Myeloproliferative Neoplasms Clinical Trial
Extended Access of Momelotinib in Adults With Myelofibrosis
Summary
The primary objective of this study is to provide extended access and assess long-term safety of momelotinib (MMB) in participants with primary myelofibrosis (PMF) or post-polycythemia vera or post-essential thrombocythemia myelofibrosis (Post-PV/ET MF) enrolled in studies GS-US-352-0101 (NCT01969838), GS-US-352-1214 (NCT02101268), GS-US-352-1154 (NCT02124746), SRA-MMB-301 who are currently receiving treatment with MMB (available as 50mg,100 mg, 150 mg and 200 mg tablets) and have not experienced progression of disease. The secondary objective is to assess overall survival (OS) and leukemia free survival (LFS) in all subjects.
View Eligibility Criteria
Eligibility Criteria
Key Inclusion Criteria:
Currently enrolled in Studies GS-US-352-0101, GS-US-352-1214, GS-US-352-1154, or SRA-MMB-301
Able to comprehend and willing to sign the informed consent form
Key Exclusion Criteria:
Known hypersensitivity to MMB, its metabolites, or formulation excipients
NOTE: Other protocol defined Inclusion/ Exclusion criteria may apply.
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There are 112 Locations for this study
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IC Irvine Health
Orange California, 92868, United States
Orange California, 92868, United States
Stanford Hospital and Clinics
Stanford California, 94305, United States
Stanford California, 94305, United States
University of Colorado Cancer Center
Aurora Colorado, 80045, United States
Aurora Colorado, 80045, United States
Mayo Clinic Florida
Jacksonville Florida, 32224, United States
Jacksonville Florida, 32224, United States
Moffitt Cancer Center
Tampa Florida, 33612, United States
Tampa Florida, 33612, United States
Winship Cancer Institute, Emory University
Atlanta Georgia, 30322, United States
Atlanta Georgia, 30322, United States
Northwest Oncology & Hematology - Rolling Meadows
Rolling Meadows Illinois, 60008, United States
Rolling Meadows Illinois, 60008, United States
Saint Agnes Hospital
Baltimore Maryland, 21229, United States
Baltimore Maryland, 21229, United States
Dana-Farber Cancer Institute (DFCI)
Boston Massachusetts, 02215, United States
Boston Massachusetts, 02215, United States
Mayo Clinic - Department of Hematology
Rochester Minnesota, 55905, United States
Rochester Minnesota, 55905, United States
Washington University School of Medicine Siteman Cancer Center
Saint Louis Missouri, 63110, United States
Saint Louis Missouri, 63110, United States
Hackensack University Medical Center
Hackensack New Jersey, 07601, United States
Hackensack New Jersey, 07601, United States
Montefiore Medical Center
Bronx New York, 10467, United States
Bronx New York, 10467, United States
Cleveland Clinic Foundation
Cleveland Ohio, 44195, United States
Cleveland Ohio, 44195, United States
Mayo Clinic Building - Phoenix
Milwaukee Wisconsin, 53226, United States
Milwaukee Wisconsin, 53226, United States
Icon Cancer Care Wesley
Hyde Park Queensland, 4812, Australia
Hyde Park Queensland, 4812, Australia
Flinders Medical Centre
Adelaide South Australia, 5000, Australia
Adelaide South Australia, 5000, Australia
