Multiple Myeloma Clinical Trial

The TOTOM Trial: Tai Chi to Optimize Transplant Outcomes for Multiple Myeloma

Summary

The current proposal aims to test the feasibility of immune function analysis for Tai Chi Easy (TCE) intervention in multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT) with concurrent exploration of health related quality of life (HRQOL).

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Full Description

The current proposal aims to test the feasibility of immune function analysis for TCE intervention in MM patients undergoing ASCT with concurrent exploration of HRQOL. The data obtained from this trial will provide supporting data for a future randomized clinical trial evaluating the impact of TCE on immune function (incidence of ASCT related infectious complications, natural killer cell phenotype and activity, and myeloma remission rate (clonal plasma cell % at day 100, minimal residual disease (MRD)), with the evaluation of efficacy on improving HRQOL during ASCT. Successful completion of this CROC project will provide necessary data to support future grant applications, in particular the feasibility of immunoassay evaluation of MM patients undergoing ASCT.

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Eligibility Criteria

Inclusion Criteria:

Diagnosis of Multiple Myeloma planned to undergo bone marrow transplant
18 years or older
English speaking
General proficiency to read/write in English
Able to attend TCE training session per study protocol
ECOG performance status 0-1
Able to return to study center for routine post-transplant follow up (approximately Day 30 and Day 100)

Exclusion Criteria:

Currently performs Tai Chi, QiQong, or Yoga at least once weekly or more
Syncopal event in prior 60 days
Concurrent major depressive disorder or anxiety disorder (DSMIV) as determined by treating provider
Chronic dizziness or vestibular disorders
History of recurrent falls (>2 in the prior year)
Grade 3 or greater neuropathy
Grade 3 or greater spinal fracture

Study is for people with:

Multiple Myeloma

Estimated Enrollment:

12

Study ID:

NCT04760405

Recruitment Status:

Active, not recruiting

Sponsor:

University of Arizona

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There are 2 Locations for this study

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University of Arizona
Tucson Arizona, 85724, United States
Mayo Clinic
Jacksonville Florida, 32224, United States

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Study is for people with:

Multiple Myeloma

Estimated Enrollment:

12

Study ID:

NCT04760405

Recruitment Status:

Active, not recruiting

Sponsor:


University of Arizona

How clear is this clinincal trial information?

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