Non Hodgkin Lymphoma Clinical Trial
A Study for Patients With Non-Hodgkin’s Lymphomas
Summary
In this study, all patients will get investigational drug. There will be no comparator drug. This study will evaluate three tumor types: T-cell lymphoma, Indolent B-cell lymphoma, and Aggressive B-cell lymphoma. Each tumor type will include several tumor subtypes:
T-cell lymphoma: Peripheral and Cutaneous T-cell lymphoma (PTCL, CTCL)
Indolent B-cell lymphoma: Small lymphocytic lymphoma, follicular lymphoma (Gr 1 or 2) and marginal zone lymphoma
Aggressive B-cell lymphoma: Primary CNS lymphoma, follicular lymphoma (Gr 3a and 3b) and aggressive lymphoma with prior clinical history of indolent lymphoma.
Eligibility Criteria
Inclusion Criteria:
Have measurable lesions
Have recovered from prior chemotherapies
Have an estimated life expectancy of at least 12 weeks
Hepatic: total bilirubin less than or equal to 1.5 XULN; ATL/AST less than or equal to 2.0 x ULN (less than 5x if liver metastases are present)
Renal: serum creatinine less than or equal to 1.5XULN
Adequate bone marrow reserve: platelets greater than or equal to 75 x 109 /Liter (L) Criteria:
Have a second primary malignancy (except adequately treated nonmelanomatous skin cancer, or other cancer that is considered cured by surgical resection or radiation).
Anti-lymphoma therapy within the past 3 weeks
Unable to swallow tablets
Unable to discontinue use of carbamazepine, phenobarbital and phenytoin at least 14 days prior to study enrollment
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There are 14 Locations for this study
Anaheim California, 92801, United States
Garran Australian Capital Territory, 2605, Australia
Gosford New South Wales, 2250, Australia
Auchenflower Queensland, 4066, Australia
Prahran Victoria, 3181, Australia
Brasilia , 70710, Brazil
Curitiba , 81520, Brazil
Jau , 17210, Brazil
Porto Alegre , 90430, Brazil
São Paulo , 01323, Brazil
Monterrey , 64460, Mexico
Tepic , 63000, Mexico
Tlalpan , 14080, Mexico
Lima , LIMA1, Peru
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