Frankston Hospital
Frankston Victoria, 3199, Australia
Frankston Victoria, 3199, Australia
The Alfred Hospital
Melbourne Victoria, 3004, Australia
Melbourne Victoria, 3004, Australia
Peter MacCallum Cancer Centre
Parkville Victoria, 3050, Australia
Parkville Victoria, 3050, Australia
Royal Perth Hospital
Perth Western Australia, 6160, Australia
Perth Western Australia, 6160, Australia
Ordensklinikum Linz Elisabethinen
Linz Upper Austria, 4020, Austria
Linz Upper Austria, 4020, Austria
Medizinische Universität Wien
Wien Vienna, 1090, Austria
Wien Vienna, 1090, Austria
Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan
Brugge West-Vlaanderen, 8000, Belgium
Brugge West-Vlaanderen, 8000, Belgium
Ziekenhuis Netwerk Antwerpen Stuivenberg
Antwerp , 2060, Belgium
Antwerp , 2060, Belgium
Universitaire Ziekenhuis Leuven
Leuven , 3000, Belgium
Leuven , 3000, Belgium
Centre Hospitalier Universitaire de Liège Site Sart Tilman
Liège , 4000, Belgium
Liège , 4000, Belgium
UMHAT Dr. Georgi Stranski EAD
Pleven , 5800, Bulgaria
Pleven , 5800, Bulgaria
Multiprofile Hospital for Active Treatment Ruse
Ruse , 7002, Bulgaria
Ruse , 7002, Bulgaria
National Specialized Hospital for Active Treatment of Haematologic Diseases
Sofia , 1431, Bulgaria
Sofia , 1431, Bulgaria
University Multiprofile Hospital for Active Treatment St. Ivan Rilski
Sofia , 1431, Bulgaria
Sofia , 1431, Bulgaria
Research Institute of the McGill University Health Centre
Montréal Quebec, H3H 2, Canada
Montréal Quebec, H3H 2, Canada
Sir Mortimer B. Davis Jewish General Hospital
Montréal , H3T 1, Canada
Montréal , H3T 1, Canada
Princess Margaret Cancer Centre
Toronto , M5G 2, Canada
Toronto , M5G 2, Canada
Aalborg University Hospital
Aalborg , 9000, Denmark
Aalborg , 9000, Denmark
Gentofte Hospital
Herlev , 2730, Denmark
Herlev , 2730, Denmark
Hopital Saint-Louis
Paris ILE-De-FRANCE, 75475, France
Paris ILE-De-FRANCE, 75475, France
Centre Hospitalier Le Mans
Le Mans Pays De La Loire, 72037, France
Le Mans Pays De La Loire, 72037, France
CHRU Huriez Lille
Lille Cedex , 59020, France
Lille Cedex , 59020, France
Institut Paoli Calmettes
Marseille , 13273, France
Marseille , 13273, France
Hôpital Haut-Lévêque
Pessac Cedex , 33604, France
Pessac Cedex , 33604, France
Centre Hospitalier Lyon Sud
Pierre Bénite Cedex , 69495, France
Pierre Bénite Cedex , 69495, France
Institut Universitaire du Cancer
Toulouse Cedex 9 , 31059, France
Toulouse Cedex 9 , 31059, France
Universitätsklinikum Aachen
Aachen Nordrhein-Westfalen, 52074, Germany
Aachen Nordrhein-Westfalen, 52074, Germany
Universitätsklinikum Halle
Halle Sachsen-Anhalt, 06120, Germany
Halle Sachsen-Anhalt, 06120, Germany
Universitätsklinikum Schleswig-Holstein - Campus Lübeck
Lübeck Schleswig-Holstein, 23538, Germany
Lübeck Schleswig-Holstein, 23538, Germany
University Hospital of Cologne
Cologne , 50937, Germany
Cologne , 50937, Germany
Universitätsklinikum Dresden
Dresden , 01307, Germany
Dresden , 01307, Germany
Universitätsklinikum Leipzig
Leipzig , 04103, Germany
Leipzig , 04103, Germany
Johannes Gutenberg-Universität Mainz
Mainz , 55131, Germany
Mainz , 55131, Germany
Petz Aladár Egyetemi Oktató Kórház - Győr
Győr Gyor-Moson-Sopron, 9023, Hungary
