Myeloproliferative Neoplasms Clinical Trial
A Phase III Study of Dasatinib vs Imatinib in Patients With Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia
Summary
The purpose of this clinical research study is to compare the confirmed complete cytogenetic response of dasatinib with that of imatinib within 12 months after randomization in patients with newly diagnosed chronic-phase Philadelphia positive chronic myeloid leukemia. The safety of this treatment will also be studied.
View Eligibility Criteria
Eligibility Criteria
Key Inclusion Criteria:
Male or female, aged 18 years and older
Chronic phase, Philadelphia Chromosome-positive chronic myeloid leukemia (CML)
Eastern Cooperative Oncology Group Performance Status score of 0-2
Key Exclusion Criteria:
Pleural Effusion
Uncontrolled cardiovascular disease
Significant bleeding disorder unrelated to CML
Prior treatment with interferon/imatinib/dasatinib/anti-CML systemic treatments except anagrelide/hydroxyurea
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There are 101 Locations for this study
See Locations Near You
Molecular Md
Portland Oregon, 97219, United States
Portland Oregon, 97219, United States
Local Institution
Capital Federal Buenos Aires, 1280, Argentina
Capital Federal Buenos Aires, 1280, Argentina
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Capital Federal Buenos Aires, C1114, Argentina
Capital Federal Buenos Aires, C1114, Argentina
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Buenos Aires , 1021, Argentina
Buenos Aires , 1021, Argentina
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Waratah New South Wales, 2298, Australia
Waratah New South Wales, 2298, Australia
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Brisbane Queensland, 4029, Australia
Brisbane Queensland, 4029, Australia
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Greenslopes Queensland, 4120, Australia
Greenslopes Queensland, 4120, Australia
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Perth Western Australia, WA 60, Australia
Perth Western Australia, WA 60, Australia
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Innsbruck , 6020, Austria
Innsbruck , 6020, Austria
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Wien , 1090, Austria
Wien , 1090, Austria
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Brugge , 8000, Belgium
Brugge , 8000, Belgium
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Bruxelles , 1200, Belgium
Bruxelles , 1200, Belgium
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Curitiba Parana, 80060, Brazil
Curitiba Parana, 80060, Brazil
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Campinas Sao Paulo, 13083, Brazil
Campinas Sao Paulo, 13083, Brazil
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Jau Sao Paulo, 17210, Brazil
Jau Sao Paulo, 17210, Brazil
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Rio De Janeiro , 20230, Brazil
Rio De Janeiro , 20230, Brazil
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Sao Paulo , 01401, Brazil
Sao Paulo , 01401, Brazil
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Sao Paulo , 05403, Brazil
Sao Paulo , 05403, Brazil
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Santiago Metropolitana, , Chile
Santiago Metropolitana, , Chile
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Beijing Beijing, 10004, China
Beijing Beijing, 10004, China
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Fuzhou Fujian, 35000, China
Fuzhou Fujian, 35000, China
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Shanghai Shanghai, 20002, China
Shanghai Shanghai, 20002, China
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Tianjin Tianjin, 30002, China
Tianjin Tianjin, 30002, China
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Colombia Bogota, , Colombia
Colombia Bogota, , Colombia
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Bogota , , Colombia
Bogota , , Colombia
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Brno , 625 0, Czech Republic
Brno , 625 0, Czech Republic
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Hradec Kralove , 500 0, Czech Republic
Hradec Kralove , 500 0, Czech Republic
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Olomouc , 775 2, Czech Republic
Olomouc , 775 2, Czech Republic
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Prague 2 , 128 2, Czech Republic
Prague 2 , 128 2, Czech Republic
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Aarhus , 8000, Denmark
Aarhus , 8000, Denmark
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Nantes Cedex 1, 44093, France
Nantes Cedex 1, 44093, France
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Brest Cedex 02 , 29609, France
Brest Cedex 02 , 29609, France
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Lille Cedex , 59037, France
Lille Cedex , 59037, France
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Limoges , 87042, France
Limoges , 87042, France
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Montpellier Cedex , 34295, France
Montpellier Cedex , 34295, France
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Paris Cedex 10 , 75475, France
Paris Cedex 10 , 75475, France
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Paris , 75015, France
Paris , 75015, France
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Pierre Benite Cedex , 69495, France
Pierre Benite Cedex , 69495, France
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Poitiers Cedex , 86021, France
Poitiers Cedex , 86021, France
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Rennes , 35033, France
Rennes , 35033, France
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Strasbourg Cedex , 67091, France
Strasbourg Cedex , 67091, France
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Toulouse Cedex 09 , 31059, France
Toulouse Cedex 09 , 31059, France
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Vandoeuvre Les Nancy , 54511, France
Vandoeuvre Les Nancy , 54511, France
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Berlin , 13353, Germany
Berlin , 13353, Germany
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Rostock , 18055, Germany
Rostock , 18055, Germany
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Tuebingen , 72076, Germany
Tuebingen , 72076, Germany
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Ulm , 89081, Germany
Ulm , 89081, Germany
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Thessaloniki , 57010, Greece
Thessaloniki , 57010, Greece
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Budapest , 1097, Hungary
