Effect of Robot-assisted Training on Foot Drop in Multiple Sclerosis

Inclusion Criteria:

Clinical diagnosis of MS by McDonald criteria (McDonald, Compston et al. 2001). EDSS level between 3.5-5.5, who report ambulation problems.
Presence of unilateral foot drop that is clinically apparent to the PI or PI designate.
Must be able to ambulate 25 feet without an assisting device.

Exclusion Criteria:

Cardiovascular: recent MI < 4 wk, uncontrolled HTN >190/110 mmHg.
History of uncontrolled diabetes.
Symptoms of orthostasis when standing up.
Circulatory problems, history of vascular claudication or pitting edema.
Unable to fully understand instructions in order to use the equipment or the process of the study.
Body weight over 150 kg.
Lower extremity injuries that limit range of motion or function.
Joint problems (hip or leg) that limit range of motion or cause pain with movement despite treatment.
Unstable fractures.
Pressure sores with any skin breakdown in areas in contact with the body harness or Lokomat apparatus.
Chronic and ongoing alcohol or drug abuse.
Pre-morbid, ongoing depression or psychosis.
Ongoing physical therapy.
Pregnancy (self-reported)
PI's determination of inability to complete the test protocol