Non Hodgkin Lymphoma Clinical Trial

A Study to Evaluate the Safety, Tolerability, and Efficacy of Relatlimab in Relapsed or Refractory B-Cell Malignancies

Summary

The primary objective of this study is to characterize the safety, tolerability, dose-limiting toxicities (DLTs), and maximum tolerated dose (MTD) of relatlimab administered alone or in combination with nivolumab to subjects with relapsed or refractory B-cell malignancies. Co-primary objective is to investigate the preliminary efficacy of relatlimab in combination with nivolumab in subjects with relapsed or refractory Hodgkin lymphoma (HL), and relapsed or refractory Diffused Large B Cell lymphoma (DLBCL)

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Must have histologic or cytologic confirmation of chronic lymphocytic leukemia, Hodgkin lymphoma, Non-Hodgkin lymphoma, or Multiple Myeloma and have relapsed following prior treatment or been refractory to prior treatment
Must have progressed or been refractory to, at least one prior standard therapy, including radiation, immunomodulatory agents (eg, lenalidomide), immunotherapy, cytotoxic chemotherapy, and select antibody (anti-CD20, alemtuzumab, or anti-CD30) therapy.
Must be more than 100 days post autologous transplant

Exclusion Criteria:

Known or suspected central nervous system (CNS) metastases or with the CNS as the only site of active disease (controlled CNS metastases are allowed)
Known or suspected autoimmune disease
History of allergy to anti-PD-1 or anti-PD-L1 antibody therapy or to other monoclonal antibodies or related compounds or to any of their components

Other protocol-defined inclusion/exclusion criteria apply

Study is for people with:

Non Hodgkin Lymphoma

Phase:

Phase 1

Estimated Enrollment:

106

Study ID:

NCT02061761

Recruitment Status:

Completed

Sponsor:

Bristol-Myers Squibb

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There are 10 Locations for this study

See Locations Near You

Local Institution - 0007
Baltimore Maryland, 21205, United States
Local Institution - 0004
Boston Massachusetts, 02215, United States
Barbara Ann Karmanos Cancer Institute
Detroit Michigan, 48201, United States
Local Institution - 0010
Saint Louis Missouri, 63110, United States
Weill Cornell Medical College
New York New York, 10021, United States
Local Institution - 0002
Portland Oregon, 97239, United States
Local Institution - 0006
Houston Texas, 77030, United States
Local Institution - 0001
Seattle Washington, 98109, United States
Local Institution - 0011
Vancouver British Columbia, V5Z 4, Canada
Local Institution - 0012
Toronto Ontario, M5G 2, Canada

How clear is this clinincal trial information?

Study is for people with:

Non Hodgkin Lymphoma

Phase:

Phase 1

Estimated Enrollment:

106

Study ID:

NCT02061761

Recruitment Status:

Completed

Sponsor:


Bristol-Myers Squibb

How clear is this clinincal trial information?

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