Neuromuscular Electrical Stimulation and Mobility in Multiple Sclerosis

Inclusion Criteria:

Able to read, understand, and speak English to ensure safe participation in the project
Difficulties with walking
On stable doses of Ampyra, provigil, or other symptomatic-treating medications
No systemic steroids within the last 30 days
Not currently exercising more than 2x/wk
Able to arrange own transportation to and from the laboratories
Provide informed consent, including willingness to be randomly assigned to one of the two groups

Exclusion Criteria:

Documented MS-related relapse in the last 3 months
Medical diagnosis or condition that is considered to be an absolute or relative contraindication to participating in exercise training, such as major renal, pulmonary, hepatic, cardiac, gastrointestinal, HIV, cancer (other than treated basal cell cancer), other neurological disorders, or pregnancy
Poorly controlled diabetes mellitus or hypertension
History of seizure disorders
Alcohol dependence or abuse (≥2 drinks/day), or present history (last 6 months) of drug abuse
Inability to attend exercise sessions 3 days per week for 6 weeks