Lubiprostone in Patients With Multiple Sclerosis Associated Constipation

Inclusion Criteria:

Multiple Sclerosis
Chronic Constipation defined as < 3 spontaneous bowel movements per week by history and confirmed by diary during the 14 day washout period.
Women of child-bearing potential must agree to use adequate birth control.

Exclusion Criteria:

history of other clinically significant medical or psychiatric disorders or suicidal ideation.
Subjects who have a suspicion of a mechanical bowel obstruction by clinical evaluation prior to dosing that include nausea, vomiting, abdominal pain or distention.
Subjects with a positive urine pregnancy test prior to dosing.
Medication changes within one month prior to visit one.
Corticosteroid use within 2 months prior to visit one.
Age<18.
Known intolerance to lubiprostone.
Inability to perform any required study procedures.