Effects of a Home Based Walking Program Using Rhythmic Auditory Stimulation in Patients With Multiple Sclerosis

Inclusion Criteria:

age 18 years or older
diagnosis of MS per Mc Donald criteria
Ambulation Index score from 2 to 6 inclusive (clinically observable gait disturbance, whether the subject walks with no, unilateral, or bilateral support)
spastic paresis is the main neurologic impairment causing the gait disturbance, per investigator's judgment.

Exclusion Criteria:

neurologic impairments other than spastic paresis (e.g. cerebellar ataxia or sensory ataxia), or non-neurologic impairments (e.g. musculoskeletal problems) play a major role in the subject's gait disturbance, per investigator's judgment;
treatment for an MS exacerbation in the past 30 days;
severe co morbidity precluding participation in the study per investigator's judgment (e.g. severe cardiac or respiratory failure);
severe cognitive deficits precluding informed consent or preventing the subject from following study procedures safely
contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
pregnancy.