Non Hodgkin Lymphoma Clinical Trial

A Study of Azidothymidine (AZT) in the Treatment of HIV Infection in Patients Receiving a Bone Marrow Transplant

Summary

To determine whether zidovudine (AZT) in conjunction with bone marrow transplantation prevents the reinfection of donor hematopoietic/lymphoid cells in patients with positive HTLV III antibody and large cell/diffuse histiocytic lymphoma. Patients who are candidates will be evaluated for HTLV III activity and drug levels.

View Eligibility Criteria

Eligibility Criteria

Exclusion Criteria

Co-existing Condition:

Patients with current life-threatening infection at time of transplant that would preclude a transplant are excluded.

Concurrent Medication:

Excluded:

Other anti-retroviral agents.

Patients with current life-threatening infection at time of transplant that would preclude a transplant are excluded.

Patients must be:

HTLV III antibody positive by ELISA or Western blot or HTLV III viremia.
At high mortal risk with a diagnosis of AIDS or AIDS Related Complex (ARC).
Also patient must fall into one of the following categories:
Have an HIV seronegative identical twin to serve as a bone marrow donor.
Have documentation of large cell/diffuse histiocytic lymphoma/DPDL.
Be a good risk candidate for bone marrow transplant.

Study is for people with:

Non Hodgkin Lymphoma

Study ID:

NCT00002284

Recruitment Status:

Completed

Sponsor:

Glaxo Wellcome

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There is 1 Location for this study

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Johns Hopkins Hemapheresis Treatment Ctr
Baltimore Maryland, 21205, United States

How clear is this clinincal trial information?

Study is for people with:

Non Hodgkin Lymphoma

Study ID:

NCT00002284

Recruitment Status:

Completed

Sponsor:


Glaxo Wellcome

How clear is this clinincal trial information?

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