Multiple Sclerosis Clinical Trial
Efficacy and Safety of Fingolimod in Patients With Relapsing-remitting Multiple Sclerosis With Optional Extension Phase
Summary
This study assessed the safety, tolerability, and efficacy of 2 doses of oral fingolimod versus interferon β-1a to reduce the frequency of relapses in patients with relapsing-remitting multiple sclerosis.
View Eligibility Criteria
Eligibility Criteria
Inclusion Criteria:
Male and female patients between ages 18-55 with a diagnosis of multiple sclerosis (MS)
Patients with a relapsing-remitting disease course
Patients with Expanded Disability Status Scale (EDSS) score of 0-5.5
Exclusion Criteria:
Patients with other chronic disease of the immune system, malignancies, acute pulmonary disease, cardiac failure, etc
Pregnant or nursing women
Patients who cannot tolerate treatment with an interferon
Other protocol-defined inclusion/exclusion criteria applied to the study.
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There are 159 Locations for this study
See Locations Near You
North Central Neurology Associates, PC, 1809 Kress Street
Cullman Alabama, 35058, United States
Cullman Alabama, 35058, United States
Barrow Neurological Institute
Phoenix Arizona, 85013, United States
Phoenix Arizona, 85013, United States
The Neurology Center, 3907 Waring Road, Suite 3
Oceanside California, 92056, United States
Oceanside California, 92056, United States
Associated Neurologists, PC, 69 Sand Pit Road, Suite 300
Danbury Connecticut, 06810, United States
Danbury Connecticut, 06810, United States
Associated Neurologists of Southern CT, PC, 75 Kings Highway Cutoff
Fairfield Connecticut, 06824, United States
Fairfield Connecticut, 06824, United States
Yale University Multiple Sclerosis Center
New Haven Connecticut, 06510, United States
New Haven Connecticut, 06510, United States
University of Florida Health Science Center
Jacksonville Florida, 32209, United States
Jacksonville Florida, 32209, United States
Neurology Associates, PA, 301 N. Maitland Avenue, Suite A1
Maitland Florida, 32751, United States
Maitland Florida, 32751, United States
University of Miami, Department of Neurology
Miami Florida, 33136, United States
Miami Florida, 33136, United States
Neurological Associates
Pompano Beach Florida, 33060, United States
Pompano Beach Florida, 33060, United States
Roskamp Institute, 2040 Whitfield Ave.
Sarasota Florida, 34243, United States
Sarasota Florida, 34243, United States
AMO Corporation
Tallahassee Florida, 32308, United States
Tallahassee Florida, 32308, United States
Axiom Clinical Research of Florida, 2919 Swann Avenue, Suite 401
Tampa Florida, 33609, United States
Tampa Florida, 33609, United States
University of South Florida, Department of Neurology
Tampa Florida, 33612, United States
Tampa Florida, 33612, United States
The MS Center of Vero Beach
Vero Beach Florida, 32960, United States
Vero Beach Florida, 32960, United States
University of Kansas Medical Center
Kansas City Kansas, 66160, United States
Kansas City Kansas, 66160, United States
Mid America Neuroscience Institute, 8550 Marshall Drive, Suite 100
Lenexa Kansas, 66214, United States
Lenexa Kansas, 66214, United States
University Physician Group, #1 Barnes-Jewish Hospital Plaza, Suite 16304
Saint Louis Missouri, 63110, United States
Saint Louis Missouri, 63110, United States
Neuroscience and Spine Center
Charlotte North Carolina, 28207, United States
Charlotte North Carolina, 28207, United States
Raleigh Neurology Associates, 1540 Sunday Drive
Raleigh North Carolina, 27607, United States
Raleigh North Carolina, 27607, United States
Neurology & Neuroscience Associates, Inc
Akron Ohio, 44302, United States
Akron Ohio, 44302, United States
Northern Ohio Neuroscience, LLC
Bellevue Ohio, 44811, United States
Bellevue Ohio, 44811, United States
Cleveland Clinic
Cleveland Ohio, 44195, United States
Cleveland Ohio, 44195, United States
Oregon Neurology
Tualatin Oregon, 97062, United States
Tualatin Oregon, 97062, United States
University of Pittsburgh, Department of Neurology
Pittsburgh Pennsylvania, 15213, United States
Pittsburgh Pennsylvania, 15213, United States
Absher Neurology, 274-A Commonwealth Drive
Greenville South Carolina, 29615, United States
Greenville South Carolina, 29615, United States
Mountain Empire Neurological Associates, PC, 3183 West State Street, Suite 1201
Bristol Tennessee, 37620, United States
Bristol Tennessee, 37620, United States
Advanced Neurosciences Institute
Franklin Tennessee, 37064, United States
Franklin Tennessee, 37064, United States
Baylor College of Medicine
Houston Texas, 77030, United States
Houston Texas, 77030, United States
Private Practice, 3815 23rd Street
Lubbock Texas, 79410, United States
Lubbock Texas, 79410, United States
Integra Clinical Research, 4242 Medical Drive, Suite 6100
San Antonio Texas, 78229, United States
San Antonio Texas, 78229, United States
Swedish Neuroscience Institute
Seattle Washington, 98122, United States
Seattle Washington, 98122, United States
Rockwood Clinic, P.S.
