Multiple Sclerosis Clinical Trial

Multimodal Exercise Training to Reduce Frailty in People With Multiple Sclerosis

Summary

Study Significance: This proposed investigation is designed to examine the feasibility of an exercise-based intervention to reduce frailty in people living with MS. The proposed research will be the first to establish the feasibility of targeting frailty in pwMS and will begin to examine the dynamic nature of frailty in MS. These advances will pave the way for planned prospective studies toward effective targets for diagnostics, and rehabilitation of frailty in MS.

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Eligibility Criteria

Inclusion Criteria:

Subjects must be aged 40-65 years old to be enrolled in this study.
Subjects must meet 3 of 5 frailty criteria (weight loss; exhaustion; weakness; slowness; inactivity) to be considered.
Subjects must have a confirmed diagnosis of MS by the treating neurologist
be free from MS relapses in the last 30 days
have an Expanded Disability Status Scale (EDSS) score ≤ 6.0
be fluent in spoken and written English.

Exclusion Criteria:

unable to walk unassisted for at least ten meters
are diagnosed with other clinically important neurological conditions (such as Parkinson's Disease, epilepsy, etc.)
exhibit severe cognitive impairment (as determined by a Mini-Cog score <3)
are diagnosed with active psychiatric problems.
unstable cardiovascular conditions (e.g., malignant arrhythmias, critical mitral stenosis, clinically severe left ventricular outflow obstruction, critical proximal coronary artery stenosis)
arthritis of the lower limbs
acute lower back or lower limbs pain
rheumatic and/or severe orthopedic problems that may interfere with resistance training.

Study is for people with:

Multiple Sclerosis

Estimated Enrollment:

24

Study ID:

NCT06042244

Recruitment Status:

Enrolling by invitation

Sponsor:

University of Kansas Medical Center

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There is 1 Location for this study

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Landon Center On Aging
Kansas City Kansas, 66103, United States

How clear is this clinincal trial information?

Study is for people with:

Multiple Sclerosis

Estimated Enrollment:

24

Study ID:

NCT06042244

Recruitment Status:

Enrolling by invitation

Sponsor:


University of Kansas Medical Center

How clear is this clinincal trial information?

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