Myeloproliferative Neoplasms Clinical Trial

Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis

Summary

Myelofibrosis (MF) is a bone marrow illness that affects blood-forming tissues in the body. MF disturbs the body's normal production of blood cells, causing extensive scarring in the bone marrow. This leads to severe anemia, weakness, fatigue, and an enlarged spleen. The purpose of this study is to assess safety and change in spleen volume when navitoclax is given in combination with ruxolitinib, as compared to best available therapy, for adult participants with MF.

Navitoclax is an investigational drug (not yet approved) being developed for the treatment of MF. The study has 2 arms - A and B. In Arm A, participants will receive navitoclax in combination with ruxolitinib. In Arm B, participants will receive the best available therapy (BAT) for MF. Adult participants with a diagnosis of relapsed/refractory (R/R) MF will be enrolled. Approximately 330 participants will be enrolled in approximately 210 sites across the world.

In Arm A, participants will receive oral navitoclax tablet once daily with oral ruxolitinib tablet twice daily. In Arm B, participants will receive the BAT as identified by the investigator. Treatment will continue until clinical benefit is not seen, participants cannot tolerate the study drugs, or participants withdraw consent. The approximate treatment duration is about 3 years.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of treatment will be checked by medical assessments, blood and bone marrow tests, checking for side effects, and completing questionnaires.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Must complete the Myelofibrosis Symptom Assessment Form (MFSAF) v4.0 on at least 4 out of the 7 days immediately prior to the date of randomization and must agree to collect MFSAF data daily by ePRO device during the study collection window.

-- Has at least 2 symptoms each with an average score >= 3 or an average total score of >= 12, as measured by the MFSAF v4.0.

Documented diagnosis of primary myelofibrosis (MF) as defined by the World Health Organization (WHO) classification, post polycythemia vera (PPV)-MF, or post essential thrombocytopenia (PET)-MF, characterized by bone marrow fibrosis grades 2 or 3.
Classified as intermediate-2 or high-risk MF, as defined by the Dynamic International Prognostic Scoring System Plus (DIPSS+).

Must currently be on treatment or have received prior treatment with a single Janus Kinase 2 (JAK2) inhibitor, ruxolitinib, and meet one of the following criteria (in addition to the minimum splenomegaly and symptom burden also required for eligibility):

Treatment with ruxolitinib for >= 24 weeks that was stopped due to lack of spleen response (refractory), or loss of spleen response or symptom control after a previous response (relapsed), or was continued despite relapsed/refractory status.

Treatment with ruxolitinib for < 24 weeks with documented disease progression while on therapy as defined by any of the following:

Appearance of new splenomegaly that is palpable to at least 5 cm below the left costal margin (LCM) in participants with no evidence of splenomegaly prior to the initiation of ruxolitinib.
A >= 100% increase in the palpable distance below the LCM in participants with measurable spleen distance 5 to 10 centimeters (cm) prior to the initiation of ruxolitinib.
A >= 50% increase in the palpable distance below the LCM in participants with measurable spleen distance > 10 cm prior to the initiation of ruxolitinib.
A spleen volume increase of >= 25% (as assessed by Magnetic Resonance Imaging [MRI] or Computed Tomography [CT] scan) in participants with a spleen volume assessment prior to the initiation of ruxolitinib.
Prior treatment with ruxolitinib of at least 10 mg twice daily (BID) for >= 28 days with intolerance defined as new RBC transfusion requirement (at least 2 units/month for 2 months) while receiving a total daily ruxolitinib dose of >= 30 mg but unable to reduce dose further due to lack of efficacy.

Note: Participant must not require a ruxolitinib dose less than 10 mg BID (20 mg daily) due to prior history of ruxolitinibrelated ≥ Grade 3 toxicity.

Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2.
Splenomegaly defined as palpable spleen measurement >= 5 cm below left costal margin or spleen volume >= 450 cm3 as assessed centrally by MRI or CT scan.
Baseline platelet count >= 100 × 10^9/L.