Spokane Washington, 99202, United States
Spokane Washington, 99202, United States
West Virginia University Health Associates
Morgantown West Virginia, 26506, United States
Morgantown West Virginia, 26506, United States
Center for Neurological Disorders - Aurora St. Luke's Med Center
Milwaukee Wisconsin, 53215, United States
Milwaukee Wisconsin, 53215, United States
Ineba
Guarda Vieja 4435, Capital Federal Buenos Aires, 1428, Argentina
Guarda Vieja 4435, Capital Federal Buenos Aires, 1428, Argentina
Fundacion Rosarina de Neurorehabilitacion
Rosario Santa Fe, 2000, Argentina
Rosario Santa Fe, 2000, Argentina
Instituto de Neurociencias de Rosario
Rosario Santa Fe, 2000, Argentina
Rosario Santa Fe, 2000, Argentina
Hospital Italiano de Buenos Aires
Buenos Aires , C118A, Argentina
Buenos Aires , C118A, Argentina
Fundacion Lenox Cordoba
Cordoba , 5000, Argentina
Cordoba , 5000, Argentina
Hospital J. M. Ramos Mejia
General Urquiza 609, Buenos Aires , C1221, Argentina
General Urquiza 609, Buenos Aires , C1221, Argentina
FLENI
Montaneses 2325, Buenos Aires , C1428, Argentina
Montaneses 2325, Buenos Aires , C1428, Argentina
Strategic Health Evaluators
Chatswood New South Wales, 2067, Australia
Chatswood New South Wales, 2067, Australia
Royal Prince Alfred Hospital
Department of Medicine, Level, Missenden R, Camperdown New South Wales, 2050, Australia
Department of Medicine, Level, Missenden R, Camperdown New South Wales, 2050, Australia
Liverpool Hospital, Neurology Department, Health Services Building, 4th Floor, Goulburn and Campbell Street
Liverpool New South Wales, 2170, Australia
Liverpool New South Wales, 2170, Australia
Gosford Private Hospital
North Gosford New South Wales, 2250, Australia
North Gosford New South Wales, 2250, Australia
St George Private Hospital
Suite 7E, Level 5, South Street, Kogarah New South Wales, 2217, Australia
Suite 7E, Level 5, South Street, Kogarah New South Wales, 2217, Australia
Box Hill Hopsital, Level 3, 16 Arnold Street
Box Hill Victoria, 3128, Australia
Box Hill Victoria, 3128, Australia
Royal Melbourne Hospital
Suite 30, Grattan St., Parkbville Victoria, 3050, Australia
Suite 30, Grattan St., Parkbville Victoria, 3050, Australia
Landesklinikum St. Poelten, Probst-Ruehrer-Str. 4
St. Poelten Sankt Poelten, 3100, Austria
St. Poelten Sankt Poelten, 3100, Austria
Landes-Narvenklinik Wagner-Jauregg
Abteilung fuer Neurologie, Linz , A-402, Austria
Abteilung fuer Neurologie, Linz , A-402, Austria
Universitätsklinik f. Neurologie Innsbruck
