Myeloproliferative Neoplasms Clinical Trial

Clinical Trial Finder Myeloproliferative Neoplasms Trials

A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis)

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Summary

The purpose of this study is to assess the safety, tolerability, and efficacy of BMS-986158 alone and in combination with either Ruxolitinib or Fedratinib in participants with Dynamic International Prognostic Scoring System (DIPSS)-intermediate or high risk blood cancer. Part 1 consists of BMS-986158 in combination with either Ruxolitinib or Fedratinib and Part 2 consists of BMS-986158 in combination with either Ruxolitinib or Fedratinib and BMS-986158 alone.

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Eligibility Criteria

Inclusion Criteria:

Diagnosis of primary myelofibrosis (PMF), post-essential thrombocythemia (ET) or post-polycythemia vera (PV) myelofibrosis
Treatment-related toxicities from prior therapy resolved to Grade 1 or pre-treatment baseline or determined to be irreversible prior to study treatment
Must agree to follow specific methods of contraception, if applicable

Exclusion Criteria:

Women who are pregnant or breastfeeding at screening
Any significant acute or uncontrolled chronic medical illness

Other protocol-defined inclusion/exclusion criteria apply

Study is for people with:

Myeloproliferative Neoplasms

Phase:

Phase 1

Estimated Enrollment:

216

Study ID:

NCT04817007

Recruitment Status:

Recruiting

Sponsor:

Bristol-Myers Squibb

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There are 60 Locations for this study