Exclusion Criteria:

Received prior treatment with a BH3-mimetic compound, bromodomain and extra-terminal (BET) inhibitor, or prior use of > 1 JAK2 inhibitor or stem cell transplant.
Eligible for stem cell transplantation at the time of study entry.
Receiving medication that interferes with coagulation or platelet function within 3 days prior to the first dose of study drug or during the study treatment period except for low dose aspirin (up to 100 mg daily) and low molecular weight heparin (LMWH).
Receiving anticancer therapy for an active malignancy or MF including chemotherapy, radiation therapy, hormonal therapy such that at least 5 half-lives of that medication is completed at least 7 days prior to the first dose of study drug or within 30 days prior to first dose of study drug, whichever is shorter, and during the study treatment period (other than any overlapping therapy as part of the selected BAT).

Study is for people with:

Myeloproliferative Neoplasms

Phase:

Phase 3

Estimated Enrollment:

295

Study ID:

NCT04468984

Recruitment Status:

Active, not recruiting

Sponsor:

AbbVie

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There are 208 Locations for this study

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Ironwood Cancer & Res Ctr /ID# 222162
Chandler Arizona, 85224, United States
Highlands Oncology Group, PA /ID# 221826
Springdale Arkansas, 72762, United States
Moores Cancer Center at UC San Diego /ID# 219009
La Jolla California, 92093, United States
Long Beach Memorial Medical Ct /ID# 224542
Long Beach California, 90806, United States
Icri /Id# 221967
Whittier California, 90603, United States
St. Mary's Hospital Regional Cancer Center /ID# 224229
Grand Junction Colorado, 81501, United States
Augusta University Georgia Cancer Center /ID# 219051
Augusta Georgia, 30912, United States
Columbus Regional Research Institute /ID# 224410
Columbus Georgia, 31904, United States
Northwest Oncology & Hematology - Elk Grove Village /ID# 222818
Elk Grove Village Illinois, 60007, United States
Loyola University Medical Ctr /ID# 219048
Maywood Illinois, 60153, United States
Indiana Blood & Marrow Transpl /ID# 221587
Indianapolis Indiana, 46237, United States
Tulane Medical Center - New Orleans /ID# 222940
New Orleans Louisiana, 70112, United States
Ochsner Clinic Foundation-New Orleans /ID# 222777
New Orleans Louisiana, 70121, United States
American Oncology Partners of Maryland /ID# 222836
Bethesda Maryland, 20817, United States
Dana-Farber Cancer Institute /ID# 218998
Boston Massachusetts, 02215, United States
University of Michigan /ID# 218463
Ann Arbor Michigan, 48109, United States
Henry Ford Health System /ID# 221190
Detroit Michigan, 48202, United States
William Beaumont Hospital /ID# 222705
Royal Oak Michigan, 48073, United States
Saint Louis University Cancer Center /ID# 222287
Saint Louis Missouri, 63110, United States
Summit Medical Group-Florham Park /ID# 222620
Florham Park New Jersey, 07932, United States
Hackensack Univ Med Ctr /ID# 219047
Hackensack New Jersey, 07601, United States
The Cancer Institute at St. Francis Hospital /ID# 231782