Anichstrasse 35, Innsbruck , 6020, Austria
Anichstrasse 35, Innsbruck , 6020, Austria
Landes-Nervenklinik Christian Doppler Klinik
Ignaz Harrerstr. 79 , Salzburg , A-502, Austria
Ignaz Harrerstr. 79 , Salzburg , A-502, Austria
Evangel.Krankenh./Wien-Waehring Außenstelle
Vienna , 1010, Austria
Vienna , 1010, Austria
Univ.-Klinik fuer Neurologie AKH
Vienna , 1090, Austria
Vienna , 1090, Austria
Cliniques Universitaires Saint Luc
Avenue Hippocrate 10, Bruxelles , 1200, Belgium
Avenue Hippocrate 10, Bruxelles , 1200, Belgium
UZ Brussel
Laarbeeklaan 101, Brussels , 1090, Belgium
Laarbeeklaan 101, Brussels , 1090, Belgium
Nationaal Multiple Sclerose Centrum v.z.w
Melsbroek , 1820, Belgium
Melsbroek , 1820, Belgium
Regionaal Ziekenhuis Sint-Trudo - Campus Sint-Jozef
Sint-Truiden , 3800, Belgium
Sint-Truiden , 3800, Belgium
Hospital Sao Rafael
Salvador BA, 41256, Brazil
Salvador BA, 41256, Brazil
Hospital das Clincas - UNICAMP
Campinas SP, 13083, Brazil
Campinas SP, 13083, Brazil
Hospital das Clinicas da FMRPUSP
Ribeirao Preto SP, 48000, Brazil
Ribeirao Preto SP, 48000, Brazil
Irmandade da Santa Casa de Misericordia de Porto Alegre
Porto Alegre , RS 90, Brazil
Porto Alegre , RS 90, Brazil
Hospital dos Servidores do Estado
Rio de Janeiro , RJ 20, Brazil
Rio de Janeiro , RJ 20, Brazil
Hospital Universitario Gaffree e Guinle
Rio de Janeiro , RJ 20, Brazil
Rio de Janeiro , RJ 20, Brazil
Fraser Health MS Clinic, Burnaby Hospital, 3935 Kincaid Street
Vancouver British Columbia, V56 2, Canada
Vancouver British Columbia, V56 2, Canada
UBC MS Research, 2211 Westbrook Mall
Vancouver British Columbia, V6T 2, Canada
Vancouver British Columbia, V6T 2, Canada
Nepean Medical Centre, 1 Centrepointe Drive, Suite 407
Ottawa Ontario, K2G 6, Canada
Ottawa Ontario, K2G 6, Canada
St. Michael's Hospital, Chief, Division of Neurology, 30 Bond Street,Suite 3007 - Shuter Wing
Toronto Ontario, M5B 1, Canada
Toronto Ontario, M5B 1, Canada
Centre Hospitalier Universitaire de Sherbrooke, 3001 12th Avenue North
Fleurimont Quebec, J1H 5, Canada
Fleurimont Quebec, J1H 5, Canada
Charles Lemoyne Hospital
Greenfield Park Quebec, J4V 2, Canada
Greenfield Park Quebec, J4V 2, Canada
CHUM - Hopital Notre-Dame
Montreal Quebec, H2L 4, Canada
Montreal Quebec, H2L 4, Canada
Montreal Neurological Institute, 3801 University Street
Montreal Quebec, H3A 2, Canada
Montreal Quebec, H3A 2, Canada
The Ottawa General Hospital, 501 Smyth Rd.
Ottawa , K1H 8, Canada
Ottawa , K1H 8, Canada
Private Clinic, 48 Sidi Gaber St.
