Avastin (Bevacizumab) Plus Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) for Advanced Stage Hodgkin Lymphoma

Inclusion Criteria:

18 years of age or older
Biopsy proven classical Hodgkin lymphoma. Classical Hodgkin lymphoma includes the subtypes of nodular sclerosis, mixed cellularity, lymphocyte rich, lymphocyte depleted, and classical Hodgkin lymphoma unspecified
Advanced stage (Stage III or IV) disease
Measurable disease on cross sectional imaging
ECOG Performance Status 0-2
Adequate blood counts and organ function

Exclusion Criteria:

Pregnant or lactating women
Laboratory Parameters as outlined in the protocol
LV ejection fraction lower than normal as assessed by echocardiogram or MUGA scan
DLCO less than 60% as measured by pulmonary function tests
Prior history of another malignancy (except for non-melanoma skin cancer or in situ cervical or breast cancer) unless disease free for over one year
Current or recent (within 4 weeks of the first infusion of this study) participation in an experimental drug study
Life expectancy of less than 12 weeks
Inability to comply with study procedures
Inability to give informed consent
Inadequately controlled hypertension
Any prior history of hypertensive crisis or hypertensive encephalopathy
NYHA Grade II or greater congestive heart failure
History of myocardial infarction or unstable angina within 6 months prior to study enrollment
History of stroke or transient ischemic attack within 6 months prior to study enrollment
Known CNS involvement of Hodgkin lymphoma
Significant vascular disease
Symptomatic peripheral vascular disease
Evidence of bleeding diatheses or coagulopathy
Use of daily anticoagulant medications including warfarin, heparins, or aspirin >325mg daily
Major surgical procedure or significant traumatic injury within 28 days prior to study enrollment or anticipation of need for major surgical procedure during the course of the study
Core biopsy or other minor surgical procedure, excluding placement of a vascular access device, within 7 days of study enrollment
History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to study enrollment
Serious, non-healing wound, ulcer, or bone fracture
Proteinuria at screening
Known hypersensitivity to any component of bevacizumab
Pregnant or lactating