Greenvale New York, 11548, United States
Manhattan Hematology Oncology MHO Associates /ID# 223193
New York New York, 10016, United States
Memorial Sloan Kettering Cancer Center-Koch Center /ID# 221081
New York New York, 10065, United States
Atrium Health Wake Forest Baptist Medical Center /ID# 222899
Winston-Salem North Carolina, 27157, United States
MetroHealth Medical Center /ID# 222650
Cleveland Ohio, 44109, United States
Hospital of the University of Pennsylvania /ID# 219001
Philadelphia Pennsylvania, 19104, United States
Fox Chase Cancer Center /ID# 223955
Philadelphia Pennsylvania, 19111, United States
Duplicate_Houston Methodist Hospital /ID# 223103
Houston Texas, 77030, United States
University of Texas Health San Antonio MD Anderson Cancer Center /ID# 233942
San Antonio Texas, 78229, United States
Utah Cancer Specialists Salt Lake Clinic /ID# 221962
Salt Lake City Utah, 84106, United States
Virginia Cancer Specialists - Fairfax /ID# 223016
Fairfax Virginia, 22031, United States
Providence Everett /ID# 223130
Everett Washington, 98201, United States
Yakima Valley Memorial Hosp /ID# 224368
Yakima Washington, 98902, United States
HSHS St. Vincent Hospital /ID# 224468
Green Bay Wisconsin, 54301, United States
The Kinghorn Cancer Centre /ID# 221097
Darlinghurst New South Wales, 2010, Australia
Border Medical Oncology Research Unit Albury Wodonga Regiona /ID# 223848
East Albury New South Wales, 2640, Australia
Calvary Mater Newcastle /ID# 224324
Waratah New South Wales, 2298, Australia
The Alfred Hospital /ID# 221096
Melbourne Victoria, 3004, Australia
Royal Perth Hospital /ID# 221099
Perth Western Australia, 6000, Australia
Universitaetsklinikum St. Poelten /ID# 221709
Sankt Poelten Niederoesterreich, 3100, Austria
Ordensklinikum Linz GmbH Elisabethinen /ID# 220914
Linz Oberoesterreich, 4010, Austria
Klinikum Wels-Grieskirchen GmbH /ID# 220915
Wels Oberoesterreich, 4600, Austria
Medizinische Universitaet Graz /ID# 220919
Graz Steiermark, 8010, Austria
Medizinische Universitaet Wien /ID# 220911
Vienna Wien, 1090, Austria
Hanusch Krankenhaus /ID# 220912
Wien , 1140, Austria
ZNA Cadix /ID# 221468
Antwerp Antwerpen, 2030, Belgium
Cliniques Universitaires UCL Saint-Luc /ID# 224221
Woluwe-Saint-Lambert Bruxelles-Capitale, 1200, Belgium
Grand Hopital de Charleroi /ID# 224827
Charleroi Hainaut, 6000, Belgium
UZ Gent /ID# 220841
Gent Oost-Vlaanderen, 9000, Belgium
AZ-Delta /ID# 221469
Roeselare West-Vlaanderen, 8800, Belgium
Vitaz /Id# 228150
Sint-Niklaas , 9100, Belgium
UMHAT Alexandrovska EAD /ID# 231652
Sofiya Sofia, 1431, Bulgaria
UMHAT Dr Georgi Stranski EAD /ID# 231650
Pleven , 5800, Bulgaria
Acibadem City Clinic Tokuda University Hospital EAD /ID# 231649
Sofia , 1407, Bulgaria
UMHAT Sveti Ivan Rilski /ID# 231651
Sofia , 1431, Bulgaria
UMHAT Sveta Marina /ID# 234119
Varna , 9010, Bulgaria
Juravinski Cancer Centre /ID# 220887
Hamilton Ontario, L8V 1, Canada
Ottawa Hospital Research Institute /ID# 238858
Ottawa Ontario, K1H 8, Canada
Princess Margaret Cancer Centre /ID# 253942
Toronto Ontario, M5G 2, Canada
CISSS-CA (Centre Integre de sante et de services sociaux de Chaudiere-Appalache) /ID# 222433
