Myelodysplastic Syndrome Clinical Trial

Clinical Trial Finder Myelodysplastic Syndrome Trials

A Phase I Study of CYC140, a PLK-1 Inhibitor, in Advanced Leukemias or MDS

See Locations Near You

Summary

A Phase I Pharmacologic Study of CYC140, a polo-like kinase 1 inhibitor, in Patients with Advanced Leukemias or Myelodysplastic Syndromes

View Full Description

Full Description

This is a First in Human, open-label, single arm, dose escalation study in patients with advanced leukemias or myelodysplastic syndromes. Patients will receive CYC140 as a 1 hr infusion once a week for 2 weeks followed by 1 week of rest on an outpatient basis. One treatment cycle is 3 weeks.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Diagnosis of relapsed or refractory advanced leukemias or MDS
ECOG 0-2
Adequate renal function
Adequate liver function
≥ 2 weeks from prior chemotherapy, radiation therapy or major surgery
≥ 4 weeks from other investigational anticancer therapy
Agree to practice effective contraception

Exclusion Criteria:

Known CNS involvement by leukemia
Currently receiving radiotherapy, biological therapy, or any other investigational agents
Uncontrolled intercurrent illness
Pregnant or lactating
Known to be HIV-positive
Known active hepatitis B and/ or hepatitis C infection

Study is for people with:

Myelodysplastic Syndrome

Phase:

Phase 1

Estimated Enrollment:

50

Study ID:

NCT03884829

Recruitment Status:

Recruiting

Sponsor:

Cyclacel Pharmaceuticals, Inc.

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There is 1 Location for this study

See Locations Near You

MD Anderson Cancer Center
Houston Texas, 77030, United States More Info
Hind Alazzawi
Contact
713-794-4823
[email protected]

How clear is this clinincal trial information?

Study is for people with:

Myelodysplastic Syndrome

Phase:

Phase 1

Estimated Enrollment:

50

Study ID:

NCT03884829

Recruitment Status:

Recruiting

Sponsor:


Cyclacel Pharmaceuticals, Inc.

How clear is this clinincal trial information?

Clinical Trial Resources

Why I’d Choose a Clinical Trial For Myself
SurvivorNet’s Guide To Clinical Trials: What Are They And Are They Right for You?
Clinical Trials Can be Life-Saving for Some
×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.

Please confirm you are a US based health care provider:

Yes, I am a health care Provider No, I am not a health care provider