, diastolic >110mmHg)
Active peptic ulcer disease
Bacterial Endocardititis
Received any type of Pharmacologic Thromboprophylaxis (e.g. low molecular weight heparin or heparin) for >48 hours during current hospitalization
Known brain metastases