Non Hodgkin Lymphoma Clinical Trial
A Randomized Phase IIb Placebo-Controlled Study of R-ICE Chemotherapy With and Without SGN-40 for Patients With DLBCL
Summary
This is a randomized trial to estimate the activity of R-ICE plus SGN-40 vs. R-ICE plus placebo in patients with DLBCL. The study will assess safety and tolerability and will measure any additional clinical benefit observed in patients receiving SGN-40.
Eligibility Criteria
Inclusion Criteria:
Confirmed diagnosis of de novo or transformed DLBCL, or follicular grade 3b lymphoma.
Received at least four cycles of first-line therapy with R-CHOP, or equivalent.
Best clinical response to first-line therapy of stable disease, partial response, or complete response.
At least one measureable lesion that is both greater than or equal to 1.5cm by radiographic imaging and by positive FDG-PET scan.
Exclusion Criteria:
Leptomeningeal or central nervous system lymphoma.
Received any therapy for relapsed or progressive disease except for local radiation, steroids, or rituximab.
Received a hematopoietic stem cell transplant.
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There are 64 Locations for this study
Birmingham Alabama, 35294, United States
Los Angeles California, 90095, United States
Stanford California, 94305, United States
Newark Delaware, 19718, United States
Washington District of Columbia, 20007, United States
Orlando Florida, 32806, United States
Atlanta Georgia, 30322, United States
Chicago Illinois, 60611, United States
Louisville Kentucky, 40202, United States
Lansing Michigan, 48912, United States
Rochester Minnesota, 55905, United States
St. Louis Park Minnesota, 55416, United States
St. Louis Missouri, 63110, United States
Farmington New Mexico, 87401, United States
New York New York, 10019, United States
Cleveland Ohio, 44195, United States
Columbus Ohio, 43210, United States
Portland Oregon, 97213, United States
Charleston South Carolina, 29425, United States
Nashville Tennessee, 37203, United States
Dallas Texas, 75246, United States
Houston Texas, 77030, United States
Tacoma Washington, 98405, United States
Morgantown West Virginia, 26506, United States
Darlinghurst New South Wales, 2010, Australia
Gosford New South Wales, 2250, Australia
St. Leonards New South Wales, 2065, Australia
Herston Queensland, 4029, Australia
Fitzroy Victoria, 3065, Australia
Perth Western Australia, 6000, Australia
Gent , 9000, Belgium
Wilrijk , 2610, Belgium
Yvoir , 5530, Belgium
Hradec Kralove , 500 0, Czech Republic
Praha 2 , 128 0, Czech Republic
Praha 5 , 150 0, Czech Republic
Le Chesnay , 78157, France
Lyon , 69373, France
Nantes , 44093, France
Paris , 75743, France
Pessac , 33604, France
Pierre Benite , 69485, France
Rouen , 76038, France
Toulouse , 31059, France
Villejuif , 94805, France
Mainz , 55101, Germany
Monchengladbach , 41063, Germany
Ulm , 89081, Germany
Debrecen , H-401, Hungary
Gyor , H-902, Hungary
Kaposvar , , Hungary
Szeged , H-672, Hungary
Florence , 50139, Italy
Genova , 16132, Italy
Siena , 53100, Italy
Gdansk , 80-95, Poland
Krakow , 31-50, Poland
Lodz , 93-51, Poland
Warszawa , 02-76, Poland
Warszawa , 02-78, Poland
Wroclaw , 50-36, Poland
Barcelona , 08036, Spain
Barcelona , 08041, Spain
Barcelona , , Spain
Madrid , 28034, Spain
Valencia , 46009, Spain
How clear is this clinincal trial information?
Please confirm you are a US based health care provider:
Yes, I am a health care Provider No, I am not a health care providerSign Up Now.
Take Control of Your Disease Journey.
Sign up now for expert patient guides, personalized treatment options, and cutting-edge insights that can help you push for the best care plan.