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Moores Cancer Center-Clinical Trials Office - Hematology
La Jolla California, 92093, United States
Hoag Memorial Hospital Presbyterian
Newport Beach California, 92663, United States More Info
Pooja Motwani, Site 0069
Contact
501-425-4481
Florida Cancer Specialists Lake Mary Drug Development Unit
Lake Mary Florida, 32746, United States More Info
Alexander Philipovskiy, Site 0090
Contact
407-804-6133
Tulane University School of Medicine
New Orleans Louisiana, 70112, United States More Info
Hana Safah, Site 0043
Contact
504-988-6070
Tufts Medical Center
Boston Massachusetts, 02111, United States More Info
Zheng Zhou, Site 0082
Contact
617-636-7742
Massachusetts General Hospital
Boston Massachusetts, 02114, United States More Info
Gabriela Hobbs, Site 0093
Contact
617-724-3456
University of Massachusetts Medical School-Division of Hematology/Oncology
Worcester Massachusetts, 01655, United States More Info
Jonathan Gerber, Site 0038
Contact
508-635-7093
University Of Michigan
Ann Arbor Michigan, 48109, United States More Info
Moshe Talpaz, Site 0033
Contact
734-647-9913
John Theurer Cancer Center at Hackensack University Medical Center
Hackensack New Jersey, 07601, United States More Info
James McCloskey, Site 0045
Contact
551-996-3925
Levine Cancer Institute
Charlotte North Carolina, 28204, United States More Info
Aleksander Chojecki, Site 0078
Contact
980-442-4363
AHN West Penn Hospital
Pittsburgh Pennsylvania, 15224, United States More Info
Salman Fazal, Site 0042
Contact
412-578-4355
Lifespan Cancer Institute
Providence Rhode Island, 02906, United States More Info
John Reagan, Site 0071
Contact
401-444-5435
Medical University of South Carolina
Charleston South Carolina, 29425, United States More Info
Alexander Coltoff, Site 0087
Contact
631-487-7301
Mays Cancer Center
San Antonio Texas, 78229, United States
Local Institution - 0036
Blacktown New South Wales, 2148, Australia More Info
Site 0036
Contact
Local Institution - 0032
Wollongong New South Wales, 2500, Australia More Info
Site 0032
Contact
Local Institution - 0007
East Melbourne Victoria, 3002, Australia More Info
Site 0007
Contact
Local Institution - 0006
Heidelberg Victoria, 3084, Australia More Info
Site 0006
Contact
Local Institution - 0041
Nedlands Western Australia, 6009, Australia More Info
Site 0041
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Local Institution - 0015
West Perth Western Australia, 6005, Australia More Info
Site 0015
Contact
Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan-Institut de cancérologie et héma
Brest , 29200, France More Info
Jean-Christophe IANOTTO, Site 0030
Contact
+33298223786
Institut Paoli-Calmettes-Hematology
Marseille , 13273, France More Info
Jerome Rey, Site 0008
Contact
33491223481
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Hematology
Nice , 06202, France More Info
Michael Loschi, Site 0027
Contact
33492035841
Hôpital Saint-Louis-Centre d'Investigations Cliniques
Paris , 75010, France More Info
Jean-Jacques Kiladjian, Site 0011
Contact
0142499429
Gustave Roussy-DITEP
Villejuif , 94800, France More Info
Vincent Ribrag, Site 0010
Contact
33142114507
Local Institution - 0039
Essen Nordrhein-Westfalen, 45122, Germany More Info
Site 0039
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Local Institution - 0040
Chemnitz Sachsen, 09116, Germany More Info
Site 0040
Contact
Local Institution - 0050
Lübeck Schleswig-Holstein, 23538, Germany More Info
Site 0050
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Local Institution - 0068
Erding , 85435, Germany More Info
Site 0068
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Local Institution - 0035
Halle (Saale) , 06120, Germany More Info
Site 0035
Contact
Local Institution - 0061
Chaidari Attikí, 12462, Greece More Info
Site 0061
Contact
Local Institution - 0047
Thessaloniki Thessaloníki, 570 1, Greece More Info
Site 0047
Contact
Local Institution - 0086
Be'er Sheva HaDarom, 84101, Israel More Info
Site 0086
Contact
Local Institution - 0016
Jerusalem , 91120, Israel More Info
Site 0016
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Local Institution - 0018
Petah-Tikva , 49100, Israel More Info
Site 0018
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Local Institution - 0017
Ramat Gan , 52621, Israel More Info
Site 0017
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Local Institution - 0019
Tel Aviv , 64239, Israel More Info
Site 0019
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Local Institution - 0003
Bologna , 40138, Italy More Info
Site 0003
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Local Institution - 0002
Brescia , 25123, Italy More Info
Site 0002
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Local Institution - 0001
Firenze , 50134, Italy More Info
Site 0001
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Local Institution - 0012
Verona , 37134, Italy More Info
Site 0012
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Local Institution - 0049
Seongnam KyÇ’nggi-do, 13620, Korea, Republic of More Info
Site 0049
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Local Institution - 0048
Seoul Seoul-teukbyeolsi [Seoul], 05505, Korea, Republic of More Info
Site 0048
Contact
Local Institution - 0053
Seoul Seoul-teukbyeolsi [Seoul], 06591, Korea, Republic of More Info
Site 0053
Contact
Local Institution - 0063
Kraków Małopolskie, 31-50, Poland More Info
Site 0063
Contact
Local Institution - 0077
SÅ‚upsk Pomorskie, 76-20, Poland More Info
Site 0077
Contact
Local Institution - 0052
Bucuresti Cluj, 02232, Romania More Info
Site 0052
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Local Institution - 0083
București , 05009, Romania More Info
Site 0083
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Local Institution - 0051
Cluj , 40001, Romania More Info
Site 0051
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Local Institution - 0020
Badalona Barcelona [Barcelona], 08916, Spain More Info
Site 0020
Contact
Local Institution - 0054
Madrid Madrid, Comunidad De, 28034, Spain More Info
Site 0054
Contact
Local Institution - 0026
Madrid , 28041, Spain More Info
Site 0026
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Local Institution - 0021
Salamanca , 37007, Spain More Info
Site 0021
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Local Institution - 0029
Santander , 39008, Spain More Info
Site 0029
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Local Institution - 0094
València , 46026, Spain More Info
Site 0094
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Local Institution - 0088
Stanbul Ä°stanbul, 34214, Turkey More Info
Site 0088
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Local Institution - 0079
Ankara , 06100, Turkey More Info
Site 0079
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Local Institution - 0080
Ankara , 06200, Turkey More Info
Site 0080
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Local Institution - 0089
Ä°zmir , 35100, Turkey More Info
Site 0089
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Local Institution - 0081
Izmir , 35340, Turkey More Info
Site 0081
Contact
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How clear is this clinincal trial information?

Study is for people with:

Myeloproliferative Neoplasms

Phase:

Phase 1

Estimated Enrollment:

216

Study ID:

NCT04817007

Recruitment Status:

Recruiting

Sponsor:


Bristol-Myers Squibb

How clear is this clinincal trial information?

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