Alexandria , , Egypt
Alexandria , , Egypt
35, Dokki St., Apt. 4
Cairo , , Egypt
Cairo , , Egypt
Al Azhar University, 11 Talaat Harb St, Fourth Floor, Apt 18
Cairo , , Egypt
Cairo , , Egypt
Private Clinic, 35 Dokki St., Apt. 4
Cairo , , Egypt
Cairo , , Egypt
Private Clinic, 7 Batal Ahmed Abdelaziz St Abdeen
Cairo , , Egypt
Cairo , , Egypt
Hopital La Timone Cpcet, Rue Jean Moulin
Marseille , 13385, France
Marseille , 13385, France
Hopital Central, 29 Avenue du Marechal de Lattre de Tassigny
Nancy , 54035, France
Nancy , 54035, France
Hôpital Pellegrin
Place Amélie Raba Léon, Bordeaux Cedex , 33076, France
Place Amélie Raba Léon, Bordeaux Cedex , 33076, France
Hopital De Purpan
Place du Dr. Baylac, Toulouse Cedex , 31059, France
Place du Dr. Baylac, Toulouse Cedex , 31059, France
Centre Hospitalier de Poissy, 10 rue du Champ Gaillard
Poissy , 78303, France
Poissy , 78303, France
Hoppital Pasteur, Archet II, 30 avenue de la Voie
Romaine , 06602, France
Romaine , 06602, France
Investigational Site
Bamberg , 96049, Germany
Bamberg , 96049, Germany
Investigational Site
Berlin , 10713, Germany
Berlin , 10713, Germany
Investigational Site
Berlin , 13439, Germany
Berlin , 13439, Germany
Investigational Site
Bremen , 28177, Germany
Bremen , 28177, Germany
Investigational Site
Buchholz , 21244, Germany
Buchholz , 21244, Germany
Investigational Site
Dresden , 01307, Germany
Dresden , 01307, Germany
Investigational Site
Dusseldorf , 40225, Germany
Dusseldorf , 40225, Germany
Investigational Site
Erbach/Odenwald , 64711, Germany
Erbach/Odenwald , 64711, Germany
Investigational Site
Essen , 45122, Germany
Essen , 45122, Germany
Investigational Site
Freiburg , 79106, Germany
Freiburg , 79106, Germany
Investigational Site
Greifswald , 17475, Germany
Greifswald , 17475, Germany
Investigational Site
Hamburg , 66421, Germany
Hamburg , 66421, Germany
Investigational Site
Hannover , 30623, Germany
Hannover , 30623, Germany
Investigational Site
Heidelberg , 69120, Germany
Heidelberg , 69120, Germany
Investigational Site
Hennigsdorf , 16761, Germany
Hennigsdorf , 16761, Germany
Investigational Site
Koeln , 51109, Germany
Koeln , 51109, Germany
Investigational Site
Lengerich , 49525, Germany
Lengerich , 49525, Germany
Investigational Site
Mainz , 55131, Germany
Mainz , 55131, Germany
Investigational Site
Muenchen , 80331, Germany
Muenchen , 80331, Germany
Investigational Site
Munchen , 81675, Germany
Munchen , 81675, Germany
Investigational Site
Potsdam , 14471, Germany
Potsdam , 14471, Germany
Investigational Site
Teupitz , 15755, Germany
Teupitz , 15755, Germany
Investigational Site
Trier , 54292, Germany
Trier , 54292, Germany
Investigational Site
Tubingen , 72076, Germany
Tubingen , 72076, Germany
Investigational Site
Ulm , 89073, Germany
Ulm , 89073, Germany
Investigational Site
Ulm , 89075, Germany
Ulm , 89075, Germany
Investigational Site
Wermsdorf , 04779, Germany
Wermsdorf , 04779, Germany
Investigational Site
Wurzburg , 97070, Germany
Wurzburg , 97070, Germany
Univ. Hospital of Heraklion
Voutes, Heraklion Crete, GR 71, Greece
Voutes, Heraklion Crete, GR 71, Greece
Errikos Dinan General Hospital, 107 Mesogion Ave.
Athens , 11526, Greece
Athens , 11526, Greece
General Hospital of Athens G. Gennimatas, 154 Mesogeion Ave.
Athens , G-156, Greece
Athens , G-156, Greece
Metropolitan Hospital, Ethnarchou Makariou 6 & Eleftheriou Venizelou 1
Athens , GR 18, Greece
Athens , GR 18, Greece
General University Hospital of Patra-RIO
Patra - RIO , GR- 2, Greece
Patra - RIO , GR- 2, Greece
Ahepa University General Hospital of Thessaloniki, 1 Stilp. Kyriakidi Str.