Budapest , 1097, Hungary
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Debrecen , 4012, Hungary
Debrecen , 4012, Hungary
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Vellore Tamilnadu, 63200, India
Vellore Tamilnadu, 63200, India
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Ahmedabad , 38000, India
Ahmedabad , 38000, India
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Cochin , 68230, India
Cochin , 68230, India
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Mumbai , 40001, India
Mumbai , 40001, India
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Mumbai , 40001, India
Mumbai , 40001, India
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Mumbai , 40001, India
Mumbai , 40001, India
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Trivandrum , 69501, India
Trivandrum , 69501, India
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Bologna , 40138, Italy
Bologna , 40138, Italy
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Catania , 95124, Italy
Catania , 95124, Italy
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Monza (mb) , 20900, Italy
Monza (mb) , 20900, Italy
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Orbassano (to) , 10043, Italy
Orbassano (to) , 10043, Italy
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Pavia , 27100, Italy
Pavia , 27100, Italy
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Roma , 00144, Italy
Roma , 00144, Italy
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Roma , 00161, Italy
Roma , 00161, Italy
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Nagoya Aichi, 466-8, Japan
Nagoya Aichi, 466-8, Japan
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Kamogawa-shi Chiba, 29686, Japan
Kamogawa-shi Chiba, 29686, Japan
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Fukuoka-shi Fukuoka, 814-0, Japan
Fukuoka-shi Fukuoka, 814-0, Japan
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Morioka-shi Iwate, 020-8, Japan
Morioka-shi Iwate, 020-8, Japan
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Kagoshima-shi Kagoshima, 890-0, Japan
Kagoshima-shi Kagoshima, 890-0, Japan
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Yokohama Kanagawa, 232-0, Japan
Yokohama Kanagawa, 232-0, Japan
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Kyoto-shi Kyoto, 60285, Japan
Kyoto-shi Kyoto, 60285, Japan
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Sendai Miyagi, , Japan
Sendai Miyagi, , Japan
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Okayama-shi Okayama, 70085, Japan
Okayama-shi Okayama, 70085, Japan
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Osaka-shi Osaka, 545-8, Japan
Osaka-shi Osaka, 545-8, Japan
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Bunkyo-ku Tokyo, 113-8, Japan
Bunkyo-ku Tokyo, 113-8, Japan
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Shinagawa-ku Tokyo, 14186, Japan
Shinagawa-ku Tokyo, 14186, Japan
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Seoul , 137-0, Korea, Republic of
Seoul , 137-0, Korea, Republic of
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Seoul , 138-7, Korea, Republic of
Seoul , 138-7, Korea, Republic of
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Mexico D.f. Distrito Federal, 14000, Mexico
Mexico D.f. Distrito Federal, 14000, Mexico
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Mexico, D. F. Distrito Federal, 06726, Mexico
Mexico, D. F. Distrito Federal, 06726, Mexico
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Mexico Distrito Federal, 02990, Mexico
Mexico Distrito Federal, 02990, Mexico
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Monterrey Nuevo Leon, 64460, Mexico
Monterrey Nuevo Leon, 64460, Mexico
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Culiacan Sinaloa, 80230, Mexico
Culiacan Sinaloa, 80230, Mexico
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Groningen , 9700 , Netherlands
Groningen , 9700 , Netherlands
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Nijmegen , 6500 , Netherlands
Nijmegen , 6500 , Netherlands
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Arequipa , , Peru
Arequipa , , Peru
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Lima , 11, Peru
Lima , 11, Peru
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Lima , 34, Peru
Lima , 34, Peru
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Chorzow , 41-50, Poland
Chorzow , 41-50, Poland
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Krakow , 31501, Poland
Krakow , 31501, Poland
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Lodz , 93-51, Poland
Lodz , 93-51, Poland
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Poznan , 60869, Poland
Poznan , 60869, Poland
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Warsaw , 02776, Poland
Warsaw , 02776, Poland
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Moscow , 12516, Russian Federation
Moscow , 12516, Russian Federation
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Rostov-on-don , 34402, Russian Federation
Rostov-on-don , 34402, Russian Federation
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St.petersburg , 19702, Russian Federation
St.petersburg , 19702, Russian Federation
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Singapore , 16986, Singapore
Singapore , 16986, Singapore
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A Coruna , 15706, Spain
A Coruna , 15706, Spain
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Barcelona , 08003, Spain
Barcelona , 08003, Spain
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Barcelona , 08036, Spain
Barcelona , 08036, Spain
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Barcelona , 08907, Spain
Barcelona , 08907, Spain
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Madrid , 28006, Spain
Madrid , 28006, Spain
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Madrid , 28046, Spain
Madrid , 28046, Spain
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Malaga , 29010, Spain
Malaga , 29010, Spain
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Oviedo , 33006, Spain
Oviedo , 33006, Spain
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Salamanca , 37007, Spain
Salamanca , 37007, Spain
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Valencia , 46009, Spain
Valencia , 46009, Spain
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Ankara , 06100, Turkey
Ankara , 06100, Turkey
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Kayseri , 38039, Turkey
Kayseri , 38039, Turkey
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