Assessment of tDCS-Induced Neuronal Responses in Multiple Sclerosis (MS) With Advanced MRI

Inclusion Criteria:

Standardized SDMT Z-scores ≥3 standard deviations below mean
Able to understand all study instructions and supply written consent

Exclusion Criteria:

Extreme claustrophobia
History of mental retardation, pervasive developmental disorder or other neurological condition associated with cognitive impairment
Primary psychiatric disorder that would influence ability to participate
History of seizures or seizure disorder
History of head trauma in the past year (e.g., head injury, brain surgery) or medical device implanted in the head (such as Deep Brain Stimulator) or in the neck (such as a Vagus Nerve Stimulator)
Any skin disorder/sensitive skin (e.g., eczema, severe rashes), blisters, open wounds, burn including sunburns, cuts or irritation, or other skin defects which compromise the integrity of the skin at or near stimulation locations (where electrodes are placed)
Treatment for a communicable skin disorder currently or over the past 12 months
History of uncontrolled or labile hypertension.
Have any irremovable piercings, implantations or metallic-based tattoos
History of clinically significant abnormalities on electrocardiogram (EKG)
Pregnant or breastfeeding
Current substance abuse disorder