Thessaloniki , GR 54, Greece
Thessaloniki , GR 54, Greece
Debreceni Egyetem Orvos es Egszstd. Centr.
Debrecen , 4012, Hungary
Debrecen , 4012, Hungary
Petz Aladár Megyei Oktató Kórház
Györ , 9024, Hungary
Györ , 9024, Hungary
Veszprem Megyei Csolnoky Ferenc Korhaz
Korhaz u. 1, Veszprem , H-820, Hungary
Korhaz u. 1, Veszprem , H-820, Hungary
Pecsi Tudomanyegyetem Neurologiai Klinika
Pecs , 7623, Hungary
Pecs , 7623, Hungary
Peterfy Sandor u. Hospital, Neurology
u. 8-20m, Budapest , 1076, Hungary
u. 8-20m, Budapest , 1076, Hungary
Uzsoki korhaz
Uzsoki u. 29., Budapest , 1145, Hungary
Uzsoki u. 29., Budapest , 1145, Hungary
Azienda Sanitaria Osp. S. Luigi
Gonzaga Orbassano, TO 10, Italy
Gonzaga Orbassano, TO 10, Italy
Ospedale S. Antonio Abate
via Pastori, 4, Gallarate VA, 21013, Italy
via Pastori, 4, Gallarate VA, 21013, Italy
Presidio Ospedaliero Roberto Binaghi
Cagliari , CA 09, Italy
Cagliari , CA 09, Italy
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna
Ferrara , FE 44, Italy
Ferrara , FE 44, Italy
Presidio Ospedaliero di Vaio Fidenza
Fidenza , PR 43, Italy
Fidenza , PR 43, Italy
Osp. Magg. Pol. Mangiagalli e Regina Elena - Fond. IRCCS
Milano , MI 20, Italy
Milano , MI 20, Italy
Az. Osp. Niguarda Ca' Granda
Milano , MI 20, Italy
Milano , MI 20, Italy
Presidio Ospedaliero di Montichiari
Montichiari , BS 25, Italy
Montichiari , BS 25, Italy
IRCCS Neurologico C. Mondino
Pavia , PV 27, Italy
Pavia , PV 27, Italy
Az. Osp. Ospedale Consorziale e Policlinico
piazza Giulio Cesare, 11 Bari , 70124, Italy
piazza Giulio Cesare, 11 Bari , 70124, Italy
Az. Osp. Ospedale S. Martino - Università degli Studi
via Antonio De Toni, 5, Genova , 16132, Italy
via Antonio De Toni, 5, Genova , 16132, Italy
Ist. Neurol. Mediterraneo Neuromed
Via Atinense, 18, Pozzilli , 86077, Italy
Via Atinense, 18, Pozzilli , 86077, Italy
Ospedali Riuniti Umberto I - GM Lancisi - G.Salesi
via Conca, 71, Torrette di Ancona , 60020, Italy
via Conca, 71, Torrette di Ancona , 60020, Italy
Osp. Clinicizzato Colle dell'Ara - Università G. D'Annunzio
via dei Vestini, 5 Chieti , 66100, Italy
via dei Vestini, 5 Chieti , 66100, Italy
Azienda Ospedaliera Sant'Andrea - Università La Sapienza
Via di Grottarossa, 1035/1039, Roma , 00189, Italy
Via di Grottarossa, 1035/1039, Roma , 00189, Italy
Azienda Ospedaliera di Padova - Università degli Studi
Via Giustiniani, 2, Padova , 35128, Italy
Via Giustiniani, 2, Padova , 35128, Italy
Az. Osp. Universitaria Policlinico Tor Vergata
via Montpellier, 1, Roma , 00133, Italy
via Montpellier, 1, Roma , 00133, Italy
Ospedale San Raffaele - IRCCS
via Olgettina, 48/60, Milano , 20132, Italy
via Olgettina, 48/60, Milano , 20132, Italy
Policlinico - Università degli Studi Federico II
via Pansini, 5, Napoli , 80131, Italy
via Pansini, 5, Napoli , 80131, Italy
Istituto di Scienze Neurologiche Università di Catania
via Santa Sofia, 78, Catania , 95123, Italy
via Santa Sofia, 78, Catania , 95123, Italy
Ospedale Bellaria Maggiore
via Toscana Nazionale, 17/19, Bologna , 40139, Italy
