Multiple Sclerosis Clinical Trial

Antibiotic Treatment Trial Directed Against Chlamydia Pneumonia in Multiple Sclerosis

Summary

Multiple sclerosis (MS) is an inflammatory, demyelinating disease which affects the central nervous system (CNS). The etiology of MS is unknown, although the immune system appears to play a role. Many different infectious agents have been proposed as potential causes for MS, including Epstein-Barr virus, human herpesvirus 6, and coronaviruses. Recently Dr. Sriram at Vanderbilt University has found evidence for active Chlamydia pneumonia infection in the CNS of MS patients. These findings have been replicated in part by other laboratories.

The purpose of the current study is to test whether antibiotic treatment aimed at eradicating Chlamydia infection will reduce the disease activity in MS. The primary outcome measure will be reduction in new enhancing MS lesions on brain MRI. Forty patients will be entered into the trial. To be eligible, patients must have evidence of chlamydia infection in their spinal fluid and enhancing lesions on their pre-randomization MRI scans. Patients who meet these criteria will be randomized to either placebo or antibiotic therapy, and followed for 6 months on treatment.

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Eligibility Criteria

Patients with unequivocal diagnosis of multiple sclerosis and have evidence of C. pneumoniae infection in the cerebral spinal fluid

Study is for people with:

Multiple Sclerosis

Phase:

Phase 2

Estimated Enrollment:

40

Study ID:

NCT00043264

Recruitment Status:

Completed

Sponsor:

National Center for Research Resources (NCRR)

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There is 1 Location for this study

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University of Texas Medical School
Houston Texas, 77030, United States

How clear is this clinincal trial information?

Study is for people with:

Multiple Sclerosis

Phase:

Phase 2

Estimated Enrollment:

40

Study ID:

NCT00043264

Recruitment Status:

Completed

Sponsor:


National Center for Research Resources (NCRR)

How clear is this clinincal trial information?

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