Győr Gyor-Moson-Sopron, 9023, Hungary
Szent Borbála Kórház
Tatabánya Komárom-Esztergom, 2800, Hungary
Tatabánya Komárom-Esztergom, 2800, Hungary
Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet
Budapest Pest, 1097, Hungary
Budapest Pest, 1097, Hungary
Szabolcs-Szatmár-Bereg Megyei Kórházak És Egyetemi Oktatókórház
Nyíregyháza Szabolcs-Szatmár-Bereg, 4400, Hungary
Nyíregyháza Szabolcs-Szatmár-Bereg, 4400, Hungary
Semmelweis Egyetem I. sz. Belgyogyaszati Klinika, Hematologia
Budapest , 1083, Hungary
Budapest , 1083, Hungary
Debreceni Egyetem Klinikai Kozpont, Belgyogyaszati Klinika, Haematologiai Tanszek
Debrecen , 4032, Hungary
Debrecen , 4032, Hungary
Somogy Megyei Kaposi Mor Oktató Kórház
Kaposvár , 7400, Hungary
Kaposvár , 7400, Hungary
Emek Medical Center
Afula , 18341, Israel
Afula , 18341, Israel
Barzilai Medical Center, Hematology Institute
Ashkelon , 78278, Israel
Ashkelon , 78278, Israel
Carmel Medical Center
Haifa , 34362, Israel
Haifa , 34362, Israel
Hadassh Medical Organization
Jerusalem , 91120, Israel
Jerusalem , 91120, Israel
Meir Medical Center
Kfar Saba , 44281, Israel
Kfar Saba , 44281, Israel
Azienda Ospedaliero - Universitaria Careggi
Firenze Florence, 50134, Italy
Firenze Florence, 50134, Italy
Azienda Socio Sanitaria Territoriale Monza - Ospedale San Gerardo
Monza Monza E Brianza, 20900, Italy
Monza Monza E Brianza, 20900, Italy
Azienda Ospedaliera Ospedali Riuniti Marche Nord
Pesaro Pesaro E Urbino, 61121, Italy
Pesaro Pesaro E Urbino, 61121, Italy
Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino
Torino Turin, 10126, Italy
Torino Turin, 10126, Italy
Azienda Ospedaliera Ordine Mauriziano di Torino
Torino Turin, 10128, Italy
Torino Turin, 10128, Italy
Azienda Ospedaliero Universitaria di Bologna Policlinico Sant'Orsola-Malpighi
Bologna , 40138, Italy
Bologna , 40138, Italy
Azienda Ospedaliera Universitaria San Martino
Genova , 16132, Italy
Genova , 16132, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milano , 20122, Italy
Milano , 20122, Italy
Azienda Ospedaliera Universitaria Federico II
Napoli , 80131, Italy
Napoli , 80131, Italy
IRCCS Centro di Riferimento Oncologico di Basilicata
Potenza , 85028, Italy
Potenza , 85028, Italy
Umberto I - Policlinico di Roma
Roma , 00161, Italy
Roma , 00161, Italy
Ospedale Policlinico Giambattista Rossi Borgo Roma
Verona , 37134, Italy
Verona , 37134, Italy
Inje University Haeundae Paik Hospital
Busan Busan Gwang'yeogsi [Pusan-Kwangyokshi], 48108, Korea, Republic of
Busan Busan Gwang'yeogsi [Pusan-Kwangyokshi], 48108, Korea, Republic of
Kyungpook National University Hospital
Daegu Daegu Gwang'yeogsi, 41944, Korea, Republic of
Daegu Daegu Gwang'yeogsi, 41944, Korea, Republic of
Severance Hospital
Seoul Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 03722, Korea, Republic of
Seoul Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 03722, Korea, Republic of
Samsung Medical Center
Seoul , 06351, Korea, Republic of
Seoul , 06351, Korea, Republic of
Catholic University of Korea Seoul Saint Mary's Hospital
Seoul , 06591, Korea, Republic of
Seoul , 06591, Korea, Republic of
Seoul National University Hospital
Seoul , 3080, Korea, Republic of
Seoul , 3080, Korea, Republic of
