Multiple Sclerosis Clinical Trial

Examining Effects of Ocrevus on Cognitive Fatigue Using fMRI

Summary

The purpose of this research study is to investigate the effectiveness of MS Disease modifying medications on cognitive fatigue in persons with relapsing remitting multiple sclerosis (RRMS). Cognitive fatigue is the kind of fatigue that occurs after intense mental concentration as after a session of problem solving.

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Full Description

The researchers aim is to investigate the effects of disease modifying treatments on cognitive fatigue and on specific brain areas that have been shown to underlie cognitive fatigue in individuals with Multiple Sclerosis (MS). The researchers will investigate the effects on the cognitive fatigue that develops during the performance of a demanding task, and also on how cognitive fatigue changes as a function of duration of treatment.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Age between 18-64.
Relapsing remitting multiple sclerosis
Been newly prescribed a new disease modifying medication for MS (either Ocrevus or Copaxone)
or healthy volunteer who can speak English fluently.

Exclusion Criteria:

History of head injury, stroke, seizures, or any other significant neurological event other than MS
Flare up of MS symptoms within the past month.
History of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder.
Pacemaker or other implanted electrical device, brain stimulator, aneurysm clip (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and internal hearing aids [cochlear implants]), permanent eyeliner, implanted delivery pumps, or shrapnel fragments.
left handed.
Not able to have an MRI

Study is for people with:

Multiple Sclerosis

Estimated Enrollment:

60

Study ID:

NCT04448977

Recruitment Status:

Recruiting

Sponsor:

Kessler Foundation

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There is 1 Location for this study

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Kessler Foundation
West Orange New Jersey, 07052, United States More Info
Nancy B Moore, MA
Contact
973-324-8450
[email protected]
Angela Smith, M.A.
Contact
973-324-8448
[email protected]
John DeLuca, PhD
Principal Investigator
Ekaterina Dobryakova, PhD
Sub-Investigator
Helen Genova, PhD
Sub-Investigator
Glenn Wylie, PhD
Sub-Investigator
Krupa Pandey, MD
Sub-Investigator
Florian Thomas, MD
Sub-Investigator

How clear is this clinincal trial information?

Study is for people with:

Multiple Sclerosis

Estimated Enrollment:

60

Study ID:

NCT04448977

Recruitment Status:

Recruiting

Sponsor:


Kessler Foundation

How clear is this clinincal trial information?

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