Multiple Sclerosis Clinical Trial

Examining the Effects of a Remotely-delivered, Racially-tailored Exercise Training Program for Immediate and Sustained Improvements in Walking Dysfunction, Symptoms, and Health-related Quality of Life (HRQOL) Among African-Americans With Multiple Sclerosis (MS) Residing in Rural Environments.

Summary

The proposed project involves a high-quality randomized controlled (RCT) design that examines the effects of a remotely-delivered, racially-tailored exercise training program for immediate and sustained improvement in walking dysfunction, symptoms, and health-related quality of life (HRQOL) among African-Americans with MS residing in rural environments. The primary analysis will test the hypothesis that those who are randomly assigned into the intervention condition (i.e., exercise training) will demonstrate (a) improvements in outcomes from baseline that (b) are sustained over 4-months of follow-up compared with those in the control condition (i.e., stretching).

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Full Description

There is a lack of evidence from high-quality randomized controlled trials (RCTs) of exercise training for African-Americans with multiple sclerosis (MS), as only 1.7% of participants in physical activity and exercise research involving persons with MS identify as African-American. The population of African-Americans with MS deserves equal and focal research that addresses the unique challenges of MS in the African-American rural residing community. We uniquely address this population with a highly-developed and refined exercise training program that is racially-tailored for the target population. We further provide a highly-developed and refined exercise training program that can be undertaken in one's home and/or local community, and does not require facility access that is extremely limited in the target, rural residing population of persons with MS. The program is further tailored based on qualitative research and addresses the unique needs of the African-American community with MS. There is no other research program this advanced in study refinement and design for immediate integration into a high-quality RCT for changing the lives of African-Americans with MS who reside in rural communities of the Southeastern portion of the United States. If successful, the study, as designed, will provide Class I evidence that is necessary for immediate implementation after trial completion through insurance providers and healthcare providers, including physical therapists, rehabilitation practitioners, and community health workers/providers. This program further aligns with recently developed and highly-refined conceptual and practice models for implementation of exercise into the care of persons with MS.

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Eligibility Criteria

Inclusion Criteria:

English as primary language
Identify as African-American or Black
Age of 18 years or older
Diagnosis of MS
Relapse free in the past 30 days
Internet and email access
Willingness to complete the outcome questionnaires
Willingness to undergo randomization
Insufficient physical activity (not meeting current physical activity guidelines based on GLTEQ)
Mild-moderate ambulatory disability (MSWS-12 score between 25-49 & PDDS score between 2-4)

Exclusion Criteria:

Individuals not meeting above inclusion criteria
Individuals with moderate to high risk for contraindications of possible injury or death when undertaking strenuous or maximal exercise (PARQ).

Study is for people with:

Multiple Sclerosis

Estimated Enrollment:

100

Study ID:

NCT05516537

Recruitment Status:

Recruiting

Sponsor:

University of Illinois at Chicago

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University of Illinois at Chicago
Chicago Illinois, 60612, United States More Info
Robert W Motl, PhD
Contact
205-975-1306
[email protected]
Edson Flores, MPH
Contact
312-413-4967
[email protected]
Robert W Motl, PhD
Principal Investigator
Edson Flores, MPH
Sub-Investigator

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Study is for people with:

Multiple Sclerosis

Estimated Enrollment:

100

Study ID:

NCT05516537

Recruitment Status:

Recruiting

Sponsor:


University of Illinois at Chicago

How clear is this clinincal trial information?

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