Levis Quebec, G6V 3, Canada
McGill University Health Center Research Institute /ID# 222614
Montreal Quebec, H4A 3, Canada
Clinical Hospital Dubrava /ID# 230801
Zagreb Grad Zagreb, 10000, Croatia
Klinicka bolnica Merkur /ID# 230799
Zagreb Grad Zagreb, 10000, Croatia
Klinicki bolnicki centar Zagreb /ID# 230798
Zagreb Grad Zagreb, 10000, Croatia
Klinicki Bolnicki Centar (KBC) Split /ID# 230800
Split Splitsko-dalmatinska Zupanija, 21000, Croatia
Klinicki bolnicki centar Osijek /ID# 231503
Osijek , 31000, Croatia
Fakultni nemocnice Brno /ID# 220959
Brno , 613 0, Czechia
Vseobecna fakultni nemocnice v Praze /ID# 220969
Praha , 128 0, Czechia
Aalborg University Hospital /ID# 224391
Aalborg Nordjylland, 9000, Denmark
Roskilde Sygehus /ID# 224456
Roskilde Sjælland, 4000, Denmark
Chu de Nice-Hopital Larchet Ii /Id# 256291
Nice Alpes-Maritimes, 06200, France
CHU NIMES - Hopital Caremeau /ID# 219128
Nimes CEDEX 9 Gard, 30029, France
Centre Hospitalier Universitaire de Bordeaux /ID# 222696
Pessac CEDEX Gironde, 33604, France
Hopital Avicenne - APHP /ID# 221287
Bobigny Ile-de-France, 93000, France
CHU de Nantes, Hotel Dieu -HME /ID# 219127
Nantes Pays-de-la-Loire, 44000, France
HCL - Hopital Lyon Sud /ID# 222695
Pierre Benite CEDEX Rhone, 69495, France
Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 223771
Chambery CEDEX Savoie, 73007, France
Chu Angers /Id# 219129
Angers , 49933, France
AP-HP - Hopital Saint-Louis /ID# 221390
Paris , 75010, France
Universitatsklinikum Mannheim /ID# 221529
Mannheim Baden-Wuerttemberg, 68167, Germany
Stauferklinikum Schwaebisch Gmuend /ID# 223948
Mutlangen Baden-Wuerttemberg, 73557, Germany
Gemeinschaftspraxis Dr. Heinrich und Prof. Bangerter /ID# 225025
Augsburg Bayern, 86150, Germany
BAG Freiberg-Richter, Jacobasch, Illmer, Wolf /ID# 221346
Dresden Sachsen, 01307, Germany
Augusta-Kranken-Anstalt gGmbH, Bochum-Mitte /ID# 224695
Bochum , 44791, Germany
Klinikum Chemnitz gGmbH /ID# 224575
Chemnitz , 09116, Germany
OncoResearch Lerchenfeld GmbH /ID# 225034
Hamburg , 22081, Germany
Klinikum rechts der Isar /ID# 221526
Munich , 81675, Germany
Universitaetsmedizin Rostock /ID# 224157
Rostock , 18057, Germany
Olympion General Clinic /ID# 261423
Patras Achaia, 25443, Greece
General Hospital of Athens Laiko /ID# 221175
Athens Attiki, 11527, Greece
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 221179
Athens , 10676, Greece
University General Hospital of Patras /ID# 221178
RION Patras Achaia , 26504, Greece
General Hospital of Thessaloniki George Papanikolaou /ID# 221463
Thessaloniki , 57010, Greece
Fejér Vármegyei Szent György Egyetemi Oktató Kórház /ID# 220949
Szekesfehervar Fejer, 8000, Hungary
Debreceni Egyetem-Klinikai Kozpont /ID# 220947
Debrecen Hajdu-Bihar, 4032, Hungary
Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 220948
Kaposvár Somogy, 7400, Hungary
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 220946
Nyiregyhaza Szabolcs-Szatmar-Bereg, 4400, Hungary
Szegedi Tudományegyetem /ID# 220955
Szeged , 6720, Hungary
HaEmek Medical Center /ID# 220839
Afula H_efa, 18341, Israel
Rambam Health Care Campus /ID# 219121
Haifa H_efa, 31096, Israel
