Myelodysplastic Syndrome Clinical Trial
Collection of Samples From Patients With MDS
Summary
The purpose of this study is to collect information and bone marrow, blood, saliva, cheek cells and skin to be used in the laboratory to assist the sponsor in identifying a new way of treating MDS.
Full Description
Goals of the study:
The purpose of this study is to collect the blood and marrow samples, and non-involved fibroblasts, that are required to identify the unique, personalized array of mutation-driven neoantigens that are expressed by the subject's MDS cells and to assess the feasibility of immunizing and expanding one or more of the patient's T cells ex vivo for investigation of their use as adoptive cellular immunotherapy.
Eligibility Criteria
Patients must meet the following initial inclusion criteria:
Diagnosis or suspected diagnosis of MDS or CCUS
Age 18 or older
Patient exclusion criteria:
Currently receiving or within 3 months has received hypomethylating agent(s), lenalidomide, cytotoxic agents, or within the previous 4 weeks corticosteroids > 5 mg prednisone daily or any other immunosuppressants
Previous allogenic transplant
Inability to provide consent
Prisoners
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There are 2 Locations for this study
Irvine California, 92868, United States More Info
Principal Investigator
La Jolla California, 92093, United States More Info
Principal Investigator
Sub-Investigator
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