Multiple Sclerosis Clinical Trial
Prospective Investigation of Multiple Sclerosis in the Three Rivers Region
Summary
In this longitudinal prospective natural history study of multiple sclerosis (MS), the overarching goal is to understand the factors that influence individual variation in disease trajectory and treatment response and pave the way for realizing precision medicine in MS. Because MS is a chronic neurological disorder, this observational cohort study will span a 30-year time frame.
Full Description
Research Activities: Initial Questionnaire, Questionnaire for Self-Reported Outcomes, Biological Sample Collection (Blood, Stool, Urine, Cerebrospinal fluid), Genetic Analysis, Standard Quantitative Assessment of Function, Cognitive Assessment, Neuroimaging, Biometric Sensors, Social Network Questionnaire, Connor-Davidson Resilience Scale, NEO Five-Factor Inventory, and the COVID19 Response Surveys.
Eligibility Criteria
Inclusion Criteria:
Inclusion criteria for MS patients include:
willing and able to give consent
age 7 years or older
diagnosis of multiple sclerosis or related disorders, including a first central nervous system demyelinating episode with a positive MRI scan or abnormal MRI scans characteristic of MS but no clinical symptoms of the disease
For healthy controls:
Age 7 years or older
Willing and able to provide consent (for >=18 years) or assent with permission from at least one of the child's parents (for <18 years)
No known personal history of multiple sclerosis or related disorders
No other chronic diseases
Family members, unrelated household controls, or controls from the general population could be eligible
There is no exclusion criteria.
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