The Lady Davis Carmel Medical Center /ID# 222973
Haifa H_efa, 34362, Israel
Assuta Ashdod Medical Center /ID# 225281
Ashdod HaDarom, 77476, Israel
Yitzhak Shamir Medical Center /ID# 222972
Zerifin HaMerkaz, 70300, Israel
Galilee Medical Center /ID# 225280
Nahariya HaTsafon, 22100, Israel
The Chaim Sheba Medical Center /ID# 219136
Ramat Gan Tel-Aviv, 52656, Israel
Tel Aviv Sourasky Medical Center /ID# 219135
Tel Aviv Tel-Aviv, 64239, Israel
Hadassah Medical Center-Hebrew University /ID# 219111
Jerusalem Yerushalayim, 91120, Israel
Hadassah Mt. Scopus /ID# 253394
Jerusalem Yerushalayim, 97654, Israel
Rabin Medical Center /ID# 219139
Haifa , 49414, Israel
Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 238438
Torette Ancona, 60020, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 219087
Rome Lazio, 00168, Italy
ASST Monza/Ospedale San Gerardo /ID# 225113
Monza Monza E Brianza, 20900, Italy
AOU Citta della Salute e della Scienza di Torino /ID# 221223
Torino Piemonte, 10126, Italy
Sapienza University /ID# 225731
Rome Roma, 00161, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni /ID# 221222
Bergamo , 24127, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 221077
Bologna , 40138, Italy
Presidio Ospedaliero Gaspare Rodolico /ID# 219089
Catania , 95123, Italy
Azienda Ospedaliero Universitaria Careggi /ID# 219090
Florence , 50134, Italy
Azienda Ospedaliera Universitaria Federico II /ID# 224673
Napoli , 80131, Italy
Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 221078
Palermo , 90127, Italy
Grande Ospedale Metropolitano Bianchi Melacrino Morelli /ID# 221220
Reggio Calabria , 89124, Italy
Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 221241
Udine , 33100, Italy
ASST Sette Laghi /ID# 234183
Varese , 21100, Italy
Azienda ULSS 8 Berica/Ospedale San Bortolo di Vicenza /ID# 221079
Vicenza , 36100, Italy
Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital /ID# 221150
Nagoya-shi Aichi, 453-8, Japan
Fujita Health University Hospital /ID# 221598
Toyoake Aichi, 470-1, Japan
Aomori Prefectural Central Hospital /ID# 221778
Aomori-shi Aomori, 030-8, Japan
Chiba University Hospital /ID# 224546
Chiba-shi Chiba, 260-8, Japan
National Cancer Center Hospital East /ID# 226653
Kashiwa-shi Chiba, 277-8, Japan
Ehime University Hospital /ID# 221158
Toon-shi Ehime, 791-0, Japan
Kyushu University Hospital /ID# 221606
Fukuoka-shi Fukuoka, 812-8, Japan
Fukushima Medical University Hospital /ID# 221877
Fukushima-shi Fukushima, 960-1, Japan
Gifu University Hospital /ID# 224371
Gifu-shi Gifu, 501-1, Japan
Sapporo Hokuyu Hospital /ID# 221149
Sapporo-shi Hokkaido, 003-0, Japan
Kobe City Medical Center General Hospital /ID# 221156
Kobe-shi Hyogo, 650-0, Japan
Kanazawa University Hospital /ID# 223028
Kanazawa-shi Ishikawa, 920-8, Japan
Iwate Medical University Hospital /ID# 222044
Shiwa-gun Iwate, 028-3, Japan
Shonan Kamakura General Hospital /ID# 223030
Kamakura-shi Kanagawa, 247-8, Japan
Kumamoto Shinto General Hospital /ID# 255645
Kumamoto-shi Kumamoto, 862-8, Japan
Kyoto University Hospital /ID# 223008
Kyoto-shi Kyoto, 606-8, Japan
Mie University Hospital /ID# 221665
Tsu-shi Mie, 514-8, Japan