Maastricht University Medical Centre
Maastricht Limburg, 6229 , Netherlands
Maastricht Limburg, 6229 , Netherlands
Szpital Wojewódzki w Opolu
Opole Opolskie, 45-06, Poland
Opole Opolskie, 45-06, Poland
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza
Brzozów Podkarpacki, 36-20, Poland
Brzozów Podkarpacki, 36-20, Poland
Uniwersyteckie Centrum Kliniczne
Gdańsk Pomoskie, 80-95, Poland
Gdańsk Pomoskie, 80-95, Poland
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespól Szpitali Miejskich
Chorzów , 41-50, Poland
Chorzów , 41-50, Poland
Samodzielny Publiczny Szpital Kliniczny nr 1 w Lub
Lublin , 20-08, Poland
Lublin , 20-08, Poland
Szpital Uniwersytecki w Krakowie, Oddzial Kliniczny Hematologii
Małogoskie , 31-50, Poland
Małogoskie , 31-50, Poland
Samodzielny Publiczny Zaklad Opieki Zdrowotnej MSWiA w Poznaniu im. Ledwika Bierkowskiego
Poznań , 60-63, Poland
Poznań , 60-63, Poland
Policlinica de Diagnostic Rapid SA
Braşov , 50015, Romania
Braşov , 50015, Romania
Spitalul Clinic Coltea
Bucuresti , 03017, Romania
Bucuresti , 03017, Romania
Institutul Clinic Fundeni
Bucuresti , 22328, Romania
Bucuresti , 22328, Romania
Institutul Oncologic Prof. Dr. Ion Chiricuţă
Cluj-Napoca , 40012, Romania
Cluj-Napoca , 40012, Romania
Spitalul Clinic Municipal Filantropia Craiova
Craiova , 20014, Romania
Craiova , 20014, Romania
Institutul Regional De Oncologie IASI
Iasi , 70048, Romania
Iasi , 70048, Romania
Singapore General Hospital
Singapore , 16960, Singapore
Singapore , 16960, Singapore
Raffles Hospital
Singapore , 18877, Singapore
Singapore , 18877, Singapore
Hospital Germans Trias i Pujol
Badalona Barcelona, 08916, Spain
Badalona Barcelona, 08916, Spain
Institut Hospital del Mar d'Investigacions Mèdiques
Barcelona , 08003, Spain
Barcelona , 08003, Spain
Hospital Universitari Vall d'Hebron
Barcelona , 8035, Spain
Barcelona , 8035, Spain
Hospital Universitario Ramón y Cajal
Madrid , 28034, Spain
Madrid , 28034, Spain
Hospital Universitario 12 de Octubre
Madrid , 28041, Spain
Madrid , 28041, Spain
Hospital Universitario Puerta de Hierro Majadahonda
Madrid , 28222, Spain
Madrid , 28222, Spain
Clínica Universidad de Navarra
Pamplona , 31008, Spain
Pamplona , 31008, Spain
Hospital de Día Quirónsalud Zaragoza
Zaragoza , 50012, Spain
Zaragoza , 50012, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung , 807, Taiwan
Kaohsiung , 807, Taiwan
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung , 88301, Taiwan
Kaohsiung , 88301, Taiwan
National Taiwan University Hospital
Taipei , 100, Taiwan
Taipei , 100, Taiwan
Chang Gung Memorial Hospital - Linkou Branch
Taoyuan , 333, Taiwan
Taoyuan , 333, Taiwan
University Hospitals Bristol and Weston NHS Foundation Trust
Bristol England, BS2 8, United Kingdom
Bristol England, BS2 8, United Kingdom
NHS Lanarkshire
Airdrie Scotland, ML6 0, United Kingdom
Airdrie Scotland, ML6 0, United Kingdom
University Hospital of Wales
Cardiff , CF14 , United Kingdom
Cardiff , CF14 , United Kingdom
Imperial College Healthcare NHS Trust
London , W12 O, United Kingdom
London , W12 O, United Kingdom
Oxford University Hospitals NHS Trust
Oxford , OX3 7, United Kingdom
Oxford , OX3 7, United Kingdom
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