Non Hodgkin Lymphoma Clinical Trial
An Investigational Immuno-therapy Safety and Effectiveness Study of Nivolumab in Combination With Brentuximab Vedotin to Treat Non-Hodgkin Lymphomas
Summary
The purpose of this study is to determine whether Nivolumab, in combination with brentuximab vedotin, is safe and effective in patients with certain subtypes of non-Hodgkin's lymphomas with CD30 expression that have not responded to treatment or have come back. The subtypes we are studying are Diffuse Large B-Cell Lymphoma (DLBCL), Peripheral T-Cell Lymphoma (PTCL), Cutaneous T-Cell Lymphoma (CTCL), Primary Mediastinal Large B-Cell Lymphoma (PMBL) and Mediastinal Gray Zone Lymphoma (MGZL).
Eligibility Criteria
For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com
Inclusion Criteria:
Relapsed/refractory diffuse large B cell lymphoma (DLBCL), relapsed/refractory peripheral T cell lymphoma (PTCL) (all subtypes excluding anaplastic large cell lymphoma), relapsed/refractory Cutaneous T cell lymphoma (CTCL) mycosis fungoides/sezary syndrome (MF/SS), relapsed/refractory primary mediastinal B lymphoma (PMBL), and relapsed/refractory mediastinal gray zone lymphoma (MGZL)
Expression of CD30
Subjects must be 18 years or older (≥ 15 years for PMBL)
Exclusion Criteria:
Known central nervous system (CNS) lymphomas; Active cerebral/meningeal disease related to the underlying malignancy
Active, known, or suspected autoimmune disease
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There are 27 Locations for this study
Birmingham Alabama, 35294, United States
Miami Florida, 33136, United States
Tampa Florida, 33612, United States
Atlanta Georgia, 30322, United States
Chicago Illinois, 60637, United States
Rochester Minnesota, 55905, United States
Saint Louis Missouri, 63110, United States
New York New York, 10021, United States
New York New York, 10029, United States
Rochester New York, 14642, United States
Charlotte North Carolina, 28204, United States
Columbus Ohio, 43210, United States
Oklahoma City Oklahoma, 73104, United States
Portland Oregon, 97213, United States
Greenville South Carolina, 29607, United States
Seattle Washington, 98109, United States
Vancouver British Columbia, V5Z 4, Canada
Toronto Ontario, M5G 2, Canada
Montreal Quebec, H3T 1, Canada
Paris , 75010, France
Pierre Benite Cedex , 69495, France
Bergamo , 0, Italy
Bologna , 40126, Italy
Rozzano (milano) , 20089, Italy
Hospitalet de Llobregat - Barcelona , 08908, Spain
Oxford Oxfordshire, OX3 7, United Kingdom
Sutton Surrey, SM2 5, United Kingdom
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