University of Miyazaki Hospital /ID# 221821
Miyazaki-shi Miyazaki, 889-1, Japan
Niigata University Medical & Dental Hospital /ID# 223034
Niigata-shi Niigata, 951-8, Japan
Kurashiki Central Hospital /ID# 221690
Kurashiki-shi Okayama, 710-8, Japan
Kansai Medical University Hospital /ID# 257289
Hirakata-shi Osaka, 573-1, Japan
Osaka University Hospital /ID# 221159
Suita-shi Osaka, 565-0, Japan
Dokkyo Medical University Saitama Medical Center /ID# 222334
Koshigaya Saitama, 343-0, Japan
Juntendo University Shizuoka Hospital /ID# 221780
Izunokuni-shi Shizuoka, 410-2, Japan
Juntendo University Hospital /ID# 221154
Bunkyo-ku Tokyo, 113-8, Japan
Nippon Medical School Hospital /ID# 221676
Bunkyo-ku Tokyo, 113-8, Japan
Tokyo Medical University Hospital /ID# 221540
Shinjuku-ku Tokyo, 160-0, Japan
Tokyo Metropolitan Bokutoh Hospital /ID# 254774
Sumida-ku Tokyo, 130-8, Japan
University of Yamanashi Hospital /ID# 221706
Chuo-shi Yamanashi, 409-3, Japan
University of Tokyo - Research Hospital /ID# 257944
Tokyo , 108-8, Japan
Gachon University Gil Medical Center /ID# 220972
Incheon Gyeonggido, 21565, Korea, Republic of
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 219061
Seoul Seoul Teugbyeolsi, 06591, Korea, Republic of
Pusan National University Hospital /ID# 220980
Busan , 49241, Korea, Republic of
Seoul National University Hospital /ID# 219060
Seoul , 03080, Korea, Republic of
Samsung Medical Center /ID# 221091
Seoul , 06351, Korea, Republic of
Aotearoa Clinical Trials /ID# 232201
Papatoetoe Auckland, 2025, New Zealand
Wojewódzki Szpital Specjalistyczny im. M.Kopernika w Łodzi /ID# 221161
Lodz Lodzkie, 93-50, Poland
Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie /ID# 221124
Lublin Lubelskie, 20-08, Poland
SP ZOZ Szpital Uniwersytecki w Krakowie /ID# 221160
Krakow Malopolskie, 31-50, Poland
Lux Med Onkologia - Szpital Szamocka /Id# 221265
Warszawa Mazowieckie, 01-74, Poland
MTZ Clinical Research Powered by Pratia /ID# 221759
Warszawa Mazowieckie, 02-17, Poland
Uniwersyteckie Centrum Kliniczne /ID# 221298
Gdansk Pomorskie, 80-21, Poland
ARS-MEDICAL Sp. z o.o. /ID# 238336
Pila Wielkopolskie, 64-92, Poland
Szpital Kliniczny im. Heliodora Swiecickiego Uniwersytetu Medycznego im. Karola /ID# 241031
Poznan Wielkopolskie, 60-56, Poland
Pratia Onkologia Katowice /ID# 224526
Katowice , 40-51, Poland
Hospital del Centro Comprensivo de Cancer de la UPR /ID# 223281
San Juan , 00927, Puerto Rico
Moscow State budget healthcare /ID# 221116
Moscow Moskva, 12528, Russian Federation
Hospital n.a. V.V. Veresaev /ID# 225221
Moscow , 12764, Russian Federation
Russian Research Institute of Hematology and Transfusiology of the FMBA /ID# 221115
Sankt-Peterburg , 19102, Russian Federation
Almazov National Medical Research Centre /ID# 221114
Sankt-Peterburg , 19734, Russian Federation
Tula Regional Clinical Hospital /ID# 221302
Tula , 30005, Russian Federation
University Clinical Center Serbia /ID# 231058
Belgrade Beograd, 11000, Serbia
Clin Hosp Ctr Bezanijska Kosa /ID# 231059
Belgrade Beograd, 11080, Serbia
Clinical Center Vojvodina /ID# 231057
Novi Sad , 21000, Serbia