via Toscana Nazionale, 17/19, Bologna , 40139, Italy
Azienda Ospedaliera Careggi - Università degli Studi
Viale Giovan Battista Morgagni, 85, Firenze , 50134, Italy
Viale Giovan Battista Morgagni, 85, Firenze , 50134, Italy
National Cancer Center, 809 Madu 1-dong, Ilsan-gu
Kyunggi Goyang, 411-7, Korea, Republic of
Kyunggi Goyang, 411-7, Korea, Republic of
Samsung Medical Center
Seoul Korea, 135-7, Korea, Republic of
Seoul Korea, 135-7, Korea, Republic of
Yonsei Univ. Med. Center,Severance Hospital, 134 Shinchon-dong, Suedaemoon-ku
Seoul , 135-2, Korea, Republic of
Seoul , 135-2, Korea, Republic of
Kyung Pook National University Hospital
Taegu , 700-7, Korea, Republic of
Taegu , 700-7, Korea, Republic of
Hospital Fernando Fonseca
Amadora , 2720-, Portugal
Amadora , 2720-, Portugal
Hospitais da Universidade de Coimbra
Av. Dr. Bissaya Barreto, Coimbra , 3000-, Portugal
Av. Dr. Bissaya Barreto, Coimbra , 3000-, Portugal
Hospital Sto. António dos
Capuchos , , Portugal
Capuchos , , Portugal
Hospital de São João
Porto , 4200-, Portugal
Porto , 4200-, Portugal
Hospital de S. Bernardo
Rua Camilo Castelo Branco, Setubal , 2910-, Portugal
Rua Camilo Castelo Branco, Setubal , 2910-, Portugal
Complejo Hospitalario Carlos Haya
Avda. Carlos Haya, s/n, Málaga , 29010, Spain
Avda. Carlos Haya, s/n, Málaga , 29010, Spain
Hospital Universitario Virgen Macarena
Avenida Dr. Fedriani, 3, Sevilla , 41009, Spain
Avenida Dr. Fedriani, 3, Sevilla , 41009, Spain
Ciutat Sanitaria I, Universitaria De Bellvitge, c/o Feixa Llarga, Hospitalet de Llobregat
Barcelona , 08907, Spain
Barcelona , 08907, Spain
Hospital de Basurto
Bilbao , 48013, Spain
Bilbao , 48013, Spain
Hospital Clinico San Carlos
C/ Dr. Martin Lagos, s/n, Madrid , 28040, Spain
C/ Dr. Martin Lagos, s/n, Madrid , 28040, Spain
Unitat de Neuroimmunologia Clinica, Hospital Vall d'Hebron
EUI-planta 2, Pg. Vall d'Hebron 119-29, Barcelona , 08035, Spain
EUI-planta 2, Pg. Vall d'Hebron 119-29, Barcelona , 08035, Spain
Puerta de Huerro Univeristy Hospital
San Martin de Porres, 4, Madrid , 28035, Spain
San Martin de Porres, 4, Madrid , 28035, Spain
Hospital Universitario La Fe.
Valencia , 46009, Spain
Valencia , 46009, Spain
Universitätsspital Zuerich
Neurologische Klinik, Frauenklinikstrasse 26, Zuerich , 8091, Switzerland
Neurologische Klinik, Frauenklinikstrasse 26, Zuerich , 8091, Switzerland
Universitätsspital Basel, Neurochirugishen Poliklinik
Petersgraben 4, Basel , 4031, Switzerland
Petersgraben 4, Basel , 4031, Switzerland
Novartis
Investigational Site , , United Kingdom
Investigational Site , , United Kingdom
Charing Cross Hospital
London , W8 6R, United Kingdom
London , W8 6R, United Kingdom
The Walton Centre for Neurology and Neurosurgery
Lower Lane, Fazakerly, Liverpool , L9 7L, United Kingdom
Lower Lane, Fazakerly, Liverpool , L9 7L, United Kingdom
Norfolk & Norwich University Hospital
Norwick , NR4 7, United Kingdom
Norwick , NR4 7, United Kingdom
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