Non Hodgkin Lymphoma Clinical Trial
Cardiac Magnetic Resonance Imaging in Patients With Non-Hodgkin Lymphoma or Hodgkin Lymphoma Receiving Doxorubicin
RATIONALE: Diagnostic procedures, such as cardiac magnetic resonance imaging, may help doctors detect early changes in the heart caused by chemotherapy.
PURPOSE: This clinical trial is studying how well cardiac magnetic resonance imaging works in patients with newly diagnosed non-Hodgkin lymphoma or Hodgkin lymphoma receiving doxorubicin.
To determine whether early myocardial structural and functional changes can be detected using cardiac MRI in patients with newly diagnosed non-Hodgkin lymphoma or Hodgkin lymphoma receiving doxorubicin hydrochloride-based chemotherapy.
OUTLINE: Patients undergo cardiac MRI with gadolinium contrast prior to initiation of doxorubicin hydrochloride-based chemotherapy and 3 months after completion of six courses of chemotherapy for non-Hodgkin lymphoma and twelve courses of chemotherapy for Hodgkin lymphoma.
Diagnosis of non-Hodgkin lymphoma or Hodgkin lymphoma
o Newly diagnosed disease
Planning to receive doxorubicin hydrochloride-based chemotherapy solely at the University of Nebraska Medical Center
Fertile patients must use effective contraception
Able to lie flat for 90 minutes
Able to fulfill the requirements of the study
Not pregnant or nursing
No chronic kidney disease stages 3-5 (glomerular filtration rate < 60 mL/min)
No metallic foreign body not approved for MRI
No known hypersensitivity to gadolinium contrast or other required drugs in the study
No comorbidity or condition which, in the opinion of the investigator, may interfere with the assessments and procedures of this study
No prior chemotherapy
No prior radiotherapy to mantle or mediastinum
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There is 1 Location for this study
Omaha Nebraska, 68198, United States
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