Duplicate_Wits Clinical Research Site /ID# 231554
Johannesburg Gauteng, 2193, South Africa
Alberts Cellular Therapy /ID# 231556
Pretoria Gauteng, 0044, South Africa
Complejo Hospitalario Universitario A Coruña /ID# 224617
A Coruña A Coruna, 15006, Spain
Hospital Clínico Universitario de Santiago-CHUS /ID# 221616
Santiago de Compostela A Coruna, 15706, Spain
Hospital Universitario Central de Asturias /ID# 224815
Oviedo Asturias, 33011, Spain
Hospital Universitario Germans Trias i Pujol /ID# 233727
Badalona Barcelona, 08916, Spain
Hospital Universitario Dr. Negrin /ID# 220923
Las Palmas de Gran Canaria Las Palmas, 35019, Spain
Hospital Parc de Salut del Mar /ID# 220922
Barcelona , 08003, Spain
Hospital Universitario Vall d'Hebron /ID# 240979
Barcelona , 08035, Spain
Hospital Universitario Virgen de las Nieves /ID# 253936
Granada , 18014, Spain
Hospital Universitario 12 de Octubre /ID# 233726
Madrid , 28041, Spain
Hospital Universitario La Paz /ID# 224813
Madrid , 28046, Spain
Hospital Regional Universitario de Malaga /ID# 221906
Malaga , 29011, Spain
Hospital Universitario de Salamanca /ID# 221904
Salamanca , 37711, Spain
Hospital Universitario Virgen del Rocio /ID# 221932
Sevilla , 41013, Spain
Hospital Clinico Universitario de Valencia /ID# 220920
Valencia , 46010, Spain
Skane University Hospital Lund /ID# 220834
Lund Skane Lan, 224 8, Sweden
Duplicate_Universitätsspital Basel /ID# 221261
Basel Basel-Stadt, 4031, Switzerland
Inselspital, Universitaetsspital Bern /ID# 223439
Bern , 3010, Switzerland
Kaohsiung Chang Gung Memorial Hospital /ID# 218985
Kaohsiung City Kaohsiung, 833, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 218980
Kaohsiung , 807, Taiwan
China Medical University Hospital /ID# 218979
Taichung , 40447, Taiwan
Chi Mei Hospital - Liouying /ID# 221144
Tainan City , 73657, Taiwan
Taipei Veterans General Hosp /ID# 221147
Taipei , 11217, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 218982
Taoyuan City , 333, Taiwan
Gulhane Askeri Tip Academy /ID# 224568
Ankara , 06010, Turkey
Trakya University Medical Facu /ID# 224572
Edirne, Istanbul , 22030, Turkey
Ege University Medical Faculty /ID# 224570
Izmir , 35040, Turkey
Mersin University Medical /ID# 224571
Mersin , 33343, Turkey
Ondokuz mayis University Facul /ID# 224567
Samsun , 55200, Turkey
United Lincolnshire Hospitals NHS Trust /ID# 224613
Lincoln Lincolnshire, LN2 4, United Kingdom
Guys and St Thomas NHS Foundation Trust /ID# 221041
London London, City Of, SE1 9, United Kingdom
James Paget University Hospitals NHS Foundation Trust /ID# 221219
Great Yarmouth Norfolk, NR31 , United Kingdom
University Hospitals Birmingham NHS Foundation Trust /ID# 221334
Birmingham , B15 2, United Kingdom
NHS Lothian /ID# 224378
Edinburgh , EH3 9, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 221335
Newcastle upon Tyne , NE3 3, United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Myeloproliferative Neoplasms

Phase:

Phase 3

Estimated Enrollment:

295

Study ID:

NCT04468984

Recruitment Status:

Active, not recruiting

Sponsor:


AbbVie

How clear is this clinincal trial information?

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