Myelodysplastic Syndrome Clinical Trial
Genetic Study of Children With Soft Tissue Sarcoma or Rhabdomyosarcoma
Summary
RATIONALE: Determination of genetic markers for soft tissue sarcoma or rhabdomyosarcoma may help doctors identify patients who are at risk for therapy-related leukemia.
PURPOSE: Clinical trial to study genetic testing of children with soft tissue sarcoma or rhabdomyosarcoma to identify children who are at risk of developing leukemia from the chemotherapy used to treat sarcoma.
Full Description
OBJECTIVES:
Identify genetically susceptible patients to therapy-induced myelodysplastic syndrome or acute myelogenous leukemia (t-MDS/AML) prior to initiation of high-dose chemotherapy for sarcoma.
Identify patients who are at increased risk of t-MDS/AML during or after therapy.
OUTLINE: Blood is collected from patients at diagnosis (preferably before chemotherapy or transfusion), at end of therapy, and at 6 months, 1 year, 2 years, and 3 years after therapy.
Blood specimens are examined by clonality analysis (HUMARA), variant cell frequency (glycophorin A assay), GST NAT2/CYP1A1 genotyping, microsatellite instability, and ras mutation detection (single strand conformation polymorphism and sequencing of mutant alleles).
Patients do not receive the results of the genetic testing and the results do not influence the type or duration of treatment.
PROJECTED ACCRUAL: A total of 321 patients will be accrued for this study within 4 years.
Eligibility Criteria
DISEASE CHARACTERISTICS:
Diagnosis of sarcoma including:
Rhabdomyosarcoma
Ewing's sarcoma
Primitive neuroectodermal tumor
Fibrosarcoma
Malignant peripheral nerve sheath tumor
Synovial cell sarcoma
Osteosarcoma
Other soft tissue sarcoma
Must be currently receiving intensive or high-dose chemotherapy for sarcoma
PATIENT CHARACTERISTICS:
Age:
Children
Performance status:
Not specified
Life expectancy:
Not specified
Hematopoietic:
Not specified
Hepatic:
Not specified
Renal:
Not specified
PRIOR CONCURRENT THERAPY:
Biologic therapy
Not specified
Chemotherapy
See Disease Characteristics
Endocrine therapy
Not specified
Radiotherapy
Not specified
Surgery
Not specified
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There are 95 Locations for this study
Downey California, 90242, United States
Long Beach California, 90806, United States
Los Angeles California, 90095, United States
Madera California, 93638, United States
San Francisco California, 94115, United States
Stanford California, 94305, United States
Farmington Connecticut, 06360, United States
Wilmington Delaware, 19899, United States
Washington District of Columbia, 20007, United States
Washington District of Columbia, 20010, United States
Fort Myers Florida, 33901, United States
Gainesville Florida, 32610, United States
Jacksonville Florida, 32207, United States
Miami Florida, 33155, United States
Miami Florida, 33176, United States
Orlando Florida, 32803, United States
St. Petersburg Florida, 33701, United States
Tampa Florida, 33607, United States
West Palm Beach Florida, 33407, United States
Atlanta Georgia, 30322, United States
Savannah Georgia, 31403, United States
Chicago Illinois, 60614, United States
Des Moines Iowa, 50309, United States
Louisville Kentucky, 40232, United States
New Orleans Louisiana, 70118, United States
Bangor Maine, 04401, United States
Scarborough Maine, 04074, United States
Ann Arbor Michigan, 48109, United States
Detroit Michigan, 48201, United States
Flint Michigan, 48503, United States
Grand Rapids Michigan, 49503, United States
Grosse Pointe Woods Michigan, 48236, United States
Kalamazoo Michigan, 49007, United States
Minneapolis Minnesota, 55404, United States
Minneapolis Minnesota, 55455, United States
Rochester Minnesota, 55905, United States
Jackson Mississippi, 39216, United States
Columbia Missouri, 65203, United States
Kansas City Missouri, 64108, United States
St. Louis Missouri, 63110, United States
Hackensack New Jersey, 07601, United States
Bronx New York, 10461, United States
Brooklyn New York, 11220, United States
Buffalo New York, 14263, United States
New York New York, 10016, United States
New York New York, 10029, United States
New York New York, 10032, United States
Stony Brook New York, 11794, United States
Syracuse New York, 13210, United States
Chapel Hill North Carolina, 27599, United States
Charlotte North Carolina, 28232, United States
Charlotte North Carolina, 28233, United States
Winston-Salem North Carolina, 27157, United States
Fargo North Dakota, 58122, United States
Akron Ohio, 44308, United States
Cincinnati Ohio, 45229, United States
Cleveland Ohio, 44195, United States
Columbus Ohio, 43205, United States
Dayton Ohio, 45404, United States
Youngstown Ohio, 44501, United States
Oklahoma City Oklahoma, 73104, United States
Portland Oregon, 97227, United States
Hershey Pennsylvania, 17033, United States
Philadelphia Pennsylvania, 19134, United States
Pittsburgh Pennsylvania, 15213, United States
Greenville South Carolina, 29605, United States
Knoxville Tennessee, 37901, United States
Nashville Tennessee, 37232, United States
Amarillo Texas, 79106, United States
Dallas Texas, 75230, United States
Dallas Texas, 75390, United States
Fort Worth Texas, 76104, United States
Lubbock Texas, 79410, United States
San Antonio Texas, 78229, United States
San Antonio Texas, 78229, United States
Temple Texas, 76508, United States
Fairfax Virginia, 22042, United States
Norfolk Virginia, 23507, United States
Spokane Washington, 99204, United States
Charleston West Virginia, 25302, United States
Huntington West Virginia, 25701, United States
Green Bay Wisconsin, 54307, United States
Marshfield Wisconsin, 54449, United States
Herston, Brisbane Queensland, QLD 4, Australia
Parkville Victoria, 3052, Australia
Perth Western Australia, 6001, Australia
Vancouver British Columbia, V6H 3, Canada
Winnipeg Manitoba, R3E 0, Canada
Halifax Nova Scotia, B3K 6, Canada
Hamilton Ontario, L8N 3, Canada
Kingston Ontario, K7L 5, Canada
Ottawa Ontario, K1H 8, Canada
Toronto Ontario, M5G 1, Canada
Montreal Quebec, H3T 1, Canada
Ste-Foy Quebec, G1R 2, Canada
Saskatoon Saskatchewan, S7N 4, Canada
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