A Study of Rituximab and Bevacizumab in Patients With Follicular Non-Hodgkin’s Lymphoma

Inclusion Criteria:

To be included in the study, you must meet the following criteria:

Follicular NHL, grades 1 or 2 confirmed by a biopsy sample
18 years of age or older
Evidence of disease progression at time of study entry
Must have had at least one previous chemotherapy regimen and not more than two previous chemotherapy regimens.
Patients who have received previous rituximab are eligible as long as progression occurred more than six months following completion of previous rituximab therapy.
Measurable or evaluable disease
Able to perform activities of daily living without considerable assistance
Adequate bone marrow, kidney, and liver function
Signed informed consent obtained prior to initiation of any study-specific procedures or treatment.

Exclusion Criteria:

You cannot participate in the study if any of the following apply to you:

Treatment with more than two previous chemotherapy regimens
Prior treatment with bevacizumab or other similar agents
Progressive NHL less than 6 months after receiving previous rituximab
More than 1 prior treatment with investigational agents within 4 weeks prior to entering this study
Spread of NHL to brain or nervous system
History of any other uncontrolled or significant disease or medical condition that may put them at high risk for treatment complications with these agents

Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have. You can then decide if you wish to participate.