Non Hodgkin Lymphoma Clinical Trial
A Study to Evaluate the Safety, Tolerability, and Efficacy of Relatlimab in Relapsed or Refractory B-Cell Malignancies
Summary
The primary objective of this study is to characterize the safety, tolerability, dose-limiting toxicities (DLTs), and maximum tolerated dose (MTD) of relatlimab administered alone or in combination with nivolumab to subjects with relapsed or refractory B-cell malignancies. Co-primary objective is to investigate the preliminary efficacy of relatlimab in combination with nivolumab in subjects with relapsed or refractory Hodgkin lymphoma (HL), and relapsed or refractory Diffused Large B Cell lymphoma (DLBCL)
Eligibility Criteria
Inclusion Criteria:
Must have histologic or cytologic confirmation of chronic lymphocytic leukemia, Hodgkin lymphoma, Non-Hodgkin lymphoma, or Multiple Myeloma and have relapsed following prior treatment or been refractory to prior treatment
Must have progressed or been refractory to, at least one prior standard therapy, including radiation, immunomodulatory agents (eg, lenalidomide), immunotherapy, cytotoxic chemotherapy, and select antibody (anti-CD20, alemtuzumab, or anti-CD30) therapy.
Must be more than 100 days post autologous transplant
Exclusion Criteria:
Known or suspected central nervous system (CNS) metastases or with the CNS as the only site of active disease (controlled CNS metastases are allowed)
Known or suspected autoimmune disease
History of allergy to anti-PD-1 or anti-PD-L1 antibody therapy or to other monoclonal antibodies or related compounds or to any of their components
Other protocol-defined inclusion/exclusion criteria apply
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There are 10 Locations for this study
Baltimore Maryland, 21205, United States
Boston Massachusetts, 02215, United States
Detroit Michigan, 48201, United States
Saint Louis Missouri, 63110, United States
New York New York, 10021, United States
Portland Oregon, 97239, United States
Houston Texas, 77030, United States
Seattle Washington, 98109, United States
Vancouver British Columbia, V5Z 4, Canada
Toronto Ontario, M5G 2, Canada
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