Trial of Analgesia With Lidocaine or Extended-release Oxycodone for Neuropathic Pain Treatment in Multiple Sclerosis

Inclusion Criteria:

"Definite MS" as defined by revised McDonald criteria.
Bilateral distal symmetric burning pain involving both feet for at least three months.
Baseline weekly average pain rating equal to four or greater on 0-10 numerical scale.
Stable MS medication and pain-related medications for 8 weeks prior to screening.
Must come to Research Center for appointments

Exclusion Criteria:

Topical treatment with lidocaine, capsaicin, or other topical analgesics within 3 months prior to screening.
Any treatment with opioid analgesics or tramadol within 3 months prior to screening.
Hypersensitivity to Lidoderm, lidocaine, or other local anesthetics.
Hypersensitivity or inability to tolerate opioid analgesics.
Current treatment with a total of 3 or more antidepressant or anticonvulsant drugs for pain.
Current treatment with Class I anti-arrhythmic agents at baseline.
Beck Depression Inventory score > 16 or clinically significant depression or dementia.
History of suicide attempt or current intent or plan.
History of excessive alcohol use or any illicit drug use within the past 2 years.
Lack of adequate birth control in pre-menopausal women of childbearing age.
Other pain more severe than lower extremity burning pain.
Open skin lesions in the area where the lidocaine patch is to be applied.
Cancer within the previous 5 years other than skin cancer.
MS exacerbation or any treatment with corticosteroids within 3 months prior to screening.
History of peripheral neuropathy, lower limb amputation, or another neuromuscular syndrome or systemic disorder known to be associated with sensory neuropathy.
Does not meet criteria of baseline lab values at screening visit.
Nerve conduction studies consistent with peripheral neuropathy.